Bio-Techne Corporation (TECH) Earnings Call Transcript & Summary
May 29, 2024
Earnings Call Speaker Segments
Puneet Souda
analystAll right. Great. Good morning, everyone. I'm Puneet Souda. I cover life science tools and diagnostics here at Leerink. My pleasure to be hosting the next team here from Bio-Techne, CEO, Kim Kelderman. Kim, glad to have you here at our conference.
Kim Kelderman
executiveYes. Thank you, Puneet, and thanks for having us, obviously, in this place. A full place.
Puneet Souda
analystSo as we go through the conversation, please send me questions if you have, and I'll try to cover as we go.
Puneet Souda
analystMaybe Kim, just to start off a bit on the product segments that you serve, you got the RUO antibodies, the cytokines, the cell and gene therapy, and Protein Sciences, and the diagnostic business as well. I mean the quarter came in slightly better at 2% organic. Maybe take a minute and tell us where you feel more confident with the segments, which businesses, which product segments where you're more confident on the recovery versus the rest and where it could take a little bit longer.
Kim Kelderman
executiveThanks for the question, Puneet. Yes, let's quickly recap the quarter Q3, which is the calendar Q1 for us. Came in at the 2%, you mentioned, basically a combination of the Protein Sciences segment coming in at negative 1% and Diagnostics and Genomics at 10% growth. That would be 16% growth, including the Lunaphore acquisition. And that actually kind of got us to the results we looked at. We had kind of mentioned that this quarter was going to be in that range just because we had discussed the headwinds the quarter earlier, headwinds being the funding in pharma, biopharma as well as the China markets. We've also indicated that we feel de-stocking was behind us at the end of the calendar year. And that's exactly how it came in. So the result is good. It's all relative, obviously. And we did so in a very efficient way. I think we had an increase of 280 basis points year-over-year on the bottom line and resulting at 33% EBITDA. And yes, we saw some of those green shoots that we talked about, right? One was in -- through our talks in China about funding and one was or is -- at that time, we saw one or 2 good months as it comes to biotech funding. And by now, we know that it's 4 months of reasonable results in biotech funding, right, and now that everybody is looking at relatively similar numbers there. But 4 months is obviously more encouraging than 2 months by now. It still is not a trend, and it still doesn't indicate a V-shaped recovery. But it does indicate that there is some strength building, which we are very enthusiastic about, right? And we do know that once that funding starts improving, that it takes a couple of quarters to trickle down to the life science tools companies, including ours. But that eventually will end up there. And if you then think about which portfolio we are most enthusiastic about for an earlier recovery, that would be the consumables, right? Our consumables are the ones that get pulled through. And we know that if there's new funding, people switch their equipment back on and start pulling through the consumables and/or they start their projects or restart their projects, and that could also pull through our core reagents, right? And that's where we feel that the recovery would be. And that would be where we've been most [ suggestive ] about short term.
Puneet Souda
analystAnd you talked about the biotech funding. I mean now 4 months versus -- so we saw it sort of in the first quarter. On the consumable side, how long does it take for that to flow? And wondering if you're already seeing some of these signs from biotech funding?
Kim Kelderman
executiveIt's hard to say if it's from the new funding or whether it was from programs still running. Typically, you and I last talked also in a beautiful location. Typically, we feel that if funding gets released, it will shorter-term impact and pull through the reagents versus equipment because there's typically a little bit more scrutiny on what instruments shall we buy and getting the right approvals internally before that starts pulling through. So we always say 2, plus/minus 1 quarter, but it could well be that in a moment, you switch, get funding. It will take a quarter or 2 to pull through to the agents or start buying the agents and then a quarter of -- 3 or 4 quarters to get the funding to really end up in revenue for the life science tools if it comes to equipment.
Puneet Souda
analystGot it. Okay. And what are you hearing from the academic customers? And maybe just -- I know you talked about this with biotech customers. But yes, what are you hearing from the academic side?
Kim Kelderman
executiveAcademic side has been relatively stable, right? Yes, there are some ups and downs in different countries around the world, but I would call it stable in general with the HORIZON funding, with the NIH funding in the U.S. And we feel that we've done actually pretty well in academic. As you know, we've originally as a company been doing really well in pharma, biopharma. But with the lull in funding for biopharma, I must give compliments to our sales team flexing into the academic sector. And we've done relatively well there. We have -- we had flat growth. That was on a year ago, a quarter where there was a mid-double-digits growth in academic in Europe. So we had a tough comparable and still ended up flat. And then it is the low single digits in the biopharma side that, of course, was driven mainly because of cell and gene therapy. So if you look at those 2, the academic side has been very stable. And we think that we will have some benefits from now being more able to sell in the academic because of this lull in the last year. So I think we will benefit from a continuous healthy revenue stream from the academic side.
Puneet Souda
analystGot it. One of the major questions for Bio-Techne, when we look historically, obviously, 2023 is sort of rough patch for the industry. But historically, you have grown low double digits top line organic growth. I know, look, fiscal '24 isn't over yet. But maybe if you just sort of look out next couple of quarters, do you think we can start to get back to that historical growth pattern for in fiscal '25 maybe?
Kim Kelderman
executiveI think our entitlements, right, our long-term view is certainly to be in the mid-double-digits growth, right? So then the question is how quickly do you get there? And I think that's actually a question for everybody too, on the front of their mind, if you think about it. But the only answer that is really achievable, if you don't know when funding and when economic -- the economy turns, is to talk about relative performance. And we have, over the last couple of quarters, throughout the whole last 5 quarters, actually, we have continued to outperform our peer group by anywhere between 500 and 1,000 basis points. Of course, the peer group moves -- kind of like indicates how market is growing. So we could translate that to 500 to 1,000 basis points better than market. So then it basically gets paced by where the market sits, right? So historically, the market sits anywhere between 5% and 7% of growth, and that's when we sit in the mid-double digits. And on the way there, at some point, we will cross the double-digit line. That's when we'll get back to the -- to those double digits. When exactly is really hard to say because we have identified China as well as biopharma funding to be the gatekeepers of that.
Puneet Souda
analystBut at least the comps should be getting easier going forward and...
Kim Kelderman
executiveThat's a given. Yes. We have Q4, which we are now in, right, where the China comp is still pretty significant. And that was just because of one of these fund -- 2022 fund -- calendar year 2022 fund rolled in and became a peak of instrument sales for Bio-Techne exactly 1 year ago. So we still have one tough quarter. And from there, it's clear that the comparables will be easier.
Puneet Souda
analystOkay. I want to come back to China. But before that, maybe just let's touch on the Protein Sciences segment. The RUO antibody market, based on what you saw in the quarter, I mean, and what we heard from peers, it was a softer market. But maybe just tell us a little bit -- and that's no surprise given the times of recovery still. Maybe just update what are you seeing in that side of the business? What are some of the green shoots? What gives you confidence in overall the research use-only antibodies market?
Kim Kelderman
executiveYes. I think that, as you know, the antibody market is about $3 billion. We enjoy a 5% market share. I think we've very effectively competed in just core products over the last decade. We've certainly have a fantastic library of antibodies and a very innovative smart team that creates new antibodies consistently and continuously. Very good value proposition. So that's the reason why we, I think, have outperformed the market slightly over a long time period. Green shoots, I must say that we were positively surprised to see antibodies, the antibody business, growing by 30% almost in China last quarter. And that's definitely a green shoot for us. Overall, core reagents were 20% plus in China. And then we are also very optimistic about us enlarging our addressable market by launching in the coming months the GMP antibodies. That would be adding a 20% market share, and we would be one of the earliest to go in, early ones to go into that market, and compete effectively just like we've done at the -- with the protein GMP side.
Puneet Souda
analystDo you -- what's the sort of growth rate that you expect in longer term for this market? And I'm asking that because competitively speaking, there were some acquisitions and they are with some of your larger peers now. Does that change the makeup of the market? What do you expect to be sort of the long-term growth rate for the RUO antibody side?
Kim Kelderman
executiveRUO antibodies. The overall, I think that market is typically anywhere between 5% and 10% growth, basically mid-single digits. I'd say it grows mid-single digits, and we would perform anywhere between mid and high single digits. So that means we're still making -- taking market share. And I think, first of all, it's a very fragmented market, right? So there's many different pockets where you can build your strength. And I think that, yes, we have a lot of respect for the larger companies in the life science tools. But we're nimble. We're really well connected to the customer. We have a tremendous know-how or technology know-how. But also, the products have the right consistency in bioactivity that can just, on their own, outcompete. So with a good sales team and a good discipline behind it, I think that we will continue to be able to perform slightly better than our peers.
Puneet Souda
analystWhen you look at -- just want to touch on instruments briefly, Ella, [ Rez ], other instruments that you have for immunoassays, and I think it's still the only automated Western blot solution on the market. Tell us a little bit about what are you seeing on that front? Are you seeing sort of recovery? Or do you expect that to be more gated still, just given sort of the consumables pick up first and then instrumentation?
Kim Kelderman
executiveOverall, the consumables pick up first. Instrumentation will be too. But on specific product lines, it might differ a little bit. We had a tremendous quarter in West. And I think the theme of automating clunky and/or manual processes is going to continue to resonate with customers. Even under economic pressure or maybe especially under economic pressure because overhead is not cheaper, right? And you want to do your experiment maybe overnight, highly automated, and you want it to be consistent. So the automation product lines we have in ProteinSimple all have a wonderful value proposition in that way. Yes, and I think that overall, yes, it will -- the utilization of these -- of that equipment that is in the market will increase, and then new boxes will be bought. But in West, the one that you specifically mentioned, I think there, we have still a long way to go. And we could see that pick up first when it comes to the automated product lines.
Puneet Souda
analystLet's shift gears to China. There's obviously talk of stimulus there. You have -- I mean, now the footprint is smaller. But you -- maybe just talk to us in terms of the expectations from stimulus coming all the way to sort of the consumables and products you serve. And what's your long-term view on China? Because I think that still is a question just given what had happened sort of last year.
Kim Kelderman
executiveYes, it's a great question, especially because there is no easy definitive answer, right? So I think overall, if you look big picture, China, 1.2 billion people, health care, high on the agenda. There is a certain trend to wanting to be independent from -- if it comes to vaccines or medications. So there is a lot of activity in the territory, and we can definitely help boosting the output there. Again, automation is important. Having the right high-quality reagents and ingredients is important, and that's what we're strong at. We -- just in case there is going to be more constraints on what you can buy or sell into China, what you can buy if you're in China, we have a China-for-China facility. We built a bigger one with GMP capabilities. That is in process. And then if it comes to the specific fundings, we're zooming into this year's funding. When and how it gets distributed is still somewhat fluid, but we do see some traction if it comes to inbound requests, right, for our sales force to already start spec-ing which instruments and which reagents would be the best. So we see some traction in dialogue. And then the last data point I can give you is that when a similar program was launched in 2022, it had great -- it gave us great traction. And that's why we still have one tough comparable in this quarter because that was a funding cycle that really boosted our results.
Puneet Souda
analystAnd when you think about China-for-China production, is it largely focused on GMP side? Or is it -- maybe just walk us through sort of what's on the priority level.
Kim Kelderman
executiveI think the -- so overall, we could basically follow demand in the facility, right? But what you want to do is be smart if it comes to which -- what are the best products to get to achieve the highest price and where is demand in the market. And I think there is a variety of choices on many of these ingredients but not as many if it comes to the GMP label. And we have that ability, that muscle already trained, if you will, right, in our other locations. We have a GMP small molecule facility in the U.K. We have a GMP proteins in the U.S. and are about to launch GMP antibodies. So this whole GMP process is fairly familiar to us. And why not differentiate with something you are pretty good at and others still have to figure out, if you will?
Puneet Souda
analystGood point. Let's switch to cell and gene therapy, an important growth driver for you. And I want to talk within that Wilson Wolf as well. But maybe as you pointed out, GMP is a strength. Companies came to you for proteins and now they want more of it, right? So in the third quarter, I think it was up -- GMP was up 40%, I believe. One question we continue to get from investors is how much of this is sort of onetime or large orders versus run rate business? Maybe just talk to us about sort of where you are and how do you see the order progression.
Kim Kelderman
executiveYes. Thank you for the question. So overall, our cell and gene therapy business is at a $80 million run rate, grew 30%. The GMP component of it is at a $60 million run rate and grew 40%. So that's -- it's good. That's driving some of the growth, and that's also where we invested over the last couple of years, so it's good to see a correlation. And then you...
Puneet Souda
analystYes, I mean, I would say it's more on the order progression. So are these -- there's some lumpiness sometimes in these orders.
Kim Kelderman
executiveRight. So there are customers that are further down their clinical stages, and we do not have customers yet in clinical, where there is a continuous demand. So if you go into the different clinical studies, there is some lumpiness to the larger orders. This quarter, the 40% was a result of both, however. Meaning, yes, we had a larger order, which is a good indication that things are picking up again. But if we look at the rest of the funnel, which is around 400 customers, we also saw a 30%-plus growth across the funnel. So that shows overall health of activity. And then it becomes not just like -- can you get more large orders or more grow these different parts of funnels in different ways? Our funnel overall is healthy, so the only thing we really have to focus on is adding new customers to the fund.
Puneet Souda
analystGot it. Okay. Just wanted to follow up on Wilson Wolf. Maybe tell us how well the product is baked into the current autologous CAR-Ts out there either commercially on the market or the ones that are in the pipelines. I mean there, we're hearing good things about this bioreactor. But maybe just help us understand where the adoption of this product sits. And just remind us again on the original targets that you had that would trigger the acquisition for this.
Kim Kelderman
executiveYes. I'll take them one by one. The -- so overall, the Wilson Wolf main product is the GRx. And the GRx is more or less a bioreactor with a nifty patented permeable bottom, which makes it possible for oxygen to get in and get to the cells in a very efficient way. It makes them happy and makes them also want to multiply, which is exactly what you want with a cell therapy. The -- we own 20% of it for -- and we paid $257 million. There are other triggers to buy it by the other 80% for $1 billion earlier. And there's a revenue trigger as well as an EBITDA trigger. And if those do not get triggered, we would, at the latest, own the asset on December 31, 2027. Very high-margin business right now. We do expect, once it's in our fold, to be around 60% operating margins. So it's going to be one of the few acquisitions you could do that are immediately accretive to top and bottom line performance. You had one other part in...
Puneet Souda
analystYes, in terms of the pipelines and where it is right now commercially baked in into the products.
Kim Kelderman
executiveYes. So the pipeline looks really, really healthy. So we look at all the clinical studies going on in the fields, in the cell and gene therapy field or cell therapy fields, really. And we are sitting in almost half, so it would be 45% of all the clinical studies globally. So that means there's great adoption, right? And there are 7 approved therapies. And the last 3 were based on the GRx. So the adoption is very, very strong. And this morning, we had one more press release talking about specific funds and/or benefits for customers, specifically in academic, to also start using this GRx more so that we can even boost the [ B ] funnel, if you will.
Puneet Souda
analystGot it. I want to touch on, before we run out of time, on the spatial side. There's a lot of discussion there. There was an acquisition recently. Maybe just tell us, given the make of the market, how are you situated with Lunaphore? Where do you think it has the most value proposition? Where do you think you can take share?
Kim Kelderman
executiveYes. Thank you. Well, first off, I think seeing all the activity levels, investment levels, bigger companies coming in, is a complement to the end market, right? For long periods, people didn't think that spatial on tissue was going to be a thing. I think that's now behind us. Everybody agrees. It's a large, fast-growing market. Basically, it's segmented in 3 aspects or if it comes to the life cycle of a project. So people start with the research discovery phase, where the 10X platform as well as the NanoSeq, the now [ Brooker ] platform, are really, really effective where you can look at hundreds, if not thousands, of markers. And then once you know which marker you're really interested in or which markers you're interested in, and it's anywhere between one and 20 or -- and you can go up to 50, whichever you prefer, then you need higher sample rates. You need to be able to repeat your experiment. You need to have high sensitivity. And this is where our solution comes in, and that's kind of a triangle solution because we have acquired Lunaphore. So that gives you an automated instrument, which can run 4 samples in parallel overnight. So it is fully automated, so you can run 4x. If you work 5 days, you can run 20 slides, which is significantly more throughput than any competitor. And you can run antibodies through it to look at proteins as well as you can look at RNA, right? And for the RNA portfolio, we have 50,000 RNAscope probes, right, from ACD, which you know so well. It's been in market for more than 10 years, and it's the largest reagent business with a run rate of around $120 million. And then for the -- to look at your proteins, you would need antibodies. And the nice thing on this instrument, the Lunaphore COMET, is that you can basically use the antibodies you've already been used to. So you have data out of them and you don't have to swap, which is a real value proposition. But another value proposition is that we happen to have 400,000 antibodies, and we're actively validating these antibodies to be used on this COMET instrument. So we feel we have that market nicely triangulated. And if you think the last phase of a journey or a project would be to be a clinical assay. And even there, we have proven that we have brought some of our ACD reagents into the clinic with the HPV and HPV assays and some other assays. So we've also, again, exercised this QA/RA muscle so that basically, the customers can stay with us all the way through into the clinic. You might want to swap your [ box ] to a Leica or a Ventana machine because they have [ 30-sample ] throughput. And -- but there is a continuum, which is a very nice strength for us and that we really focused on building out over the last 5 years.
Puneet Souda
analystAnd you had validated your antibodies on other immunoassay platforms before, so it's a similar approach that you're using here too.
Kim Kelderman
executiveExactly.
Puneet Souda
analystOkay. Got it. And one question, maybe just -- I know this is more of a Jim question. But when you look at the margin levers, just how much of this is really dependent on just growth returning back on the top line versus other levers that you have in place?
Kim Kelderman
executiveFortunately, Jim isn't here but he's also educated me really well in how that all works. So operating margin is important for all of us. We were, last quarter, arguably under limited growth still at 33% operating margin level, right? Of that, there's a 230 basis point headwind from Lunaphore, right, and we're investing in it. We think this is -- as I just mentioned, spatial is a hot market, so we're not holding back to enter that market with the COMET instrument. And that put some pressure on our margins, which is fine because we think it's a good investment. And you take that out though, you would already sit at a 35-plus percent level, and we always think about being between 30% and 40%, right? So we can relatively easy, when the volumes come back, get higher and higher and touch the 40%. Maybe even past the 40% margins. But then again, it would be silly because you also want to, now and then, do an acquisition that would be accretive to the portfolio and would stick with the formula, where you have those 4 growth verticals that pull through our core reagents, which is the set-up you've come -- you're used to hear me talk about. And we want to continue that strength at engine really to fund those growth verticals that benefit from the core reagents. And yes, I think that there are acquisitions that we would add to the vault and then try to stay between the 30% and 40%. It wouldn't take a whole lot for us to be north of 35%.
Puneet Souda
analystGot it. That's great. Let me just have a quick rapid question here from an investor around the Asuragen acquisition that you did. We're hearing from NIPT companies about ACOG potentially benefiting them. Do you think that could be a volume driver if it comes through?
Kim Kelderman
executiveAbsolutely. I mean there are several organizations that kind of vouch for genetic testing and talk about which genes are relevant, and that's right up our wheelhouse. So I think as you know, the Asuragen acquisition has been a very, very good one. We wanted to combine the exosome capabilities with the laboratory channel and the laboratory products that Asuragen sells. The -- we are about to launch in this summer a broader panel influenced by some of the different authorities there but also influenced by the laboratory, our customers. So at the moment, they run some of these genes that are in, for example, the ACOG panel that are hard for NGS to do. Our solutions have always been very good at helping out the efficiency and do a qPCR or a CE and/or CE method to then still get through really hard to read genes. And there, we have a very efficient solution for genetic testing. So yes, we will -- we, of course, look at that, and we will have benefit from that.
Puneet Souda
analystOkay. Well, we're out of time with that question. But thank you again, Kim, for being here. Always fun to host you.
Kim Kelderman
executiveAbsolutely, my pleasure. Okay. Thanks.
Puneet Souda
analystThank you.
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