AstraZeneca PLC ($AZN)

Good morning to those joining from the U.K. and the U.S. Good afternoon to those in Central Europe, and good evening to those listening in Asia. Welcome to AstraZeneca's Q1 2026 webinar for investors and analysts. Before I hand over to AstraZeneca, I'd like to read the safe harbor statement. The company intends to utilize the safe harbor provisions of the United States Private Securities Litigation Reform Act of 1995. Participants on this call may make forward-looking statements with respect to the operations and financial performance of AstraZeneca. Although we believe our expectations are based on reasonable assumptions, by their very nature, forward-looking statements involve risks and uncertainties and may be influenced by factors that could cause actual results to differ materially from those expressed or implied by these forward-looking statements. Any forward-looking statements made on this call reflect the knowledge and information available at the time of this call. The company undertakes no obligation to update forward-looking statements. Please carefully review the forward-looking statements disclaimer in the slide deck that accompanies this presentation and webcast. [Operator Instructions] And with that, I'll now hand you over to the company.

A warm welcome to AstraZeneca's First Quarter 2026 Presentation Conference Call and webcast for investors and analysts. I'm Joris Silon, Head of Investor Relations. And before I hand over to Pascal and the members of our executive team, I would like to cover some housekeeping items. All of the materials presented today are available on our AstraZeneca Investor Relations website. Next slide. This slide contains our forward-looking statements, including the safe harbor provisions, which I would encourage you to take the time to read. We will be making comments on our performance using constant exchange rates, or CER, core financial numbers and other non-GAAP measures. A non-GAAP to GAAP call reconciliation is contained within the results announcement. All numbers quoted are in millions of U.S. dollars unless stated otherwise. Next slide, please. This slide shows our agenda for today's call. Following our prepared remarks, we will open the line for questions. As usual, we will try to address as many questions as we can during the allocated time. Although please limit the number of questions you ask to allow others a fair chance to participate in the Q&A. And with that, please advance to the next slide. And Pascal, over to you.

Thank you, Joris, and welcome, everyone. Next slide, please. We delivered a strong first quarter, building on the momentum we generated in 2025. Total revenue grew 8% in the quarter, supported by a robust demand for our innovative medicines. We saw strong growth in operating profit, which increased 12%, reflecting our ongoing focus on operating leverage. Core EPS grew 5%, our EPS growth was held back by the low tax rate in the prior period. Since our Q4 2025 results, we have secured 14 approvals in major regions across our diverse portfolio a clear illustration of the value our medicines bring to patients globally. Additionally, we continue to see strong delivery from our pipeline. In the past weeks, we announced results from 4 positive Phase III programs including 2 NMEs, tozorakimab and efzimfotase alfa. We continue to invest in our commercial capabilities, both to support ongoing launches and multiple future launches such as baxrostat, [indiscernible] and tozarakimab. In R&D, we continue to invest in our pipeline, including our transformative technologies. Please move to the next slide. The breadth of our business remains a competitive strength with a solid growth outlook across therapy areas and key markets. Oncology and Rare Disease saw strong double-digit growth, while high demand in R&I was offset by loss of exclusivity in CVRM. We saw strong performances across our key regions. Our largest market, the United States, grew at a double-digit percentage, benefiting from our investment behind recent launches with Europe and emerging markets growing at high single digits. Importantly, we continue to deliver impressive growth in the emerging markets with ex-China revenues up 9%, reflecting the benefit of our sustained presence in this market. Revenues in China increased by 2% with VBP implementation impacting Forxiga, Lynparza and roxadustat growth. We are confident in our growth outlook in China based on the positive 2026 and RDL outcomes. Next slide, please. In the third quarter, we saw a continuation of the successful clinical trial delivery seen in 2025. We announced 4 positive high-value programs, reinforcing the continued progress we are making towards our 2030 ambition and beyond. We look forward to discussing the significant potential of this readout during this call. And with that, I will hand over to Aradhana to talk you through our financials. Please advance to the next slide.

Thank you, Pascal, and good morning, and good afternoon, everyone. As usual, I will start with our reported P&L. Next slide, please. As Pascal has already highlighted, we saw very good top line momentum in the first quarter with total revenue increasing by 8%. Product revenue consisting of product sales and alliance revenue also increased 8% with continued growth seen across all key regions. Alliance revenue increased by 26%, reflecting our increased profit shares for our partnered products in HER2 and [indiscernible] in regions where our partners book product sales. Next slide, please. This is our core P&L. The core gross margin in Q1 was 83%. For the full year, we continue to anticipate a stable to slightly higher core gross margin versus 2025. Core R&D expenses increased by 8%, driven by continued acceleration and investment in our pipeline. The number of active clinical trials increased by 10% and the number of patients enrolled in our studies increased by 30% compared to Q1 last year as we continue to bring new innovative medicines to patients while creating value for our shareholders. As previously highlighted, we continue to invest in transformative technologies, including cell therapies and T cell engagers to drive growth also beyond 2030. As a percentage of total revenue, core R&D costs accounted for 23% in the first quarter. For the full year, we continue to expect core R&D costs to be at the upper end of the low 20s percentage range. Core SG&A cost increased by 7% in the first quarter. This was partly driven by prelaunch investments behind [indiscernible], which has a U.S. PDUFA date in the second quarter of 2026. As you've seen, we have had a great start to 2026 in terms of R&D with success in 4 high-value programs, including tozorakimab, which will require SG&A investment to maximize their potential. In addition, we have several other upcoming launches for products with high value potential, including baxtrostat, gamizestrant and tozorakimab, all of which will help drive growth through 2030 and beyond. Other operating income increased to $189 million with some nonrecurring milestones booked in the quarter. Core operating profit grew by 12%, reflecting a strong underlying performance. Core EPS grew by 5% to $2.58 with growth rate impacted by low tax rate in Q1 2025. Next slide, please. Cash flow from operating activities of $3.4 billion was a slight decline versus the same period last year due to large milestone received in Q1 2025, but partly offset by strong underlying performance. CapEx $600 million includes previously announced multiyear investments, such as our new ADC manufacturing facility in Singapore and our new manufacturing plant in Qingdao, China for an inhaled respiratory portfolio. We continue to anticipate CapEx to increase by around 1/3 in 2026. Deal payments of $1.1 billion include milestone payments to partner and an upfront payment for the Jakobi license agreement announced last year. We have now paid the last royalty payment for Forxiga. For the full year, we continue to anticipate milestone payments of around $2.5 billion relating to past transactions. The recent CSPC deal closed in April, so will be booked in the second quarter. Our capital allocation priorities remain unchanged. Net debt increased by around $2.5 billion in the quarter, driven by a payment of the second FY 2025 interim dividend in March. We are comfortable with our current level of gross debt. And as previously indicated, we anticipate core finance expenses to increase this year, driven by higher lease expense and lower interest income. Today, we are reiterating our full year guidance. Total revenue is anticipated to increase by mid- to high single-digit percentage and core EPS is anticipated to increase by low double-digit percentage at the constant exchange rates. Based on average March exchange rates, we anticipate a low single-digit positive FX impact on total revenue and a neutral impact on core EPS. In summary, a very strong financial performance in the quarter, and with the investments we are undertaking both in R&D and behind new launches, we are well placed to grow through 2030 and beyond. With that, I will hand over to Dave, who will take you through the business performance of our oncology business.

Thank you, Aradhana. Next slide, please. Oncology total revenues grew 16% in the first quarter to $6.8 billion with double-digit growth across all reported geographic segments. Performance in the U.S. and Europe was particularly strong with growth of 18% and 19% over the prior year, respectively, continuing the momentum demonstrated through 2025. Turning now to quarterly performance of our key medicines. Tagrisso grew 5% in the quarter to revenues of $1.8 billion. Performance was driven by robust demand across all stages of EGFR-mutated lung cancer in the U.S. and Europe, partially offset by higher than historic destocking in the U.S. In the frontline setting, Tagrisso remains the treatment of choice with an increasing proportion of physicians opting for the FLRT 2 combination. We anticipate continued growth over the balance of the year across all indications. Our foundational immuno-oncology assets Imfinzi and Imjudo delivered growth of 28% in aggregate, Infini growth of 30% was as in previous quarters, underpinned by robust demand growth across all regions. We are seeing an increasing contribution from more recent launches such as Matterhorn and gastric, Niagara in bladder and Adriatic in lung cancer, alongside continued growth in more established indications such as [indiscernible]. With continued strong demand for Imfinzi and Judo across indications, we are well positioned to sustain growth throughout the remainder of 2026. Calquence revenues grew 17% in the quarter to more than $900 million, with double-digit growth in all major regions. Focusing in on the U.S., Calquence continues to maintain its share leadership position in the frontline CLL setting, despite intense competition. Our finite regimen for frontline CLL based on AMPLIFY is gaining momentum in reimbursed European markets and driving incremental new patient starts. While too early to comment on the trajectory in the U.S., excitement is building among prescribers and we believe Amplify will be a key contributor to growth this year. Turning to HER2, which is now annualizing as a $5 billion brand on an alliance view we delivered growth of 34% in the quarter, which was balanced across regions. This growth reflects ongoing demand in both the HER2-positive and HER2 low breast indications. In China, the exceptional performance we saw through 2025 post-NRDL enlistment continues into 2026, with share gains in both HER2-positive and low breast cancers. We're also seeing encouraging early signs of adoption of NHER2 in first-line HER2-positive breast cancer in the U.S. following the DeSisto9 approval in December last year. We look forward to broadening our reach further with additional launches in the early HER2-positive breast cancer later this year. Truqap revenues of $198 million in the quarter represents 47% growth over the prior year. We expect some further growth to be delivered in ex U.S. markets, and we see U.S. market share at peak. Datroway revenues of $43 million in the first quarter reflect ongoing demand in the U.S. in later line EGFR mutated lung cancer with more than 1 in 3 third-line patients now treated with this medicine. Following its acceptance for priority review, we look forward to the U.S. approval of [indiscernible] Breast 02 later this quarter. This has the potential to drive significant further growth for Datroway given the differentiated profile demonstrated in patients with metastatic triple-negative breast cancer that are not candidates for immunotherapy, an area of high unmet need. After a robust first quarter performance, we are excited about the outlook for the remainder of the year as we continue to deliver transformative regimens to more patients across the globe. With that, please advance to the next slide, and then I'll hand over to Susan to cover key R&D highlights from the quarter.

Thank you, Dave. Earlier this month, we announced the positive results of the Phase III EMERALD- 3 trial. Building on the success of Himalaya in advanced liver cancer. EMERALD-3 now moves Imfinzi in combination with Imjudo into the earlier local regional setting with the goal of transforming outcomes for more patients with hepatocellular carcinoma. EMERALD-3 is a 3-arm trial, investigating whether the STRIDE regimen made up of a single priming dose of [indiscernible] together with regular interval dosing of Imfinzi with or without lenvatinib can improve outcomes when given before and then alongside standard of care transarterial chemoembolization, or taste. . Data from the primary analysis are very encouraging, demonstrating a statistically significant and clinically meaningful improvement in progression-free survival for the STRIDE plus lumber arm with a positive trend to overall survival. The STRIDE only arm also demonstrated a strong trend to both PFS and OS benefit, although this arm was not formally tested at this time. We await further follow-up and are excited by the potential EMERALD-3 offers for more than 200,000 patients with local regional HCC currently eligible for embolization. We look forward to presenting the data at ASCO. EMERALD-3 marks the beginning of a series of high-value Imfinzi readouts over the course of 2026. In the coming months, we expect results from Volga, which will complement our Niagara indication in muscle invasive bladder cancer and further reinforce our position in genitourinary cancers. Then in the second half of this year, we have 2 data sets that present opportunities to further broaden use of Imfinzi in lung cancer with Avanza aiming to improve outcomes and significantly expand in Fenza's reach in the first-line metastatic setting, and PACIFIC 9, which looks to consolidate and deepen our leadership in Stage 3 unresectable disease. Imfinzi is the current backbone of our immuno-oncology franchise, and we're excited by its potential to become standard of care across an even broader range of tumor types and settings. We're also excited to highlight several new developments from our oncology pipeline that will be presented at ASCO this year. Our in-house ADC program continues to progress at pace. We look forward to sharing more data on PaxiSam, our B7-H4 directed ADC in endometrial and ovarian cancers. And we're also excited to be moving forward with our plans to open 2 further Phase III trials for our folate receptor alpha-targeted ADC [indiscernible] in ovarian cancer later this year. We will also share further data for SunnyV, including 18.2 positive gastric cancer from a broad global population which supports the ongoing Phase III clarity gastric 1 trial now expected to read out in the second half of this year. Also at ASCO, additional evidence supports the use of our PD-1 TIGIT bispecific [indiscernible] in combination with HER2 in gastric cancer. Early phase data for [indiscernible] head and neck cancer will also demonstrate safety and efficacy in this indication. And finally, I want to highlight that we will present impressive first-in-human data for our PRMT5 inhibitor, AZAD3470 in a heavily pretreated classical Hodgkin's lymphoma population, strengthening our expanding hematology pipeline. ASCO 2026 looks set to be another significant congress for AstraZeneca. And with that, please advance to the next slide, and I'll pass over to Ruud to cover biopharmaceuticals performance.

Thanks, Susan. Next slide, please. Our Biopharmaceuticals total revenue was broadly stable in the quarter, with growth in key brands, mostly offsetting the anticipated headwinds from Brilinta, Farxiga and roxadustat. Overall, biopharmaceuticals total revenue declined by 2% to $5.8 billion. Our respiratory and immunology portfolio was up 7% to $2.3 billion. This performance was driven by our key brands, which grew 18%. Within the portfolio, Fasenra delivered another strong quarter, growing 11% to reach $483 million. This was supported by a strong uptake in China following its NRDL listing with revenues in emerging markets, up 63%. Breztri generated $353 million in revenue, growing by 13%. Earlier this month, Breztri achieved its first label expansion beyond COPD with U.S. approval for asthma. Breztri is the first and only triple therapy in asthma approved for patients aged 12 and older. Regulatory reviews continue in other countries. Tezspire continues to perform well and delivered $303 million in revenue, representing a growth rate of 34%. Tezspire is now approved for chronic rhinosinusitis with nasal polyps in all major markets following approval in Japan and China this quarter. Saphnelo grew 24% to achieve $171 million in revenue. The new subcutaneous formulation is now approved in Europe, the United States and Japan, which extends its reach to the large segment of patients who favor self-administration. 2026 marks a transition year for CVM as we navigate loss of exclusivity headwinds on ahead of the launch of several key pipeline medicines and new indications. CVRN total revenue for the first quarter stood at $3.3 billion, representing a decline of 6%. Farxiga total revenue fell 3% to $2.2 billion. Farxiga has a phased LOE profile and in quarter 1, that LOE effect was seen in established rest of the world and also with the implementation of VBP in China. As expected, generic manufacturers enter the U.S. market in April. Our U.S. markets continue to perform well, fueled by Farxiga's market share leadership within the fast-growing SGLT2 inhibitor class. [indiscernible] achieved global market leadership in the potassium binder class and $199 million in the quarter, reflecting growth of 26%. Our commercial teams are preparing for the launch of [indiscernible] later this year with the PDUFA date for FDA regulatory decisions set for quarter 2. If approved, baxastat will be the first adostron/cyntese inhibitor to serve patients with uncontrolled and resistant hypertension. In 2026, we anticipate gaining commercial access. And over time, we expect to see broader use across patients eligible for Part D reimbursement in line with the typical negotiation cycle. With the new approval for [indiscernible] and asthma, the anticipated [indiscernible] launch, the recent success of toseracumab Phase III COPD program and the upcoming results from [indiscernible] ATTR-CM trial we have much to look forward to across biopharmaceuticals this year. I will now hand over to Sharon to take us through the exciting tozorakimab readouts in more detail.

Thank you, Ruud. Next slide, please. I am delighted to share the significant progress from our respiratory pipeline this quarter with compelling new data that underscore our commitment to pioneering science and addressing the most urgent challenges in respiratory disease today and for the future. We recently reported high-level results from our 3 pivotal Phase III studies, and long-term extension study in our LUNA program studying tozorakimab in COPD, Oberon, Titania, Miranda and Prospero. This represents the most comprehensive Phase III program ever conducted for a COPD biologic, and the results reinforce our confidence in tosorakimab's potential to be a first and best-in-class treatment option for patients living with this devastating disease. COPD remains a critical area of unmet medical need. It is the third leading cause of death globally, claiming over 3 million lives each year. even when patients are an inhaled standard of care, approximately half still experienced exacerbations, which amplifies their risk of cardiovascular events, including heart attack, stroke or even death. Importantly, only 50% of patients live more than 3.5 years after their first severe COPD exacerbation. These statistics underscore why innovation in COPD is so urgently needed. What sets tozoracumab apart is its dual-acting mechanism and the breadth of our clinical program. This is a true AstraZeneca science success story. Over a decade ago, our scientists uncovered IL-33's 2 distinct forms and their role in COPD. Our research confirmed the reduced form of IL-33 activates immune cells through the SP2 pathway. They also discovered that IL-33 released from cells undergoes oxidation and converts to a different form, which activates the RAGE EGFR pathway and the cycle of mucus production in COPD. These discoveries inform the development of tozorakimab, a differentiated molecule, which uniquely inhibits the signaling of both, reducing the inflammation and breaking the mucus dysfunction cycle, which drive disease worsening. In Oberon and titania, tozorakimab achieved statistically significant and highly clinically meaningful reductions in the annualized rate of moderate-to-severe exacerbations. This efficacy was seen in former smokers and in the overall population, which included former and current smokers and had patients independent of eosinophil levels and lung function severity. Miranda, testing in every 2-week regimen showed clinically meaningful benefits and exacerbation reduction as well. These results are truly exciting, marking the first time a biologic has demonstrated efficacy in COPD in 3 pivotal trials that enrolled broad populations. These results are further supported by Prospero, the long-term extension study of Oberon and titania. While the narrower primary endpoint of severe exacerbations, those leading to hospitalization or death, did not reach statistical significance and former smokers, we observed a numerical reduction in this population and a nominally significant reduction in the overall population. Tozorakimab tosorakumab was well tolerated with a favorable safety profile across the entire program. We are working at pace to share these data with the regulatory authorities and the scientific community with approximately 6 billion biologic-eligible patients globally. Tozorakimab has the potential to address the broadest population of COPD patients. And with that, please proceed to the next slide, and I'll pass over to Marc to cover rare disease.

Thank you, Sharon. Can I get the next slide, please? Rare Disease delivered total revenue of $2.4 billion in quarter 1, up 15% year-over-year. This is driven by growth in neurology and metabolic diseases, increased patient demand and continued global expansion. If you recall, first quarter 2025 performance included transitory headwinds most notably tender market order timing for both Soliris and Strensiq. In the quarter, Ultomiris grew 18%, driven by patient demand across indications, including the competitive [indiscernible] and PNH markets. Soliris revenues continued to decline due to successful conversion to Ultomiris as well as biosimilar pressure. This was partially offset by favorable order timing in certain tender markets. Strensiq grew 43% year-on-year reflecting strong underlying demand and a favorable comparison versus the prior year. We saw demand growth for Koselugo, including the newly launched adult indication for NF1 PN patients. We continue to see great momentum across the rare disease portfolio. Please advance to the next slide. I'm delighted to announce a positive high-level results for Phase III programs in rare metabolic and renal diseases. Efzimfotase alfa, our next-generation enzyme replacement therapy demonstrated positive results from the global Phase III clinical program for patients with HPP. The Marbury trial in treatment-naive pediatric HPP patients met its primary endpoint showing meaningful improvements in bold health as well as other objective endpoints, including physical function and quality of life. In parallel, the [indiscernible] Phase III trial showed that [indiscernible] was well tolerated in children switching from Strensiq while maintaining benefit on bone health. In the [indiscernible] Phase III trial in adolescent and adult with [indiscernible] efzimfotase alfa demonstrated numerical improvements but did not achieve statistical significance in the primary endpoint of 6-minute walk test in patients who have been -- who have not been previously treated with Strensiq compared to placebo. The results show clinically meaningful impact on mobility, physical function, pain and fatigue that are key aspects of this heterogenous disease that are beyond one single endpoint such as the 6-minute walk test, the only approved adult endpoint. Efzimfotase alfa represent patients and third innovation improving upon Strensiq profile for a longer half life, more patient-friendly dosing and an improved manufacturing process. The Phase III trials were designed to reflect the broad symptomatology [indiscernible] and efzimfotase alfa's well positioned for global adoption by removing key barriers to access. There are approximately 14,000 addressable patients across the top 8 countries. Approximately 20% of these are pediatric cases, 60% adult with pediatric onset disease and 20% adult with adult onset disease. We will share data across the program with regulators and present at an upcoming medical meeting. We believe efzimfotase alfa represents a [indiscernible] sales opportunity of $3 billion to $5 billion. In addition, we recently announced positive high-level results from a prespecified interim analysis of the ICAN Phase III trial, which showed that Ultomiris met its primary endpoint, demonstrating a statistically significant and clinically meaningful reduction in proteinuria based on 24 hours urine protein creatinine ratio at week 34 in adults with IgAN who are at risk of disease progression. The primary endpoint of change from baseline in estimated glomerular filtration rate will be measured at week 106. Ultomiris demonstrated complete and sustained terminal complement inhibition with protein reduction seen as early as week 10. Benefits are consistent across patients, including those at higher risk of progression and with more inflammatory disease. Importantly, updated 2025 Cardio guidelines recommend using disease-modifying agents such as Ultomiris in combination with supportive medicine that manage a disease symptoms such as RAS or agility inhibitors. Across U.S., Japan and the EU5, there are over 560,000 patients diagnosed with [indiscernible] and 60% of patients would be eligible for [indiscernible] treatment based on proteinuria. We are confident this indication could reach blockbuster potential, given our established nephrology presence across AstraZeneca and Alexion and we are seeking accelerated approval in key markets. In addition, today, we disclosed the discontinuation of Ultomiris in CSA AKI high-risk patients with skin ischemia due to lack of consistent efficacy across CKD severities. And finally, I'm pleased to report that [indiscernible], our Phase III trial investigating the safety and efficacy of enable paratide in adults with chronic epoparatoodism will be presented at ECE in May and [indiscernible] our Phase III program of onselamumab in [indiscernible] mylodosis patients will be presented at ASCO in June. These presentations mark important milestone in bringing new therapeutic option to people living with rare diseases. And with that, please advance to the next slide, and I will hand back to Pascal.

Thank you, Mark. Next slide, please. We are off to a strong start with 4 meaningful programs readouts already delivered in 2026 and a risk catalyst pass across the rest of the year. As shown here, the volume of high-value readouts for the year is notable, collectively pointing to a risk-adjusted peak year revenue potential exceeding $10 billion. supporting growth of the company to 2030 and well beyond. Next slide, please. As you can see, our recent success is resulting in an extremely eventful year in 2026. We're excited to showcase our positive data from several programs at upcoming congresses, including ASCO and EDA. We're also expecting a significant wave of approvals including the potential first approval of 4 NMEs and 4 life cycle management indication. We also look forward to additional regulatory decisions in major markets to continue to bring our medicines to more patients across the globe. Next slide, please. In closing, Q1 delivered strong commercial momentum and excellent pipeline execution, reinforcing our growing confidence in achieving our 2030 ambition. With a broad portfolio, a deep pipeline and meaningful advances across multiple transformative technologies, we are well positioned to extend growth beyond 2013. And with that, please advance to the next slide, and we will move to the Q&A.

As Joris mentioned at the start of the call, and we will see if he's more successful than his predecessor R&D. Please limit the number of questions you ask to allow others a fair chance to participate. [Operator Instructions] And now let's move to the first question, which is from Richard Vosser at JPMorgan.

Two questions, please. First question on tosorekumab. Could you characterize how you see the product profile relative to DUPIXENT and Nicola? Do you think the breadth of activity sufficiently differentiates the product. So physicians wouldn't need to test for eosinophils anymore? And then a second question, just on the ramp of ENHERTU. Could you just give us a bit of color around the rollout and how we should think about the pace of uptake for the adjuvant setting and neoadjuvant setting in DB11,-DB05?

Thanks, Richard. So, Joris didn't go very far. You failed on the first step. Sharon, do you want to take this? And Ruud if you have anything you want to add later.

Sure. I'm happy to. So as you know, we announced the positive high-level results for tozorakimab in obron and titanium and Miranda. And in these Phase III studies, we were able to demonstrate that we had a statistically significant. And in the case of Oberon and Titania, highly clinically meaningful results. both in the primary and in the overall population. So our primary population was former smokers, our overall population included former and current smokers, patients across all blood eosinophil counts and all stages of lung function severity. Now we can't slice and dice those data until we present them at an upcoming medical meeting. But we are encouraged by the data that we have seen and we've characterized it as highly clinically meaningful in the case of Oberon and titania, and we are moving at pace to submit that to regulators.

Yes. And the only thing, Richard, I would like to add regarding the potential is that the current biologics in COPD are primarily for high use in the fields. These studies were done above 300 million I think the uniqueness as Sharon has shared is that this is across the eosinophil account of patients -- so whether in the end of the day, physicians want to test in COPD, the infill count is up to them, but we are hoping for a very broad label on the basis of the Oberon and titania data.

Yes. And I think really -- of course, it's left up to physicians, but we think we have a true oldcomers product from that viewpoint of the OS levels. Dave, do you want to take the [indiscernible] questions?

Yes, absolutely. Thank you very much. So at the highest level, in HER2 with DB clearly is bringing transformative benefit with PFS now exceeding 40 months. That has been very well received in our promotional efforts that we've been engaging in. We're seeing encouraging early adoption across a broad frontline population. So utilization both in hormone receptor negative and hormone receptor positive patients. We do, as you would expect, see academic HCPs are driving early adoption more so than you would see within the community within this first quarter post launch, but we will I look forward to continuing to see our efforts in the community. And I think importantly, we are seeing increased recognition of the importance of continuing in HER2 treatment for a prolonged duration with less consideration of this sort of maintenance notion, which I know was something that we had gotten some questions about coming out of ASCO. In terms of the early breast cancer studies with [indiscernible] and 11, I think they build really nicely on the existing confidence that exists within the HER2-positive space with 03, 09. And now these studies, we've got upcoming PDUFA dates here shortly, and I think that there's a lot of energy around both of those studies and incorporating them into practice.

Thanks, Dave. So the next question is from James Gordon at Barclays. Over to you, James.

Hopefully, you can hear me now. James Gordon for Barclays. The question was on [indiscernible] for hormonal breast cancer and the route of this being a $5 billion-plus product. So I know you've got a couple of angles. But one is the Serena 4 readout in the second half, but on that one, to what extent is failure of wishes persevere first-line metastatic ESR1 all-comers trial, mean you're more cautious on that readout? Like are there important differences like maybe patient enrichment or the potency of your drug or other factors that mean you still think you've got a good shot of this? Or is this quite a long shot based on [indiscernible]. And then the other angle, probably the bigger angle would be adjuvant hormonal breast cancer, which -- that could be a $20 billion plus category. But I think your [indiscernible] trial, which is like the analogs trial to [indiscernible] that's already up for approval in Q4 for Roche. That's only meant to have final data for 2013 and still recruiting. So is there a way you can still be a big winner here? Or is it looking tougher?

Okay. Thanks for the question. So in terms of the first-line metastatic hormone receptor positive patient population, obviously, we'll have to wait and see the PACEVRA data at ASCO. But remember that we've said that we do have a differentiated asset in [indiscernible], the effect size that we saw in the second-line setting was robust in both the ESR mutant and wild type. And we also have enriched the first-line patient population, hopefully enrich for a greater endocrine-sensitive population. . One key differentiation as well from the PACEVRA study for SERENA-4 is it's a much larger patient population. So we sized for an effect size that will still be clinically meaningful in that population. So that's why I think we need to look out for both what the safety and the efficacy data are for PACEVRA at ASCO. Moving on to the adjuvant population. Just as a reminder, we have 2 adjuvant studies, Cambria 1 and Cambria 2. So Cambria 1 study takes the patient population that's already had 2 to 5 years of CDK4/6 inhibition. So that's the, if you like, the prevalent patient population of E-positive and then Cambria 2 is in a setting that's more similar to [indiscernible], because it does allow for combination with CDK4/6 in the adjuvant setting. And given the benefit that's been seen with CDK4/6 inhibitors in the adjuvant setting, there's an increasing demand from patients treating physicians. to treat with CDK4/6 in that setting. So if you think about the combination of Cambria 1 and 2 together, I think we have the opportunity to get the largest slow share of the adjuvant patient population, given that and the success of Ladera, I think does show that, first of all, there's a positive proof of concept for the effect of these drugs in that setting. And given that we've got a very good profile with [indiscernible], I think that builds confidence on our likelihood of success in those settings.

Thank you, Susan. Next question is from Sachin Jain at Bank of America.

One topic we [indiscernible] transform question for both Sharon and Ruud. But for Sharon, we head into the Phase III, could you just remind us of a few factors. So could you remind us just half an SGLT usage at baseline -- and where do you think that will complicate across trial comparison versus the 30% benefit Anvita and Hanos-B? And then on the secondary subgroup, are you powered to be statistically significant if you repeat the Anvita benefit. And then just a quick one for Ruud. If you could just talk to the commercial relevance of both those points, cross trial benefit comparison and the secondary endpoint.

Thanks, Sachin. Sharon, do you want to start?

Sure. So Sachin, let me just clarify the question because there was a little bit of a skip. I think you were asking about the number of the rate of SGLT2 background therapy?

[indiscernible] and SGLT2 usage at baseline and where that complicates cross trial versus [indiscernible] 30% benefit and then the secondary [indiscernible] powering.

All right. So now we haven't disclosed the exact numbers there, but let me speak broadly about this. We always anticipated that the treatment landscape would evolve during the time that we're running the cardio transform study, and we designed a large study to account for that. the baseline standard of care treatments, and here, you've included SGLT2 and tafamidis. So stabilizer and SGLT2 are expected to have an impact on the event rate, but we previously extended our trial duration to account for that. If we look at the HELIOS-B study, the treatment effect with futisiran versus placebo looked very similar in trial participants who were on background tafamidis versus those who were not. So while we think background therapy should have an effect on event rates, we don't expect the differences in background therapy to have an effect on the overall treatment benefit. You also asked about secondary end points. As you know, we designed the secondary endpoints to evaluate different patient subsets. And 1 of those is patients on tafamidis versus those who are not. And if we are able to demonstrate statistical significance, and it depends on how far we go through the statistical analysis plan, we view this as the icing on the cake. Ruud, would you like to comment further?

Yes. Thank you so much. And regarding, let's say, the peak sales Sachin, we have indicated in 2024 during the Investor Day that we see this asset as a $5 billion-plus asset. I think, of course, as always, it's incredibly important to hit the primary endpoint, and the primary endpoint is different from the endpoint of in the [indiscernible], of course, here, we are talking about the change from baseline to a composite endpoint of cardiovascular death plus CV recurrent events up to 140 weeks. So that in itself, I think, is a very important part of the differentiation of [indiscernible] versus the competition. Now, as Sharon mentioned, every secondary we can hit will further differentiate our products from the competition. So let's wait and see, but we remain highly excited about the prospects of these assets.

Steve Scala with TD Cowen. Okay. We can't hear Steve, so we'll come back to Steve in a minute. Maybe we move to Graham Parry at Citi.

One on tozorakimab again. Just wondering if we -- you can confirm that we should interpret the way the headline press release was worded and your comments today to mean that the effect size across the different eosinophil groups is consistent across those groups. I think you talked just now about potentially having a broad label. So that would be the interpretation. And then secondly, could you just give us some sort of clarity as to what you think the implication of Prospero missing is and perhaps some rationalist how you could have such highly clinically meaningful data in the Miranda and overall trials without missing on the endpoint on Prospero. Thank you.

So I hope, Sharon, you got the second question because the line broke up a bit. And the first 1 I can quickly answer. We expect -- we hope our expectation is we will get a board level in credit [indiscernible],but we can't today disclose the results in each group. You will see this when we present the data. And the second question, Sharon, hopefully, you got it in full.

Yes, I did hear the question. So I'll just repeat that Prospero was the long-term extension study and that Hospira was unique from Oberon Titania and Miranda in that it had a different primary endpoint. It looks specifically at severe COPD exacerbations. Those that cause hospitalization and death over the duration of 104 weeks. We really look forward to sharing the data. This will be a component of our regulatory package. We are really delighted with the overall data that we've seen across the LUNA program. Prospero supports the clinical profile of tozorakimab, and we look forward to submitting our data in totality to the regulators as quickly as possible.

Thank you, Sharon. Next question is with Sarita Kapila with Morgan Stanley.

So you've had a number of successes for data across long in breast cancer as you've outlined. So how should we now think about the totality of the commercial opportunity? And are you confident in reaching multibillion peak sales for Data excluding Avanza -- and then just a quick 1 on [indiscernible]. How is the initial dialogue with the FDA be -- and is there scope for approval in the subgroup of adolescents and adults with pediatric onset, and perhaps you could quantify what percentage or how large this population is?

I think, Dave, you can take the second one. The first one [indiscernible]. But if you -- Sarita, if you go back to the script, I mean, maybe Marc, I'll repeat it, Marc gave the split of the various growth [indiscernible] adult onset. So the first question, Dave, do you want to go?

Yes. Sarita, I think that the best way to address this is that when we laid out a $5 billion plus ambition on Datroway, we continue to see the opportunity being just that. And -- we've got a series of really important readouts that are going to be happening over the course of the next several quarters. Obviously, we've got of OnzAR-TL07, TL08, but also we've got Tropin 115, and then that will be followed afterwards by Troponin 114 in a series of data studies incorporating with NextWave IO. So we've got quite a few programs underway. Lung cancer is obviously an important element of this. The work that we've done on QCS, we think, has positioned us well to be able to have multiple shots on goal within the AVANzAR study. And we're confident in the forecast that we've got at this time.

Yes, it's important to really keep in mind, our view hasn't changed but the potential of this agent since the time when Dave talked about it back a little while ago, of course, all these studies have to work in particular [indiscernible], our view hasn't changed. Marc, do you want to cover the secone one.

Yes. So maybe I'll take the second question first. In my prepared remarks, I had indicated that the pediatric cases are about 20%, the adult with pediatric onset would be 60%. And then the remaining 20% are covered by adult with adult onset. So these are -- this is basically the breakdown of the population suffering from HPP. In terms of data, as I've explained, we have 3 clinical trials, which we are going to submit to authorities. The first two are on the pediatric population. And the third one is on adolescent and adults, with -- as a primary end point [indiscernible] test, but there are many other endpoints, which are measured in this trial, and we have concluded that this study is clinically meaningful, and therefore, we're able to submit this data to the regulators.

Thank you, Marc. Rajan Sharma at Goldman Sachs.

So just a couple more on Datroway. Just wanted to understand the rationale for adding the QCS biomarker primary endpoint TLO-7 and then also including NTL08, does this increase the probability of success of the trials in your view? Or is it more about building a moat around the potential patient opportunity given that you have the biomarker? And then related to that, is there any reason why control arms across these Datroway lung trials, including may perform better or worse than you expected in a QCS positive population specifically?

Thanks for the question. So in terms of the rationale for including the biomarker in TL07, it's similar to the rationale for including it in Avanza based on the totality of data that we've seen so far, across multiple data sets. We've seen consistent improvement in performance for both PFS and OS in the biomarker-positive patient population, both as monotherapy and in combination with IO in a first-line setting. So that's the logic that says that it makes sense to include in TL07 as well. As we did with Avanza, our colleagues at Daiichi Sankyo went and approached the regulatory authorities had discussion about this approach. So similar for TOV similarly to there's an opportunity in the ITT and in the biomarker-positive patient population in TL07, which as a reminder, is in the PD-L1 less than 50% of the patient population. I think I've mentioned previously that for TL08, which is in the greater than 50% patient population, given that that's a smaller segment already. the numbers that are accrued in that trial means that it makes sense to only include that as a secondary endpoint, not part of the primary analysis. But of course, assuming that Avanza does show an improvement in the biomarker positive, of course, everybody, including regulators will want to know what the performance is in the biomarker-positive patient population. So I hope that addresses your question about why we're doing it in TL-07 and TL08 and why it's different in the statistical analysis in TL07 versus 08. In terms of your question about event rate, the event rates for these trials are determined by the event rate in the overall ITT patient population. So whilst it's possible that the patient population that's biomarker positive has a different event rate, that is what determines the cut point. So it's really the event rate in the overall population that's determining when we can do the data cutoff and therefore, report the results.

And we have no way to predict how the control arm will behave, right? So they have to wait for the end of the study. The next question is Michael Leuchten with Jefferies, over to you.

One question maybe on the delays. So you've got a TL07 delay just linking back to the last questions because of the implementation of CS. Just wondering if you could talk to how complicated it is to run the test over existing tissue samples and whether that could slip any further or whether that's a firm view on the readout. And then question on [indiscernible] there's also the delay here, what's driving that, please?

So the timing of the results for TL07, I'll just based on the requirements for implementation of the biomarker within the clinical trial. That obviously requires an amendment and the other aspects of that. We have to actually sort of run the analysis on the samples that are available. There's no further delay to the event rate on. TL07.

Maybe, Michael, also just one of the maybe questions that's embedded within your question gets to the commercial readiness and how we think about testing in a post-approval world, we've been working really diligently to set up and be ready for QCS across the globe through a combination of central labs, but also decentralized testing work that we're doing. There's a lot of enthusiasm across regions to incorporate computational pathology into the way in which care is being delivered. And it also gets to the previous question that Rajan asked. I mean in many respects, you incorporate QCS into these programs because if it works and truly helps select patients, it's very differentiated for the program.

Yes, it's a really important point. And we've made that point before, but maybe just to remind you, if you assume that the ITT population will be positive, it's possible to assume that the QCS population might be even more positive in the positive scenario overall, of course. So in the U.S., we would expect IT use everywhere. In some countries where payers are more difficult and QCS gives us another chance to get reimbursement if we cannot achieve it in the ITT population. So it's really -- we have 2 shots on goal in type of reimbursement. So next question is [indiscernible].

So first of all, the -- just remind you that [indiscernible] is not an event-based trial, but a time-bound trial. And as the trial recruited faster than we expected, in order to reach the target medium exposure of the trial we decided to extend the study by 6 months. It's not an event based, but we wanted to return to the targeted medium exposure.

Matt Weston, UBS.

Two questions, please, if I can, on [indiscernible]. The first is now that tafamidis generics are delayed to 2031. And if the combo is superior in cardio transforms, is it realistic to expect reimbursement of a double-branded regimen in that setting? And then the second question is around [indiscernible] in ATTR. One of your other differentiations potentially is going to be the home administration claim in the U.S. So can you update us on the commercial performance in the U.S. market in the PN setting, so we can understand how advantageous home administration really is.

Thank you, Matthew, for both questions. First of all, regarding the combination. Of course, it fully depends in my view and our view on the size of the effect, the effect size is very, very substantial. I truly believe that payers, certainly in the United States, will be open to reimburse both branded products for this debilitating disease. So let's not forget that the mortality rate of patients with anti-TRCM is very high. So once again, if the trial is going to show very substantial benefit for the combination. I believe that the payers, the reimbursement authorities will certainly consider this for -- in order to reimburse it. Regarding the PN indication, I think overall, we are quite happy how it goes. It's very encouraging. There are a lot of patients with a so-called mixed phenotype certainly in the United States. of course, with the registration of the competitors also in the CM trial is not always to capture all those patients. But if you look at pure PN patients, we are clearly, clearly leading the pack here. You are mentioning the home administration for many patients. That's an ideal a way in order to get the medicine because there's no need to go at least 4 times a year to a hospital in order to get the drug administered by the physician. So I think the combination of a higher quality of life or a better quality of life, home administration and a very strong efficacy in general, I think, is one of the reasons we see a very strong uptake in the United States and in other countries for the PN indication.

Peter Verdult at Exane.

Pete here from BNP. Just Shannon Ruud, could we come back to Tosquesorry to labor the point, but just coming at a different angle. Just wanted to explore any potential upside scenarios to your $3 billion to $5 billion peak sales assumptions. So are you assuming that you will see IL-33 competition or competitors eventually making to the market when you -- when you provide that peak sales target? And do you have any plans to explore Toso beyond COPD or lower track refractory disease, I'm thinking maybe nasal polyps or bronchiectasis. And then just a quick clarification, Sharon, on the [indiscernible] question earlier. Am I right in thinking that the endpoint there was a bit different to [indiscernible].

Thank you, Peter. So Sharon, do you want to start with the second one, and Ruud you can go for the first one.

Sure. Yes. So you're spot on. the endpoint for Prospero was different than for Oberon and Titania. And Prospero, we specifically looked at selectively severe exacerbations, which is different than Titania that looked at moderate-to-severe exacerbations. The overall trial population that we enrolled in our comprehensive LUNA program is different from what competitor molecules did -- and it really provides us with a point of differentiation for tozirakimab. We have a differentiated molecule in terms of its bifunctional inhibition, and we also have a differentiated clinical trial program. Ruud, would you like to take the rest?

Yes, of course. So first of all, Peter, we have indicated once again that this product, in our view, is a $3 billion to $5 billion opportunity in COPD alone. Of course, the competitive environment has changed somewhat, and we don't know exactly what they are going to do moving forward. Having said that, based on results, of course, we are also thinking about potential other indications. You are mentioning from [indiscernible], potentially asthma. We haven't taken any decision yet on that. But if everything moves well, of course, we will have a look, but it makes sense also to move to tozorakimab in other indications where there's still a high medical need. Now on top of that, overall, the bio penetration of the current biologics in COPD is still relatively limited, below the 10%. So it also shows the potential in COPD, which is a very heterogeneous disease, in order to use a complete new biologic specifically designed for COPD in order to capture the full potential in COPD.

Sorry, Peter, did you want to say something? All right. Good. Christopher Uhde, SEB.

So my first is on MFN, if you wouldn't mind commenting. So how are you forecasting the future impact, let's say, across the 7 major markets? Or how would you recommend we do it perhaps is the question you'll answer. And then is this for -- should we be thinking about it applying to only future launches or some of the competitors have said? And then on IL-5, we've got a competing long-acting IL-5 that's launched and tracking rapid growth. So Ruud, what are you seeing on the competition? What are your thoughts then on the long-term future, I guess that parts for Sharon of the role of IL-5 in the RNI therapeutic area and how are you working to adapt to play a key part in that going forward?

Yes. Let me take the first one -- or the second one, sorry, the IL-5. Yes. First of all, we are very pleased with the performance. Now for quite some time, of Fasenra, it's clearly the leading in the class. I think the EGPA launch in countries like Japan, United States have been very successful. -- equally, of course, the class is changing somewhat. It's now a long-acting NT05. Having said that, the Nimble study was not specifically successful regarding the switch from Fasenra to the long-acting one. It was even getting worse. So I think what we need to do is to cement our position as the leading IL05. I think the molecule is doing extremely well. I think the mode of action, which sometimes forget that is fundamentally different from the other anti-IL-5s, we are depleting using the fills, and we have seen very, very strong traction across the world. And there's no reason to believe that will not continue. And last but not least, what I said in my prepared remarks, we have just launched Fasenra in China. China, there's a high unmet medical need. and the potential of a sun rate in China is very, very substantial as well.

Sure. So building on that route, I'll just restate that -- we have a lot of faith in Fasenra. It's a fantastic molecule. It provides targeted complete and fast sustained eosinophil removal effectively treating EOS inflammation and reducing the risk for patients. We've got a winner in Fasenra, and we have an 8-week dosing regimen that delivers that sustained control and really stands out for its high adherence. We've got about 80% to 90% of patients remaining on Fasenra through our pivotal studies, which is really remarkable as well as in our real-world studies, and it remains the only biologic with clinical evidence proven to reduce for both oral and inhaled background therapy. So we've got a strong molecule there. As we think about future growth in the portfolio, building on our success in Fasenra is part of our early strategy. I won't comment further on molecules that sit in our discovery pipeline, but we think about how to continue to leverage the success that we've seen in this program.

So the first question, I mean you can take a very conservative approach and remove the 7-plus [indiscernible] G7, I mean G7 being 6 countries and 2 from the forecast, if you want a very, very conservative approach. knowing that the last 2 are smaller markets. But we are working very hard, not only we, but the whole industry to improve the access and pricing environment in all of those countries. I should remind you all that it's only for new products -- future new products. And it will also be different product by product, country by country in terms of what is the gap between GDP per capita adjusted price in that country versus the U.S. But ultimately, our goal is to launch those products in every single market and improve the access environment. We have time to do this because new products will not be launched immediately. You've seen some movements in the U.K. already. discussions based on the 301 investigation, we'll start with other countries. I think in the next few weeks or months. We ourselves in the whole industry talking to countries and explaining the importance of improved access, not only for patients but also for investments in R&D and in particular in R&D in their respective countries. And we are getting positive response in some countries and more wait and see in other countries. But we have -- this is going to play out over the next 18 months, 2 years. So we have time to hopefully reshape the environment. So I've given you the most conservative approach in term of forecasting, but I don't think it's going to be like this. And as it is today, you have to remember the whole of Europe represents 20% of our global sales. So take a fragment out of this. This is not huge. And so we truly hope we are going to get better pricing and better access and be able to launch our products everywhere, which is, of course, the ultimate goal. Seamus Fernandez, Guggenheim.

So our question is actually on the positioning of the GLP-1 and how you're thinking about that. So can you maybe just walk us through how the upcoming ADA is really going to help us fully derisk your strategy in this space. Maybe help us understand the safety supporting the aggressive advancement into Phase III. And maybe if you could just specifically comment on whether these data are likely to convince investors that product half-life is key to differentiation on tolerability over and above planned titration scheme. So just trying to get an understanding of how these data coming at ADA are really going to wrap around the very broad Phase III program that you've initiated.

Yes. Thank you, Seamus. This one is for Sharon. And maybe Ruud can also jump in. I just want to be clear, fully derisked is a bit ambitious. We will fully derisk when we are at the end of the Phase III program, where we are moving as fast as we come into Phase III. So over to you, Sharon.

Yes. Thank you for the question, Seamus. As you know, those data are at ADA in June. So I cannot tell you what the data say the conference organizers would frown on that. But we did announce that we completed the Phase IIb trials for elecoglipron and that the data that we saw in those Phase IIb trials, one for obesity and one for patients with type 2 diabetes. gave us the confidence that we need to move into a very comprehensive Phase III development program. We have dual goals there. We're looking at both weight loss efficacy and we're also looking at outcome benefits, which are key drivers for us because we are focused not solely on weight loss, but on being able to address complex interrelated comorbidities. And AstraZeneca is in a unique position with our broad portfolio, we are ideally suited to creating both monotherapies and fixed-dose combinations with elecoglipron that allow us to address comorbid disease. So at ADA, we look forward to sharing the data and continuing this conversation. But what we saw in those data gave us the confidence that we needed to fully invest in our comprehensive program.

No, there's not a lot to add to what Sharon has said. I think the focus on outcomes, I think our strength with fixed dose combinations, and we have articulated a few of those potential combinations and one of them is clearly with our SDLT2 Farxiga. And last but not least, I think also AstraZeneca is quite uniquely positioned regarding our global footprint. We have a very strong presence, as we all know, in the international markets, and there's still an incurable high unmet medical need in those markets regarding obesity treatment, but clearly also diabetes.

We have a very ambitious Phase III program that is excellent, really. The team has done an amazing job. And so we have a very, very strong data set assuming, of course, the studies are positive, which we believe we have a good chance for that, of course, but we will have a very strong set of data across a very broad Phase III program to launch this product. So next question is from Luisa Hector at Berenberg.

A couple, please. So on canadestrant, are there interim analyses still pending for the Cambrias or even Serena core? And then given that we've had some discussion on Phase III trials, which are in flight, but you've been making some changes such as TL07, 08, I wonder whether you could give us some more color around your work with the FDA on real-time clinical trials because I see Astra mentioned as 1 of 2 companies working with the FDA there. So what kind of benefits could this ultimately bring in terms of timing and savings.

[indiscernible]. The question is really a real-time collaboration -- study collaboration with [indiscernible] .

Yes, sure. Thanks for the question, Luisa. So for interim analysis, you know we don't comment on those, so I can't really address that question anymore. For the real-time clinical trials, I think this is an exciting first step towards this future. So the trial that we are collaborating with the FDA on is the Traverse trial, which is with well establishments and calabrutinib in a mantle-cell lymphoma setting. So what this enables us to do is literally to the -- as the adverse events and the things come in, will get notified simultaneously with the FDA. So I think this will enable us to have learnings. I think the opportunity, though, is in a future world, where you're not submitting based on documents, but you are submitting based on access to data. This could save time in terms of preparation for submissions. and also time from the regulatory side in review of those submissions because the various analysis can be done. And then you can spend more time on the discussions with the agency about the context and the relevance of the data and the impact that that's going to have on treatment outcomes. So the hope is that this will lay the groundwork for that collaboration, and we're very happy to be partnering with the FDA in that regard and at the forefront of learning here.

Thank you, Susan. Maybe we could try again Steve Scala if Steve is back. Can you hear me, Steve. Okay. he has technical difficulties. Let's move to Mattias Häggblom at Handelsbanken.

One question, please. Can you talk about CAR-T and specifically, how you feel about the [indiscernible] program, but also [indiscernible] fast CAR as a platform in light of industry's rapidly growing interest [indiscernible].

So the line was not very good, but hopefully, Susan, you got it. It's about [indiscernible] 0, but I'm not sure that [indiscernible].

I just want to clarify the question a little bit. I think you were asking about how the fast CAR process helps the differentiation of [indiscernible] on to the lead product. Did I get that right? So I'll answer what I thought the question was. So one of the differentiations of AZD0120 is that it's developed with this [indiscernible] process, which enables the ex vivo growth of the cells in a 3-day process, which means that you can get a turnaround time reliably. in around a 16-day time frame because after the cells have been produced, there's still some quality testing that needs to be done before the cells are shipped to the patient. That reliable and shorter delivery time is really important for sites and for the operationalization. But there were other factors that are involved in here as well, you end up giving a lower dose and you give a lower dose of fitter T cells then it can then expand in the patient's body in vivo more rapidly. What that also delivers is a predictable time of onset of any cytokine release syndrome and enable it to be positioned as a potentially outpatient treatment because people know what the timing of the cytokine release syndromes can be prepared for that. And then the patient can go back after that period of time. So it's not just the fast CAR process in itself. It also is the dose that you end up with and the timing of the CRS that also make it differentiated. I think the other factor, of course, is that it's a dual CAR. It's got CD19 and BCMA targeting. We think that's important for avoidance of the escape mechanisms from dawn regulation of one target or the other. So overall, we're delighted with the profile that we've got with 120. It was presented in detail at the ASH meeting, and we now have ongoing [indiscernible] study Phase III study in later line multiple myeloma and you'll see further studies in the coming months as we open up this program more broadly.

Thank you, Susan. The next question is from Simon Baker of Redburn.

Just one from me, if I may, please, for Dave. I was wondering if you could give us an idea of the underlying demand growth for Tagrisso -- as you said, it was distorted by wholesale destocking. And related to that, is that wholesale destocking specific to Tagrisso? Or are you seeing that anywhere else in the portfolio?

Thanks, Simon, for the question. Just within the U.S., we have really seen Tagrisso with strong frontline leadership just to build and quantify some of the comments that I made in the prepared remarks. The demand growth for the quarter for Tagrisso was mid-teens. And so you can see that the really truly on a higher-than-historical destocking levels is what brought the net results down to where they were. Now specific to your question, we have seen some suggestion of this on other orals, but it didn't include [indiscernible] that could be because of a buildup for Amplify. So not entirely sure, but we are seeing some destocking across the oral agents that's taking place, but it was particularly noteworthy on Tagrisso. I think the most important piece, though, is that I don't see that going any further down. The demand growth is very strong. We're seeing a clear preference for FLORA too, very importantly, on Mariposa we have not seen any impact from the subcutaneous launch on U.S. Tagrisso shares. So the subcutaneous launch is cannibalizing IV, but it is not having impact on Tagrisso shares. And by the way, that same is true in Germany and in Japan.

Thank you, Dave. And the last question is Justin Smith at Bernstein. Over to you, Justin.

I've got one for Ruud. Ruud, if I remember correctly, during the August call last year post ESC, back to that, you said it could be above $5 billion. It could be above $10 billion time would tell. Just wondered over 6 months on for that, if those remarks are the same or if you would qualify those remarks at all?

Yes. No, I think they are still the same. So once again, what we have indicated during the Investor Day that this is potentially a $5 billion assets. Let's not forget that we're investigating -- and the $5 billion is built roughly [indiscernible] combination. That study will read out beyond 2027, and the other 1 is the mono component, but we are also looking into CKD for Bacastat. So there are 4 other indications which potentially, if successful, can move that number up to potentially $10 billion, and that view hasn't changed at all.

Very good. Let's end on that, Justin, you're making Ruud nervous. We're moving into budget timing. So [indiscernible] is definitely a big product, and we're all excited to see it launch in many countries very soon. So thank you, everybody. Thank you for your great questions and for your interest in our company, and we wish you a good rest of the day.