Ionis Pharmaceuticals, Inc. (IONS) Earnings Call Transcript & Summary

August 27, 2020

NASDAQ US Health Care Biotechnology special 50 min

Earnings Call Speaker Segments

Max Moore;Executive Director of Manufacturing and Operations

executive
#1

[Presentation] Good afternoon. My name is Max Moore. I'm Executive Director of Manufacturing and Operations here at Ionis Pharmaceuticals.

Kristina Lemonidis

executive
#2

And my name is Kristina Bowyer, Vice President of Patient Center, Direct Development.

Max Moore;Executive Director of Manufacturing and Operations

executive
#3

And we'll be your hosts here at today's Surf Away SMA event. Before we get started, a little housekeeping. This event is being recorded. We'll provide links at the end. In addition to those of you that signed up, we'll be providing you links via e-mail.

Kristina Lemonidis

executive
#4

Sure. And today, you'll be hearing from our executive team, from some of the scientists and from patients themselves.

Max Moore;Executive Director of Manufacturing and Operations

executive
#5

We'll also have some great music from Ryan Hiller. And of course, lots of surfing, my favorite. And we'll also get a special guest appearance from Surf Dog Ricochet.

Kristina Lemonidis

executive
#6

Hey, maybe, Max, we can start off with you talking about how this whole event came and began.

Max Moore;Executive Director of Manufacturing and Operations

executive
#7

Yes. That's an interesting story. It actually started with a social media post. Surf Dog Ricochet was at an adaptive surf meet at La Jolla Shores and had a chance encounter with a little boy named [ Aaron ]. He was SMA Type 1. And Ricochet's owner, Judy, posted that on Facebook, and I've worked with Judy for many years on adaptive surfing. And so I was friends with her on Facebook. And I saw the post and I reached out to Judy, and I said, "Tell me a little bit about this encounter." And through the discussion back and forth, I said, "Would you put me in touch with his parents?" And she did. And I exchanged some e-mails with [ Aaron ]'s mom, [ Mary ]. And through those exchanges, she provided me a picture of [ Aaron ]. And I printed it out right away and put it above my desk where it still hangs today. And it really didn't do anything for about 2 years, other than to say, every day when I came into my office, there was [ Aaron ] looking at me. And I always thought [ Aaron ] could be my own kid. And spring forward 2 years after I get that -- the photo, and I'm thinking about how to develop a team to emphasize with [ my department ]. And one day, I come into my office, it's all on my mind and I look up and there's [ Aaron ] staring at me like he does every day. And I -- kind of this light bulb goes off in my head. And I think let's marry these 2 things. I was thinking of doing this adaptive surfing, I wanted to do team building, and we want to reach out to our community. And so I immediately go into my supervisor's office. And I think he's going to think this guy's crazy, and I said, "Hey, I have this idea. I want to do this surfer thing." And he says, "Yes." Well, not only, yes, "Well, what else can I do -- what can I do for you?" And then, of course, once I got the okay, I immediately reached out to you. And you said yes. And then I called Surf Dog, Ricochet's owner Judy, and she said she didn't even get the yes out. It's basically, don't bother me, just tell me when and where to be. And it was just this tidal wave of yeses, people saying yes. As a matter of fact, I think after I got off the phone with you, you called Cure SMA.

Kristina Lemonidis

executive
#8

I did. I called Kenneth Hobby, President of Cure SMA, and they were on board immediately. So maybe you could take a second and kind of talk about how you've seen the event evolve since then.

Max Moore;Executive Director of Manufacturing and Operations

executive
#9

You know what, I wouldn't use the word -- instead of evolution, I want to think about progression. And what I love the most about this event are 2 things. First, I love seeing SMA athletes, surfers, progress. Each year, they push themselves a little bit harder and a little more adventurous. And it's just wonderful to see that progression. And the other thing that I think of is we've gone from the first day -- the first time we did this event, I was nervous. I didn't know if the SMA community would be receptive, who would be there, but it's almost from that day, it's almost like a family reunion. And those are the 2 things I think about when I think about evolution and progression of this event.

Kristina Lemonidis

executive
#10

It has. It's become a place where -- it's become a community event now. We have families picnicking. We've expanded to carnival games. I mean the event has really taken a life on its own.

Max Moore;Executive Director of Manufacturing and Operations

executive
#11

Yes, it really is. Like you said, it's just like a family reunion. So we're now in the sixth year of the Surf Away event. But you've been at Ionis for 28 years. And you've built an entire department from the ground up, Patient Advocacy. Can you tell us a little bit about that journey, and how it's influenced Ionis?

Kristina Lemonidis

executive
#12

Sure. I mean, for me, it's really been an opportunity to incorporate the patient perspective and bridge the gap between what patients are actually experiencing in their lives and the science that we're doing here at Ionis and really kind of integrating those 2 worlds together into creating exciting development programs going forward for our diseases.

Max Moore;Executive Director of Manufacturing and Operations

executive
#13

And at some point in this journey, you went back. And while you were working at Ionis, got your nursing degree. Can you tell us a little bit about that decision to go back and getting your nursing degree and how that's further influenced your department?

Kristina Lemonidis

executive
#14

Yes. I think understanding what a patient is going through is one component of it. And you really don't -- you only get that from the patient themselves because they're the expert in their disease. But you also need to understand how they -- how to treat a patient, right? It will be different by head count here as a physician or something like that. I think really understanding and learning what patient -- what field patients need to get a new perspective and really help me bridge that -- make that connection to the programs that we have.

Max Moore;Executive Director of Manufacturing and Operations

executive
#15

Yes. I really love that story. And up next, we're going to hear from Brett Monia, our CEO; and Frank Bennett, our CSO.

Brett Monia

executive
#16

Hello there. My name is Brett Monia. I'm the Chief Executive Officer of Ionis Pharmaceuticals. And I want to welcome all of you to this year's Surf Away SMA event. At Ionis Pharmaceuticals, we are committed to deliver transformational medicines to patients in great need, who are suffering from diseases where there's inadequate treatments available today. And we deliver this by producing medicines that are real breakthroughs, like we did for spinal muscular atrophy through SPINRAZA, the first ever medicine approved for the treatment of SMA. And we want to do this, and our vision is to do this over and over and over again for all kinds of diseases where there's great unmet medical need. And to achieve our vision, we work around the clock to find treatments for patients for terrible diseases. And that's part of the strategy to achieve our vision. Another part of the strategy is to get to know the patients, to reach out to the patient community. Because by knowing the patients, knowing the patient families and the community, it helps us deliver the very best medicines. And it's also very inspirational and motivational for the people here at Ionis. This is one reason why we very much look forward to the Surf Away SMA event every year. It's an event that started right here at Ionis Pharmaceuticals through one of our employees, Max Moore, and it's an event that has built and grown and grown over the years. This year, due to the pandemic, of course, the meeting is being held remotely. No pandemic is going to prevent us from having the event. But this year, it is remote. And I think you'll enjoy it, nevertheless. Next year, we do hope to have the meeting in person again, conditions permitting. We look forward to finding and seeing all of our friends in the SMA community again. So with that, enjoy the event, and hope to see you soon.

C. Bennett

executive
#17

Hi. My name is Frank Bennett, and I'm Chief Scientific Officer of Ionis Pharmaceuticals. I'd like to send a welcome to the SMA community. We've been motivated to work on SMA for the past 15 years. And it's a disease that's near and dear to our heart. And it's a community that has inspired us to do whatever we can to find therapies that are going to be of benefit to SMA patients. The SMA community is near and dear to our hearts. Working on SMA, I've had the opportunity to meet many SMA patients. And they really -- being able to interact with the patients is really what drives us at Ionis. And seeing the joy of life and the children and adults with SMA has really inspired us to do what we do here at the company. I really enjoy seeing the surf event. It's just wonderful to see the families out on the beach, enjoying the sun, and the children being on surfboards and the joy that's in their face as they're surfing. And I think, especially, that they're actually being able to surf with Ricochet, which is a dog that surfs with the children. And just seeing the smile on their faces and the family's faces really brings joy to my life. One patient that's helped keep me connected to the SMA community is a patient that I first met at an SMA meeting. At the time, it was called Families of SMA, which is now called Cure SMA. And this is a young teenager girl who was just starting therapy on SPINRAZA. And the physician that was taking care of the girl wanted to introduce me to the girl as well as her family. And she wanted to show an anecdote of what the impact of the drug was on the patient. So this is a young lady who is in a wheelchair, and it's an athletic wheelchair. So it's a fairly light wheelchair, and she introduced me to the family and the girl, and she says, show them what you could do. And the young lady stood up out of the wheelchair, turned around and picked the wheelchair up and held it over her head, which is not something she's ever been able to do, and so it was emphasizing the potential benefit that the drug was having on her. That was early days, but that was very exciting to actually see that happen with that young lady. That young teenager has now turned into a young adult. She's attending college now. And for the past couple of summers, she's been doing an internship at Ionis, working with our Patient Advocacy Group. And it's been a true pleasure seeing her work at the company and the impact that the drug has had on her life and also the impact that she's had on the company. She's been a tremendous motivation for people at Ionis. And again, just emphasizing the impact that SMA communities had on the company.

Kristina Lemonidis

executive
#18

Today, we wanted to bring you something special. And throughout today's event, we're actually going to be featuring musical performances by Ryan Hiller, a local San Diego performer, who actually do their performance at the Belly Up.

Max Moore;Executive Director of Manufacturing and Operations

executive
#19

And what an iconic venue, the Belly Up. I can't tell you the number of times I've been surfing and rolled into that venue with salt crusted. And just talk about a memorable night. You really haven't experienced San Diego unless you've been to the Belly Up. Let's go in and take a look. [Presentation]

Max Moore;Executive Director of Manufacturing and Operations

executive
#20

We have an opportunity now to hear from some of the surfers that have participated in the past years' event. As a matter of fact, we'll hear from [ Lauren Gibbs ], who I believe worked for you a couple of summers. Is that correct?

Kristina Lemonidis

executive
#21

She did. She did. She actually -- I met her several years ago when she just graduated from high school. And she just graduated from her master's program just recently, but did 2 years of internship in a row. And has actually produced work that we're in the middle of trying to publish for myotonic dystrophy. So she did an amazing job.

Max Moore;Executive Director of Manufacturing and Operations

executive
#22

Yes. We're going to hear from[ John Cave ]. When you think of a positive person, think of [ John Cave]. He puts together his own fundraisers along with MDA. And there's like hundreds of people show up. It's like a party, people come together, he throws a big barbecue at the end. He does things like Fill the Boot for firefighters. I mean if you know [ John ], it's almost like on a weekly basis, he's doing something to help our entire community out. Just an amazing human being.

Kristina Lemonidis

executive
#23

He is. And then I think after that, we have [ Ben Lu ] on film. And he has been surfing with us for, I think, at least 3 years now, who I first met at Global Genes several years ago, has been to Ionis. He's a math genius. He came to the SMA walk that we did at San Diego. The first Cure SMA, SMA walk in San Diego with his chair decorated full of army fighters against SMA. So it was actually a pretty -- he's a pretty lively surfer.

Max Moore;Executive Director of Manufacturing and Operations

executive
#24

Yes. I love Ben and really adventurous as well, right?

Kristina Lemonidis

executive
#25

Yes.

Max Moore;Executive Director of Manufacturing and Operations

executive
#26

And we're also get to hear from [ Bailey and Riley ].

Kristina Lemonidis

executive
#27

Yes.

Max Moore;Executive Director of Manufacturing and Operations

executive
#28

And they're really special. When you think about this surf event, you probably think, Ionis, adaptive surfing, Ricochet, they put all this together, but we were talking about -- we talked about progression. And this is really a marriage between the adaptive surfing team and the community. So the reason I tell you that story is when you see that chair in the water, with kids, with neck support or you see them on a respirator, the idea actually came from [ Riley ] and [ Bailey ]'s parents. They came up to us and said, "Hey, can you strap this onto a surfboard?" And we did, and that's still the process we use today.

Kristina Lemonidis

executive
#29

Absolutely. Haven't they actually come to visit? I think they --[ Riley ] and [ Bailey ] came to visit before?

Max Moore;Executive Director of Manufacturing and Operations

executive
#30

Yes, Riley and Bailey came down to visit, kind of one of the most memorable points in my entire career here at Ionis. Their dad had driven down from Orange County, and he did quite a bit of a drive for them, so he had to use the restroom. So when he did that, he wheeled the girls into this kind of small corridor, so we were close to one another. And he said, "Hey, can you watch them while I go to the bathroom?" And I said, "Sure." And when he did that, we were all alone, and it was real quiet and [ Riley ] looks up at me. And she goes -- and she says it just like this. She goes, "Hey. Hey. What's your name again?" I'm like, "My name's Max." And she said, "Can I sing you a song?" I said, "Of course." And she starts singing Amazing Grace. And I look over at [ Bailey ], and she's got this giant smile on her face, and I just broke down and cried.

Kristina Lemonidis

executive
#31

But that's what it's all about, right? It's inspiration like that, that really keeps us going into the drive behind everything we do every day here.

Max Moore;Executive Director of Manufacturing and Operations

executive
#32

Yes. It makes it real feel like family, when we're doing -- having those interactions.

Kristina Lemonidis

executive
#33

Absolutely.

Unknown Attendee

attendee
#34

Hi, all. I hope everyone is staying safe and healthy during these crazy times. For the past few summers, I've had the pleasure of helping to organize Surf Away at SMA. While I'm sad that we can't be together at La Jolla Shores this summer, I'm so grateful for Ionis for hosting this amazing event. I've loved getting to meet so many SoCal SMA families and friends. And it was incredible seeing so many SMA kids and adults getting to experience the beach last year with the power beach wheelchairs. I'm looking forward until we can be together again next summer.

Unknown Attendee

attendee
#35

Hi. I'm [ Ben ]. I have many fond memories of the Surf Away SMA event. Surfing had always been something only normal people did, not people like me with SMA. But thanks to Ionis, I too was able to enjoy the thrill of surfing. I have always been rather afraid of water. I was really skeptical about whether this whole surfing thing could actually work. But the volunteers assured me that it was very safe, even going so far as to customize my seating. So I gave surfing a shot. They hoisted me high above the sea, and then I was soaring over the water. It was unbelievable, an experience like no other. I ended up going back over the ocean 6 more times, more than anyone else. A sincere thank you to all the volunteers from Ionis that made Surf Away SMA possible.

Unknown Attendee

attendee
#36

Hi, everyone. Welcome to SMA Surf Day 2020. My name is [ John Cave ]. I want all of you to know why surf day is important to me. I hadn't been in the water for over 25 years. But growing up in Orange County, close to the beach, I used to go to the beach a lot in the summertime. So my first time back in the water was -- it was really special to me. My first time joining to surf day it was in 2017. I went into the water with a lot of kids and adults who have SMA, and feeling the water splashing against my body, it was amazing. It was the best feeling that I've had in years. But sometimes, it's just the little things in life that are huge. I'm going to miss seeing Surf Dog Ricochet. Ricochet plays a big part on surf day and surfing with the kids. Let's all enjoy SMA Surf Day 2020. Today, I'm looking forward to seeing you all next summer at SMA Surf Day 2021. Everyone, have a great time today.

Unknown Attendee

attendee
#37

Hi. My name is [ Miles McIntosh ]. Last year, I went surfing. I had so much fun. My favorite part was when I went on waves.

Unknown Attendee

attendee
#38

What do you -- what's a favorite memory of the surf day? How many years have you guys been doing it? Like, maybe 5 or 6?

Unknown Attendee

attendee
#39

I would say since Bailey was 3.

Unknown Attendee

attendee
#40

Well, I think it's before then. But anyway, so what's your favorite memory?

Unknown Attendee

attendee
#41

I like chasing the seagulls.

Unknown Attendee

attendee
#42

Chasing the seagulls?

Unknown Attendee

attendee
#43

Yes.

Unknown Attendee

attendee
#44

Okay. Anything about surfing? Have you always had fun surfing?

Unknown Attendee

attendee
#45

Yes.

Unknown Attendee

attendee
#46

And then last year, what you had said, "I want to go again. I want to go 7 times." Because?

Unknown Attendee

attendee
#47

I'm 7.

Unknown Attendee

attendee
#48

Because I'm 7.

Unknown Attendee

attendee
#49

Well, I was 7 at that time but now I'm 8.

Unknown Attendee

attendee
#50

So maybe next year, you can go 9 times.

Unknown Attendee

attendee
#51

Yes, I know.

Unknown Attendee

attendee
#52

What do you think, [ Bailey ], do you like surf day? You've always love surf day. I think some of your favorite memories are -- so every time you're out there, you like also getting lifted by the men and women that help out, right?

Unknown Attendee

attendee
#53

Yes, I like that.

Unknown Attendee

attendee
#54

You like that too? Do you feel like a princess?

Unknown Attendee

attendee
#55

Yes. I always feel like I'm the queen.

Unknown Attendee

attendee
#56

The queen bee.

Kristina Lemonidis

executive
#57

I'm sure you're wondering about safety. I think maybe, Max, you could talk a little bit about what goes into planning an event like today.

Max Moore;Executive Director of Manufacturing and Operations

executive
#58

Yes. You know what, some of the things we've talked about, it's been a lot of progression. The first year, we hosted the event, we used professional surfers and folks like myself with decades of experience with adaptive surfing. And we really relied on Surf Dog Ricochet's group that came in and helped us out. And talking about people with decades of experience with, certainly, people with spinal cord injuries, brain injuries, mental disorders, rare diseases. But we've really transitioned from there, real formal, we have a rigorous training now. It includes logistical planning, classroom training. We do coordination with the lifeguards at the beach. We even have a group that just thinks about the equipment safety. So a lot goes into it. You see a picture from the event, and it makes it appear like sometimes there's 1 or 2 people in the water with the SMA surfer. But in fact, there's nobody -- there's never less than 17 people to support each surfer. So sometimes you'll see we'll have 2 boards in the water. There'll be 40 people helping out with 2 people surfing or 2 SMA surfers. So there's a lot goes into it, and we're really proud of our safety program.

Kristina Lemonidis

executive
#59

It's an amazing effort that goes into that.

Max Moore;Executive Director of Manufacturing and Operations

executive
#60

Yes.

Kristina Lemonidis

executive
#61

Our next guest is very, very special to us, and really doesn't need much of an introduction at all, but they've been a staple since day 1.

Max Moore;Executive Director of Manufacturing and Operations

executive
#62

Absolutely. Surf Dog Ricochet's owner, Judy. When you think about selfless human beings, and people have given to our event, given to our community and really given back to the world. I mean running events all over to help folks out. Think about Judy. I can't wait to hear from her.

Judy Fridono;Puppy Prodigies;Founder & Executive Director

attendee
#63

Ricochet actually was slated to be a service dog for someone with a disability, but she had too much interest in chasing critters. So one day at the beach, she jumped on the surfboard of a boy who's quadriplegic, and that's where it all started. And she's been surfing with people ever since. I first met Max way back, I think it was 2009 also, maybe 2010, early 2010, and I heard about another boy with a brain injury named [ Ian McFarland ]. And he used to surf with his dad. And unfortunately, his parents were killed in a car crash where he suffered a brain injury himself. And they had done a fundraiser to get [ Ian ] surfing again. They've put me in touch with Max. And we took [ Ian ] out to surf, and we've been surfing ever since. [ Ian ] was hesitant to get back in the water. It's a scary thing to go back in the water now that you're not 100%, and you have a brain injury. And certainly, he was in the water all the time with his dad. So he held that special place with his father. So going back in was a little intimidating. But once he heard that he can surf with Ricochet, he was excited. So the excitement kind of replaced the fear, and he went back out there, and he was empowered. So my favorite moment when we ask a child when they come back another year, and they've surfed once before with Ricochet or maybe twice. And we'll say, "Hey, you don't want to surf with Ricochet?" And they'll be like, "No." Because now they have more confidence and they want to do it by themselves. So to me, that means more than anything. And that's -- to see that growth and that confidence in them, that's what stands out for me.

Unknown Attendee

attendee
#64

He's a very ordinary dog with an extraordinary spirit. Ricochet is able to identify in people what they're missing and is able to provide it.

Unknown Attendee

attendee
#65

From birth, a golden retriever called Ricochet was in training to be a service dog to help those with disabilities lead more independent lives. Sometimes the size of her spirt or her boundless energy or her love of the water, could overwhelm her training. It was difficult for her to find the right balance as a companion, but balance would prove to be her special gift. She excelled on a board in the water. If she could not fulfill her mission in a traditional sense, she was about to find another way to serve. It began in August 2009 with a quadriplegic teenager named [ Patrick ].

Unknown Attendee

attendee
#66

The original idea was we were going to surf next to each other. And then at the end of one of the waves, like we stop at the beach, and [ Ricky ] jumps off her board and then jumps on to my board.

Unknown Attendee

attendee
#67

It was like they had been surfing together forever. And at that moment, I realized this is what Ricochet is here to do.

Unknown Attendee

attendee
#68

Somehow, Ricochet knew instinctively how to use her weight to counterbalance the board for special needs surfers. It worked. And when Judy posted scenes of Ricochet on YouTube, the video drew hits in the millions. The wave was building, and others got on board. For the dog that had too much spirit, there was another way to serve and a new place to help. The proof is in the joy and spray, the laughter in the water. Her spirit is in the surf and the wave rolls on. [Presentation]

Max Moore;Executive Director of Manufacturing and Operations

executive
#69

Another amazing song from Ryan, Ride that Wave, how appropriate. We've spent the years just enjoying so much support from Cure SMA.

Kristina Lemonidis

executive
#70

We have. We've worked with Cure SMA since the very beginning, even since before I even started out the program. And they have been huge supporters. And I remember their interest, he's just excited about us getting to get the community out on the beach. And yes, of course, everybody would to be interested. So we have a great opportunity to hear a few words from them as well.

Max Moore;Executive Director of Manufacturing and Operations

executive
#71

All right. Let's hear from them.

Unknown Attendee

attendee
#72

On behalf of Cure SMA, I wanted to say a special thank you to Ionis Pharmaceuticals for putting on the Surf Away SMA event once again this year. And it's really special for us to see this event, which sends a really good message to our community and beyond on what is possible for people in the SMA community. It's very special for us to see this event still going on with everything that's happening with the current pandemic. And we're very excited to see this happening. It really is a message of the progress that we're making in SMA, the barriers that we're pulling down, allowing things for our patients to be possible that never were in the past. And a lot of this as well is thanks to Ionis and what they've done on the research front. Ionis is the company that actually did all of the early research and the clinical trials that led to the first ever treatment getting approved for SMA. And this is a treatment now which is making such an impact in individual patient's lives, families' lives, just around the world as well, where we actually have about 10,000 patients now who are on that treatment. And so we're seeing these changes happening in our community, these barriers coming down, showing what's possible for members of our community, much like what the Surf Away SMA event actually does. And this is thanks to getting that first treatment approved. And something special, I think, right now is just a few weeks back, we actually had California come online and implement newborn screening for every infant that's born, they will be screened now for SMA, and that's thanks to getting a first treatment approved there. And so where this event, the surf event is being carried out, now in California, all newborns are getting screened. So that's a really exciting development for us. So once again, I wanted to say thank you Ionis for all that they've done, bringing these barriers down, showing us what's really going to be possible for members of the SMA community in the future. Thank you. [Presentation]

Max Moore;Executive Director of Manufacturing and Operations

executive
#73

I really love that song, Push A Little Harder. It not only describes what we're trying to do in the surf, I mean the progression every year, pushing ourselves, pushing our SMA athletes. But I think it really describes our scientists here at Ionis very well. I mean a lot of them like to work 24/7, and they're definitely always pushing themselves.

Kristina Lemonidis

executive
#74

They do. They do. We actually have an opportunity here for Frank Rigo, who was part of the lab back in the day, and he's sharing a moment about one of the big breakthroughs that we had for SPINRAZA before it was even approved, as well as a few other employees that have -- wanted to share a few of their thoughts about what a special event this is to them every year.

Frank Rigo

executive
#75

In a moment, we are -- we have high aspirations, and we want to do great things for patients. But if you just work hard and you don't appreciate the magnitude of the time of what is going to happen in the future. For me, a very important moment -- and I haven't shared this with a lot of people at the company, but very early on in our Phase I, a few patients were too late in their disease and unfortunately, they passed. But their families were gracious enough to give their tissues -- their CNS tissues up for analysis so that we can analyze the levels of drugs and look at whether splicing was modulated. And luckily, at the time, we had a collaboration with Charlotte Sumner, who was doing autopsies to better understand the disease in patients, and we were able to collect from her a couple of samples from patients that have not been treated with the drug. So [ Michaela ] and I were basically running the gels and sort of looking for whether the drug actually modulate splicing and [ Michaela ] ran the gel and we were supposed to like take a look at it on Monday. But obviously, I came in on Saturday and had to take a look at the gel, and that was the most important moment in my career. I'm not sure I'm going to have a moment so intimate with the data like that where it was just me standing in front of the scanner. And this takes 5 minutes to scan the gel. And the top band that you see is the band that tells you that the drug is working. And that band was more intense as the scan was proceeding. But of course, you don't know if the top band is more intense until you look at the bottom band because the bottom band needs to be less intense. And it's just that, it was a roller coaster of 5 minutes where it was from very, very worried to like the happiest person in the world because I knew that the drug was actually doing what it was supposed to do. And at that moment, I knew that it had to work sooner or later.

Unknown Executive

executive
#76

Hello, everyone. How are you guys doing? Even though we're not able to come together at the beach this summer, Ionis community wants to celebrate the 2020 Surf Away, the SMA, with you in this very special way. Personally, I want to wish you and your family all the best. Stay safe. Don't forget your masks. And we can't wait to see you all at the beach soon. Bye.

Unknown Executive

executive
#77

Hey, guys. I hope you're doing well and you're staying safe. I hope I can see you guys soon. And hopefully, we can have Surf Away SMA very soon. One of the things that I really enjoy about the event is just spending time with you guys and being able to volunteer with my team at Ionis. And really seeing us make an impact and seeing it in first person really does mean so much to me. So hopefully, we can get together soon. And until then, stay safe. Bye.

Unknown Executive

executive
#78

Aloha, my SMA family. Sorry we can't meet in person this year. We miss you. We love you. I hope you enjoyed all the memories and clips from the previous years. And I hope next year, we could celebrate out in the water. We love you, we miss you and Aloha.

Unknown Executive

executive
#79

Hi, everyone. My name is Jordan Hedrick. I work in the development chemistry group at Ionis Pharmaceuticals. And I just wanted to come on here and say, hi, and record a little message, just letting you all know that we miss you. It is definitely not the same, not having the ocean this year for our Surf Away SMA event. But we do have each other, and I'm super excited that you are all here for our virtual event this year. I have met so many of you over the past few years. I have actually been volunteering with this event since the beginning. And I have been able to meet so many of you and get to know your stories and just enjoy your smiles and just be there to see life-changing events happen for all of you. And I'm just so thankful for those opportunities that we have. And we hope that you have fun at our event this year.

Unknown Executive

executive
#80

I remember the first year that we were running the SMA surf event. The theme was SMAsh SMA. So what we decided to do was build the sandcastles with wooden planks inside that the kids could use their wheelchairs to back the planks of wood out and destroy the sandcastles. And so we spent all day building these sandcastles, but we had no idea what we were doing. So the sandcastles kept falling apart as they dried out in the sun. So eventually, we kept refortifying the castles and we got them made. And apparently, we fortified them too much because we could not take down those sandcastles for the life of us. But we ended up just kind of steamrolling it and just kind of smashing the castles ourselves, and it was really fun.

Unknown Executive

executive
#81

Hi, everybody. My name is [ Jamie Dacosta ], and I've been participating in the SMA beach day for the last 4 years. I'm really excited that I get to see these patients use our novel therapies that we developed at Ionis. And my favorite part of the beach day is when these little kids get to go surfing with the dog and play in the sand. Everybody's nothing but laughing and smiles. Can't wait to do it again.

Unknown Executive

executive
#82

Hey, guys, [ Aaron Holder ] here. Wanted to reach out with the Surf Away SMA event. I know that this would happen to be online, it's not ideal. I got the video up running in the background. I figured that might be nice to at least see some waves. Everyone wants to share some fond memories that we had. I was -- been able to join in, what, 3 of these events, I think, up until now. And every year, it's just been awesome. And I mean the smiles that it brings to everyone's faces, the water gun fights that we get to have, the balloon tosses. I've personally been involved every time with [ John Cave ] and taking him out and getting to get him back in the water has always been some that I've enjoyed. I know Max and I and a few others even took a Saturday and we were able to get them out there, even further into the water than we were at the normal events because we're able to dedicate a little bit more time, and specifically try to craft a board that would really, really let us give them the overall experience that we were looking for. So that's just some of my fond memories. I really am bummed that we're not going to be able to do it this year, but I'm sure that next year, everything will be cleared up and we'll be able to get back out there and have another great day. So keep surfing, have a good time. We'll catch you soon. Bye.

Unknown Executive

executive
#83

What I love most about the Surf Away SMA event is playing with the kids and spending time talking with the families.

Unknown Executive

executive
#84

Hey, everybody. Sorry we didn't get a chance to do the event this year. I've had a blast every year getting to know you guys and getting out there in the water with you. You're really inspiring, and hope to see you guys next year.

Unknown Executive

executive
#85

Hey, guys. We have a lot of fun with you every year, going out and surfing, and we're going to take his time and just enjoy the summer and get healthy and get safe, so that next year we can be out there in the water, enjoying the surfing with you.

Unknown Executive

executive
#86

Hey, this is [ Jenny ]. I'm here with [ Jeremy ] and were just reminiscing about all the times that we've come down to this beach for the SMA surf event.

Unknown Executive

executive
#87

We have so many fond memories the last time we've done it. The first time we did it, there were only a couple of people out here, and it's grown so much. It's been so incredibly special to be a part of it. And we do miss having everybody out.

Unknown Executive

executive
#88

Yes. I remember being so inspired that first year. I was so excited to see everyone in the water and we can't wait to see everyone in the water again.

Unknown Executive

executive
#89

Surf's up, guys.

Unknown Executive

executive
#90

Yes. Bye.

Kristina Lemonidis

executive
#91

Thank you all so much for tuning in today and really being part in making this virtual Surf Away SMA event a success for us. I hope you know how very near and dear to our hearts you all are and how much we would have rather been on the beach today with everybody enjoying the sun and the sand between our toes. But with this environment, this is just one example of how we're looking to involve some of the community efforts that we're taking forward. So we're looking at other wellness programs that we could do virtually as well. So hopefully, this -- you'll find this is a success. And...

Max Moore;Executive Director of Manufacturing and Operations

executive
#92

Yes. A great example of that is at the end of this session, we have a video from Adapt. It's a self-guided meditation. As you mentioned, these are really stressful times. So at least for me, I find that meditation and a little time alone is so important. So hopefully, so you can access that. To play off what you were saying, I really can't say how much we appreciate your participation over the year and sharing yourselves and sharing with family. We miss you. We'd much rather be at the beach. With that being said, why don't we leave this event with a powerful song from Ryan, Rise Up.

Kristina Lemonidis

executive
#93

Thank you.

Max Moore;Executive Director of Manufacturing and Operations

executive
#94

Thank you. [Presentation]

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