MindWalk Holdings Corp. (HYFT) Earnings Call Transcript & Summary
July 19, 2023
Earnings Call Speaker Segments
Martin Gagel
analystAll right. Just some preliminary comments here, everyone. Thank you, firstly, for joining us. Jennifer will be presenting and discussing the business. I'll be asking some questions, and we're digging into it a bit. And then at the end, we are taking questions from the audience. We have received many questions already. We will go through those first. And then we will go through the questions that the audience puts in there probably at the bottom of your screen there is a Q&A button type in your questions. We've addressed it, we'll skip over it, and we'll try to get through to everyone. And then with that, I'm now going to start the official presentation, Jennifer, are we good? all right. And here we go. Good day. We've got CEO, Jennifer Bath, of ImmunoPrecise Antibodies joining us today. ImmunoPrecise is an antibody development company using biology, modeling and artificial intelligence. It's Wednesday, July 19, and I'm Martin Gagel with Market Radius Research. Please remember this is neither a recommendation nor investment advice, we're here to learn about the company. Jennifer, thank you very much for joining us. We've got a big and excited audience online with us. I am new to the ImmunoPrecise story. So for myself and others new to the story, Jennifer is going to give an overview of the company and the opportunities, and then we'll dig into the details and take questions from the audience. So Jennifer, again, thank you very much for joining us. Please introduce yourself and tell us a bit about ImmunoPrecise.
Jennifer Bath
executiveWonderful. Well, thank you, Martin, and hello, everyone. My name is Jennifer Bath and I am the CEO of ImmunoPrecise Antibodies, also known as IPA for short. We are a publicly traded company on the NASDAQ Global Market under the ticker IPA. And at IPA, we bring about 30 years of innovative antibody technologies and platform development, together with patented AI-driven technologies used to identify meaningful patterns that provide unique insights into biology, disease and medicine. We are reshaping computational systems biology and setting the stage for a future where AI is a predictive force in antibody discovery and development, driving novel insights using multimodal analysis within a single framework. In other words, collecting insights and identifying hypotheses by analyzing all different types of data in one single place. I'll share on this webinar areas in which LENSai technologies from our subsidiary, BioStrand are shaping this transformation in drug discovery and in analytics and explore the potential of our patented technology. So before we dive into the details, as always, I would just like to establish that any forward-looking statements made during the presentation are based on our best knowledge and our current understanding at this moment in time, it's really important to keep in mind, of course, that they should not be used as the sole basis for investment decisions without conducting your own research. All right. So advancements in science have really ushered off into this era where we are just steadily decoding really what is a complex language of biology. This capability grants us the ability to understand life's intricate details at actually a molecular level. And this is -- it's not a futuristic vision, it's actually something that we're able to do here and now, and much of this is made tangible by the work at IPA subsidiary, BioStrand. So this innovative blend of artificial intelligence and then biology is really beginning to revolutionize the field of computational systems biology. It's also paving new route for a therapeutic antibody discovery and development as well as data organization and data analysis. IPA really stands at the forefront of this progress driving major advances in technology. Throughout this webinar, we're going to delve into some of the inner workings of our unique capabilities, and we're going to provide you with substantiated evidence of the novelty of our capabilities and offerings and then there are potentially transformative impact on the development of novel therapy. So you're probably all aware of the fact that the world has just in abundant and diversity of just biological data, including genomic data, proteomic data and any other type of omic data that is out there. And this wealth of information has the potential to unlock a very deep understanding of life and of diseases and disease processes. However, here's the catch, this data oftentimes exists in isolation, and it's scattered across various different data sets. For instance, like in the scientific landscape, we're experiencing exponential growth in biological data. It's like just a never-ending stream of information that's coming at us. And each data set is created by different researchers and different institutions that ends up getting stored in different formats. It gets locked away in separate silos. And it's like trying to solve a puzzle when all of the pieces of the puzzle are scattered across different rooms. So the fragmentation is actually what ends up causing a huge challenge for researchers that want to collectively use and analyze this mass data. So to illustrate even within a single modality such as just text, the data can be stored in different silos. For instance, you might come across an abstract of a research paper PubMed but the access to the full article, you need to actually go and dig through a different source. It's like chasing after puzzle pieces that have been hidden in various places or better yet like trying to actually write a sentence in 5 different languages, it just does not work to bring this all together. And it doesn't end there, even if we look at like a single dimension. So if we just look at, for instance, like structural data, there are different formats and different ways to describe those structural formats. So even analyzing like data from a single modality becomes a really challenging task. It's like trying to make sense of the jigsaw puzzle when everyone uses different colors and shapes for their pieces. So this fragmentation is what we call the Information Integration Dilemma or IID for short. It's the challenge of bringing all of these scattered pieces of data together to form the complete picture. Without being able to integrate those data sets, we miss out on really valuable insights that could be gained by combining them. So again, back to my analogy, it's like looking at individual puzzle pieces without actually ever putting them together and seeing the whole picture that they create. So in today's discussion, what I'd like to do is delve into how we're tackling this challenge and how we're using our solution to actually solve problems. We'll explore the ways that BioStrand has actually overcome the IID with the Information Integration Dilemma. And then we'll show you how we've used this to unlock the true potential of data. So I want to start off with just some of the basic terminology to make sure that it's easy and clear to follow. So the terms dimension and modalities are key to understanding our work at BioStrand. So to illustrate, consider like Meta AI's recent announcement that they've developed a framework that can integrate text and image. Here, the text and the images represent two different modalities within a single framework. And that's fascinating yet the complex part of our field of biology is that we handle at least 3 different types of data: unstructured information, so things like the research papers would be an example; sequential data, so just reading through genetic code or other sequences; and structural data like the 3D molecules. The challenge that we face is about figuring out how to merge all of these different types of information from the text, from papers, genetic sequences, 3D molecular models into a single system to effectively extract meaningful information from that. So as I alluded to, BioStrand has solved this problem, which I just referred to as the IID. Lacking this ability historically, people have always chosen instead to focus on a single dimension or a single modality such as a natural language processing to harness all of the data in scientific information or focusing on, for instance, structural information such as AlphaFold does. However, until now there hasn't been an integrated framework where all of these modalities could be combined for analysis. So BioStrand has solved this issue. We've eliminated the need to choose between different modalities. We bridge these different dimensions and modalities with the aim of integrating, consolidating and then analyzing them using state-of-the-art AI algorithms and technology to gain those novel insights. So one interesting fact that I always come back to is when we tell experts that we're combining tech and fintech and structure, they recognize the enormity of this challenge. We're addressing the issue with our integrated intelligence platform which is based on a technology called a HYFT technology. And this unique approach brings together all of these different dimensions, and it effectively positions us at the forefront of health care innovation particularly in the exploration and discovery of scalable integration across these different modalities. So what I'd like to do now is just introduce you to these proprietary HYFT and what they're exactly about and how they help us accomplish this. So our unique and patented HYFT, also referred to as universal fingerprint. They provide the key that allows us to integrate and merge these various types of information and dimensions. We utilize the HYFTs to create a single, enormous knowledge graph. And with this graph in place, we can apply advanced AI, and we can apply deep learning technologies to assist experts in their decision-making process. We include these deep learning models based on statistics within our framework, and then we marry them with rule-based or straightforward inquiries for data analysis. As a result, our approach combines different strategy, applying a hybrid approach. The volume of data that we're dealing with is enormous and it's growing, and it makes scalability absolutely crucial in our field. Our HYFT-based model is extremely scalable, and it understands context at different levels. It can make predictions and they can distinguish between known information and what is actually new information. The core capability makes -- the core capability of HYFT is data integration. It integrates all of these different pillars within the biosphere. So sequence, structure, function, which is incredibly key and even text. So as such, we're able to integrate new information or models as they emerge in real time. This core capability allows us to actually stay ahead of competitors.
Martin Gagel
analystSo just -- so your -- initially, what you do is you collect data from various disparate sources and you put into a big data graph, a big database and then you've got AI tools to sort of extract or understand it. But that graph, can you sort of attach other AI tools or models to it? So essentially, your initial value is in collecting and putting it into a usable form and then it's available to yourself or to clients to when it's in sort of one giant database. So now they -- once it's in that graph, they've got lots of different tools to extract it from it. It's the assembly of the data that is key to this?
Jennifer Bath
executiveYes. So actually, there's a number of different ways to use it, and I love this question because we are creating proprietary databases using data that we're generating at IPA and in addition to that, the information that we have contained within our knowledge graph, which again is enormous. It has over 25 billion association within that knowledge graph is all based on information that has been collected and screened and also related back specifically to these HYFTs. And that information comes from all different sources. And again, it can be any type of data. But a lot of that is based on external databases that we're able to access and then also the internal information that we put in. And so when it comes to analyzing information for clients, we can do a number of different things. We can actually use client proprietary data which we don't store, we don't keep. They don't need to worry about us using that data later in order to analyze that data using our platform and extract insights that they wouldn't otherwise be able to see because as we push out into the LENSai and it analyzes all of this information from various databases and again, our own internal information, it's able to do so across any, again, any modality in that one single framework. So you're extracting these insights that, yes, that a client would never able to be able to collect in and to analyze and then you're getting these insights pertaining to what it is that they're researching. And yes, that knowledge graph connects all of this information. And as I'll talk about here today that HYFTs now enabled this to happen at almost an instantaneous speed and with very little energy because all of the information that actually gets input, not only is searching really all of these different modalities, but it's searching it through our patented HYFTs, which go out and find and extract the meaningful information only that come back to create this knowledge graph, which allows you to look at the connections, to identify how things are related. And also, really importantly, which I don't think we'll have time to get into today happens in a white box manner, which means you have complete traceability back to any of this information. If you're drawing a conclusion unlike, for instance, like Chat GPT and other generative AI algorithms, where it happens in a black box, you have no idea how they came to a conclusion. you have no idea if it's accurate. You can't track it back, you can't pull that as a research to validate its accuracy. We have done the exact opposite here. And so it's kind of multiple different components of what makes this really unique for that type of analysis.
Martin Gagel
analystAll right.
Jennifer Bath
executiveYes, it's really fun.
Martin Gagel
analystIt is.
Jennifer Bath
executiveAll right. So no -- so back to the HYFT-based technology, it's been compared, and I really like this comparison to a database [schema], really, that's generic enough to adapt to improvement in underlying technologies and then assure that we stay ahead. So as you mentioned, does it plug into other platforms? Can it be used with other platforms? Absolutely, it can and in part all of our unique capabilities to other platforms that they're connected. And our technology in and of itself is so scalable that it can handle the vast amounts of information out there in the biosphere. And then as I alluded to, it does it incredibly rapidly because of the HYFTs that are at the core of the software.
Martin Gagel
analystAre you using your own server farm? Or are you -- is this running on Amazon or Azure? Or how does the actual physical infrastructure work?
Jennifer Bath
executiveYes, so we do store information on -- we do store data on AWS. However, our proprietary HYFTs and our proprietary code is actually not actually connected to any accessible database, and it's not actually live connected to the internet is something that we briefly put in to extract what we need to need immediately and then unplug so from a safety perspective.
Martin Gagel
analystOkay.
Jennifer Bath
executiveYes. So I think a way to maybe also for -- because I realize some of this actually gets a little bit deeper into the complexity of data analytics. So a way to make it a little bit clearer sometimes is if we just take a look at the life of like an everyday researcher. So everyday researcher in the laboratory, whether it's an academic institution or a commercial company anywhere from small biotech to pharma. If they want to explore any certain type of disease, target, for instance, they need structural information, then they would need to go and access a very specific database for that. And if they need sequence information, then they'd have to switch to another tool. And if they want the latest inside, they would actually need to go yet again to another tool. This is actually how we did it 20 years ago when I was in graduate school, and it hasn't changed much. So that sounds a lot. And it's -- these are all separate tools and even for the most basic of research. And so this back and forth that ends up happening between databases and data types and different models is incredibly tight consuming. It slows down research at every stage. And that's what's unique about our LENSai software. Our platform is unique in that it can oversee all of the connections between these modalities right there in that single framework. So another way to look at our HYFTs is like they are -- they're like words and text. They provide meaning, they provide context and they provide ranking information. So also, if you think of basic generative AI programs, they're not able to do that. They can't tell you if a particular word is referring to a gene or a protein or what exactly its relationship is to the context around it. So like Google's PageRank, we can identify which patterns are more informative than other patterns. And this capability allows us to create massive amounts of data. We can eliminate background noise, and we can identify only what is most important for the research at hand. And we can capture all these relations from all of these different modalities using information that we can then go back and use to support wet lab discovery, which is an extremely important part of what we do at IPA as well. So we are now combining decades of scientific expertise in antibody discovery with the massive potential of AI. So our laboratory technologies, they are proven. They have successfully produced antibodies that have gone on to the clinic, supporting various pharma companies in reaching their goals. Our laboratory technologies have now been used for 19 out of the top 20 pharmaceutical companies and literally hundreds and hundreds of clients. And now we're taking that wealth of experience, and we're integrating it with our LENSai technology. And it's not just about gathering high-quality data, it's not -- this is just not the singular focus, we're making that data work smarter. So that's where our patented HYFTs really come into play with the wet lab. The HYFTs are unique integrators that facilitate a 2-way conversation between our lab and then the AI. And our lab provides the insights to the HYFTs and then return the HYFTs guide our laboratory research. And we refer to this as an active learning loop or sometimes you'll hear us refer it to it as HYFT enrichment, the HYFTs are constantly being enriched to better connect with each little pattern means with regard to structure and functional relationships. So if you imagine the exchange of insights between our LENSai software and biological systems, each new discovery adds depth to the previous ones, paves way for more precise and more efficient drug discovery and it's a synergy between knowledge and technology that just constantly is pushing the boundaries of what we're able to do. So our goal is driving the growth of our business by offering a compelling and also a very unique value proposition. Our cutting-edge and in silico technologies, combined with our award-winning wet lab expertise including our well-known function first B-cell platform, creates a powerful combination that revolutionizes how we interpret data, and that's really a key component. So there are a lot of different ways right now that we're using LENSai actively to solve various challenges for clients. We have two publicly released examples of recent real-world applications of LENSai and this platform, and how we begin to leverage our IID solution and the ultra-scalability within our software to solve complex challenges for clients. So these data provide early insights into the versatility of LENSai and they give you a glimpse into the impact that they can have on BioStrand's business, and even their early applications have already enabled the launch of unparalleled capabilities in our contract research and they've played a role in -- a very crucial role in advancing an active clinical trial. So I'll share these two examples of case studies with you. All right. So the first case study that I'm going to share with you is a little bit more in depth and a little bit more technical, but I'm going to break that down for you as you go and we've put a lot of detail in here because it's got these -- a lot of different components that are really at the core of our LENSai software, but also it's one that we're really feeling a reverberation in our market as we've put this out there over the last 3 months and clients begin to understand how it can really impact their programs in terms of speed and cost and in quality. So this case study here underscores really our initiative to transform what is known as the transgenic animal market with an integrated digital platform for what is known as humanization. And humanization is the process of taking an antibody and making it more human-like, so that the therapy doesn't have any unintended side effects when it's administered to a patient. So this service features our LENSai-driven immunogenicity workflow that has a very unique advantage over our competitors. It uses the scalability of LENSai to analyze the entire proteomes of multiple species, providing insights into what evolution declares is like human-in-nature versus nonhuman-in-nature. And it provides more thorough coverage of antibody sequences under analysis compared to competitors, which is really important because any slight change in a sequence can lead to an unintended negative clinical effect. So recent or rodent models, they have really always played a role in antibody discovery, and for these antibodies to be used safely in humans, they must either originate from these transgenic animals, because these transgenic animals have been genetically engineered to produce human antibodies. So they're human in nature already, so they're going to be safer or the antibodies need to come directly from a human or they originate from a natural animal, which has held the majority of therapies that have gone on successfully into commercialization have been discovered, where the antibody after it's discovered, it then goes through this process of what we call humanization and that process modifies the nonhuman antibody to make it safer for use in humans to make it look human, if you will. And so these transgenic animal models emerge to address what was an inefficient humanization process which included long time lines, really high cost and then also, probably more importantly, the risk that in going through the process of making that antibody human, you are actually going to lose the activity that made that molecule effective. So -- however, there is drawbacks also to the transgenic animals space. So compared to natural animals, these genetically engineered animals, they typically demonstrate a weaker immune response, and they typically have less diversity in the antibodies that they can produce, which means that overall, you're going to have fewer therapeutic candidates to choose from. And then also not to overlook that there's a lot of substantial costs associated with them. They may include royalties, licensing fees and milestone payments, and that's all being added on top of the millions of dollars of R&D expenses just to develop the drug. So IPA's new solution determines a proteins immunogenic potential by integrating artificial neural network-based binding predictions, to see if a region of an antibody is actually likely to bind to human sequences in the immune system that would indicate that, hey, that antibody, it's foreign, or that's potentially toxic, you shouldn't move forward with it. And our scalability within LENSai enables the comprehensive and very rapid identification of those dangerous antibody sequences. So our models predict that binding event and then in addition to that, it compares that to these flagged regions of the antibody to scan the entire human proteome and start pinpointing any stretches within that antibody that might be considered foreign and that might be considered dangerous. We've already calculated the immunogenicity scores of over 2,000 different antibodies. And we use that information to guide new discoveries and then improve also our method of humanization. So in this case study, if you look at the panel in the middle bottom of the screen, I see if I can point to it, right here, you can visualize also the clustering of 260 clinical antibodies that we benchmarked using our algorithms. And we segregated them based on their origin, and this also demonstrates the accuracy of our predictions that they sell into the right cell clusters with regard to origin and also with regard to clinical data that's available. However, probably the most important aspect of this workflow is the scalability and it's the rapid analysis that enables us to screen very early on in an antibody discovery program. So if a researcher is sitting there with thousands of antibodies early on in the research, which is oftentimes the case, and they need to make a decision on which ones to move forward we can very rapidly take LENSai, and we can use that to identify the antibodies that have the highest probable toxicity. We can remove those from the study very early on and then reduce the time and reduce the cost of going forward with further characterization. So it makes it easier to find the lead candidates of interest. And when that candidate is identified, we can then apply a very rapid humanization process, which is actually shown here now in the upper left-hand corner, where we utilize antibodies that, in this particular case, we went for ones that were extremely immunogenic, very toxic. They actually were identified from a chicken, which is incredibly different than a human antibody. And then we applied a very rapid humanization by making minimal changes to produce a safer version. And in this particular case, we started with one antibody pair, and so it's a heavy chain you see here at the top of this graph. These are -- antibodies are made up of 2 chains, a heavy chain and a light chain. We started with one parental heavy chain and one parental light chain and then what we did was we made minimal mutations to these, and then we rapidly identified the best therapeutic clones here. Four different versions, new versions of each of those that were the least immunogenic and the most human in nature. And in this particular study, we identified 2 different clones that you'll see boxed here in orange, H2 and then also L3 and then using data from another experiment, which you'll see here in the lower left-hand pocket here, we were able to actually demonstrate that we retained the desirable properties of the original parental clones. So in summary, we went through this process, we can go through this process of screening down all of these antibodies to find the best leads but when we get to the best leads, we can humanize them very rapidly. This analysis tells us, "Hey, these ones are the most human. These are the ones you should look to move forward, but did we retain the function? Remember, that's one of the biggest challenges in the process of humanization. And yes, we can demonstrate that we can also retain the function of these particular antibodies. So this process in and of itself is extremely rapid, it's extremely scalable, and it costs a fraction of a typical humanization program. And since first unveiling this publicly, less than 3 months ago, we've already made significant improvements in advancements. We've created new opportunities for our clients to produce safer, faster and cheaper antibodies on their way to the clinic. And at this time, we've actually queued around 10 different programs where immunogenicity and/or humanization have been added to quotes or statement of work just since unveiling this. And overall, in BioStrand offerings, we've now generated up to about $790,000 in BioStrand-specific service and quotes with over 80% of those being issued in the last 6 weeks. So our trajectory is pretty clear.
Martin Gagel
analystSo Jennifer? So how it roughly works, there's a drug company developing something and they need some antibodies, they've identified one out of a chicken that looks like it has some attributes that could be good for us. Traditionally, they would do the transgenic mode and sort of a lot of trial and error expensive and, I guess, do animal trials and so forth? Or they can contract out to IPA and using your hybrid of your -- in silico, I guess, the term is as well as some wet lab work, you turn it around much more rapidly and presumably with a much better or a smaller, more candidate list of antibodies that have probabilistically be more likely to do the job before doing further trials on it. Did I?
Jennifer Bath
executiveYes. That is a very good description of one of the paths that this can go. So if we take just a little bit of a broader look at what actually happens in our industry, I mean, clients can really start anywhere in a program. So they can certainly start with transgenic animals. But again, what we have found is they just don't have the same diversity or the same type of quality immune response as an animal that hasn't been genetically engineered, but they can certainly start there. And in doing so, they may not have to go through this humanization process but what we find is the quality of the lead candidates is lower. Now interestingly, what has also been revealed this year is that in several cases that have been brought to us, people are still getting lead candidates out of transgenic animals that still need to be humanized. So you go through spending all of these tens of millions of extra dollars and you're still having to go through the process it was built to avoid. One of the reasons that IPA is really successful with alternative species, whereas a lot of our competitors will offer mice and rats. And historically, that's where a lot of original antibodies were made because their antibodies kind of look very similar to humans, if you will, because their genetic relationship to humans is closer. However, you don't actually also get the same diversity of antibodies from those animals because they are so similar to humans. And so one thing that IPA has done over the last 15 years is to also branch out. We've branched out into all different types of species and our platforms are species-agnostic. So you can utilize any different species, and we are very, very specific about customizing that for you so that we can pick the right species to give you the most diverse candidates with the best probability of being successful. So we can work with the transgenics ourselves. We don't sell the transgenics, but many companies bring those to us. We can work with any different species but at the end of the day, what really matters is optimizing the diversity, optimizing the quality of the candidate and that's where we really excel. And that's where transgenic animals have struggled. So to really take the benefits of meeting a fully human sequence and then meeting the most diversity with the best candidate, we bring those together by offering this particular solution where you can use any animal that you want. You can start with the animal that's actually best for your program, and we can determine that through in silico analysis. And now you don't lose the time and the money associated with humanization and you don't lose the overall really natural diversity of an animal's immune system by going to a humanized animal. So we bring the best of both together, and so that's what enables us to turn out a better product, a faster product and a less expensive product. And so we really -- what we've really done is pinpointed the pain points for our pharma partners and then work to bring together multiple technologies to put together one comprehensive platform to solve those.
Martin Gagel
analystAll right.
Jennifer Bath
executiveAll right. So let's see I'm just going to share one more case study with you here. That's a little shorter. It's a fun case study and a little bit different in nature, in the sense that this is actually a small molecule inhibitor. So what we will share here actually really demonstrates the utilization of BioStrand's patented HYFTs and then its ability to extract valuable and actionable data from the biosphere. So what happened here was recently one of our pharma partners required the in silico identification and validation of potential inhibitors of an enzyme that they were targeting in the clinical trial. And the inhibitors needed to meet really very specific requirements for the client. And so this enzyme was already the focus of their ongoing clinical trial. And by employing a knowledge graph from our NLP and encompassing over 25 billion associations, including both structured and unstructured data, BioStrand not only successfully identified the active inhibitors but also prioritize them using our in silico docking and in silico molecular dynamic workflows. And our pharma client independently took the data that we gave them and confirmed the validity of all of the in silico inhibitors in their laboratory, including the accurate in silico-predicted rankings that we did of the relative strength of the inhibitors to bind to the target which we then actually rendered into an interactive 3-dimensional model, which you can see a static screen shot of up here on the right-hand side. And thanks to LENSai's platform, what happened here is that the screening requirements for this client reduced the number of inhibitors that needed to be screened from over 250,000 candidates to only 10. And that was really a powerful testament to the time and the energy and the money that we -- were saved by our technologies, also bringing together again in all these different modalities and one framework and different capabilities that enabled us to do something that we don't believe any other company would have been able to integrate and accomplish with their single technology. But more importantly, and I think the bigger take-home from this message is we were able to provide regulatory data for our partner in approximately one week, which enabled them to just completely move on with the rapid continuation of the clinical trial that had been underway. So it was a very successful program, and now we have a very happy client. So just to wrap things up here, having the Information Integration Dilemma, which I've described as solved, we're focusing on what our innovation enables for the future of science and health care. We believe that in the potential of our technologies to advance and pave the way for a truly personalized medicine in the stage for in silico therapeutic discovery. Our vision is the development of tailored antibodies uniquely adapted to each patient's needs. And you can see multiple ways here where we've already integrated these capabilities and these benefits into our laboratory in order to solve many of the problems and the pain points for our pharmaceutical clients. And so as I mentioned, our vision is to tailor these antibodies, make them uniquely adapted to each individual patient where physicians are then able to target the root cause of the disease by understanding the structural mutation at the molecular level, which is a core capability of LENSai and then personalizing each therapy to reduce undesirable side effects and then also to maximize the therapeutic efficacy. And just even recently, we've unveiled many different in silico technology offerings that integrate directly with our wet lab capabilities, providing considerable advantages to our clients. So we continue to unleash new potential from LENSai and to transform multiple critical sectors such as in silico, de novo, antibody discovery and development, also data organization and management, biomarker identification and early disease detection. This positions us for a significant role in the future of therapeutic antibody discovery and then by extension, as I mentioned, our goal of personalized medicines. The scalable and versatile and generic nature of our platform allows us to broaden our influence within and beyond the biotech industry without having to make any changes in our underlying technologies, offering really a vast field of commercial opportunities for IPA in the future. So we've recently laid out our specific path to commercialization and also the specific revenue streams for BioStrand and BioStrand-IPA combination revenue streams in last week's fiscal year earnings call and for anyone interested in taking a deeper dive into those revenue pathways, you can locate the transcript for this on our Investor Relations website and then just click under the sections Financials. So to wrap up this slide, we are in the process of setting the foundation for this future right now. Every action that we are undertaking today is bringing us a step closer to drastically changing how health care will look tomorrow. And the potential is vast, and we're really at the beginning of this drilling exploration, which is freely a lot of fun for IPA to watch this come to life. So in closing, choosing to invest in ImmunoPrecise Antibodies, it's not just about capital growth, it's about joining us in significant scientific and commercial adventure. You're supporting a transformative development that could reset the standards in bioinformatics and therapeutic antibody discovery and also development and a change that might remodel the medical landscape of the future. In essence, basically, your investment provides the necessary fuel to drive that innovative research and innovative business models, which could truly alter the course of health care. So that's all I've got for you today. But as you mentioned, Martin, we'll open up to Q&A, and I'm happy to answer any questions that people might have.
Martin Gagel
analystSure. I just want to, with your BioStrand acquisition and -- because I just understand broadly the business models. You have -- you are -- have been historically a contract research organization and you acquired BioStrand, which is an information technology company focused on the health care or the biotech sector. So currently, you're using the BioStrand technology to enhance and your own CRO operations and services. And doing it more efficiently and effectively. Am I right on that?
Jennifer Bath
executiveThat is absolutely correct. We've integrated multiple in silico capabilities into our wet lab offerings. Now what we do is we oftentimes just add them as a line item that improves the quality of the workflow, but also it improves our LENSai because it is effectively learning and enriching those HYFTs when we conduct this work. Again, without storing client data, which is unique and important to those clients. But also important for us, those in silico workflows that have been integrated into the wet lab, have very much faster revenue recognition time, so it doesn't take maybe like it would in a wet lab 3 months or 4 in the months to fully recognize the stage of a program that's oftentimes is a day or two and then extremely high profit margins over 90%, we're still working on doing the exact calculations as the research is still earlier stage. So that's absolutely true. We've integrated that into the wet lab, and then we have other ways also that we work with the in silico work. That's not a direct integration at the moment.
Martin Gagel
analystWill you be sort of, I saw the word SaaS on one of the last slides there. Will you be licensing it out so other wet labs either out of big pharma or other CROs can license the technology and use that as one of their tool sets so you would get that 90% gross margin, presumably on all -- on the appropriate work that they do with that as well?
Jennifer Bath
executiveYes. So that's a great question. We get that question a lot. And yes, eventually, we do intend to offer LENSai as a SaaS model. Right now is we're just rapidly adding capabilities to LENSai, one of the core decision factors that we need to make is which modules get added to that SaaS model? And are there different modules people can purchase. Right now, that overall platform that would be rolled into a SaaS model is not ready for that, it's in an earlier stage and not in a position where we would roll it out as a SaaS model. So that's why a lot of that work is being done on the fee-for-service basis as well as we're continuing to improve it. But that is our ultimate goal that we will roll that out into a SaaS model and enable people to do all of these sorts of calculations on their own and to develop the insights into their research right there within their own institutions.
Martin Gagel
analystAre you able to give any sort of a time line when that would be available as a service is at like at 2023, 2024 or further any kind of without a specific date, but just rough guidance?
Jennifer Bath
executiveYes. It's -- we've taken a look at that, especially in the last month or so. And it is a little bit difficult to pinpoint. So I'll throw that out as a little bit of a disclaimer. One of the things that impacts it greatly is the amount of capacity that we have to work on some of our other de novo in silico partnerships we have, the fee-for-service work and then actually the coding of various aspects of what will be that SaaS model. But some of our more recent analyses are looking at something maybe about 6 months from now where that platform could be unleashed. And then obviously, it would build gradually until it's being utilized by more groups and also building different modules.
Martin Gagel
analystWould you be able to offer it as a service to a big pharma where you go in and say, "You've got all these disparate data here and there. We're going to go in digest the data give you a giant graph and we'll charge you a service and maybe an ongoing SaaS type thing". Is that on the road map as well?
Jennifer Bath
executiveIt is possible, but one of the areas where we're seeing that sort of a question emerge, and we love this because what we've realized is that even though the companies are the same that want to build new therapeutic antibodies that they're the same companies that might be sitting on 20 years of data, 30 years of data disparate data, just like we talked about the puzzle pieces in all the different rooms and they don't fit together, right? And this has turned in a real problem really for almost every pharmaceutical company we've talked about and what has really been a wonderful finding for us is that even though the people that is literally like thousands of people that we know, we've worked with and identified as key decision makers for a therapeutic antibody programs, they may not be the person that's doing all of the data organization in that company, but they know them because it's the data from their experiments and labs that they're trying to organize over here. So we've had this great opportunity to begin that dialogue with a number of different pharmaceutical companies over even mostly really in the last month. All of them have the same story, 20 years, 30 years' worth of data, it's disparate, it's off different pieces of equipment, sometimes it's in people's written notes, it's clinical trial data, structural data. Help, what do we do? And so while we were discussing, yes, that SaaS model, what we're finding right now is that people are coming to us and asking, "Can you do data organization?" and we can. We can do data organization and we organize data in a unique way, because our data organization is being done in a way that enables the rapid analysis on the backside with our HYFTs. And we can do also the data management. And so one of the things we've been working on here in the development of being really able to take on larger programs for that is really fine-tuning those models, what that looks like, what the costs are on a competitive basis. And right now, we're in active discussion with 3 different companies that would really like for us to take on and tackle at least pilot portions of data organization and management. And then obviously, a big interest for them is that once they've done that with us, they can actually tap into the power of LENSai to analyze it.
Martin Gagel
analystAll right. Okay. Are there any other sort of models or that which I haven't asked about that -- are there permutations on monetizing this? Or is that the key potential pathway?
Jennifer Bath
executiveThere is one other pathway and that other pathway is actually collaborations with various partners where we really wanted to start utilizing everything that we're learning, all these different components that are being used to enrich HYFTs to move toward completely de novo in silico work. And interestingly, when we decided to go out and start looking at this as partnership models and collaboration models, we decided, let's take on the programs that some of our pharma partners have been working on for 10 or 15 years and haven't been successful. Let's take on the really challenging ones because that's the type of program we would expect to see people bring to a complex technology solution, which ultimately once we're not in a pilot stage, is going to be way more expensive than a traditional lab capability, right? If we were going to design everything in silico, everything de novo from scratch where all you had to do is say, make a drug against this and it's done within our software. And so we've announced a couple of partnerships, one with a company called BriaCell and one with Astellas Pharmaceuticals and that's a slightly different revenue stream where we said, this is early stage. We are learning from it. And we're definitely not saying these are all going to work from the get-go, right? This is our first time through this, but let us take a crack that the hardest thing you've ever tried to do, we will learn for it and gosh, darn it, If we are successful, it's a huge win for them. And so these are really partnerships where we're looking at in order to kind of take control of the product that we design in silico, there would be an upfront payment and milestones and royalties. And really, what we're finding is we have those two clients in the door, and we have a third anonymous client that's queued three programs, de novo in silico on also kind of an early adopter basis on fee-for-service work. And what we're really finding is these are the people who have been looking for ways to tackle the most challenging problems. And they seem to be the people that they realize it may not work on the first time through or the second time through, but they seem really more interested in being there on the doorstep and the first ones to know when it does. Because the ability to solve and develop a brand-new therapeutic completely de novo, completely in silico would be really transformative for any company.
Martin Gagel
analystOne last question for me before we go to the audience questions. With your CRO work leveraging the LENSai in that -- are you able to -- does that give you some pricing power to capture higher margins besides a 90% margin, you can accelerate the program, which time in the biotech industry is massive as well as if you get better results that potentially massive value for your client as well? Are you able to capture some of that?
Jennifer Bath
executiveYes, we are starting to capture some of that. So it's a couple of different ways. One, if you tie, and this one, we're at the beginning part of because we haven't, it takes a while for the in silico part to kick in if you're integrating with wet lab, you have to start in the wet lab. But what we're finding is that ultimately, as we're developing products in the wet lab and we tie in silico work on, the more that we expand the final number of good candidates, then the more actual work we get to do for those clients and continuing to move those quality products forward. Because they're not dropping out, they're successful, but also we're able to get rid of the undesirable candidates, and we're actually able to take good candidates and make more versions of them. So it actually technically expands not only the length but the quality of programs being analyzed a little bit further down on the backside. The other thing that we've really noticed is that the in silico work is so intriguing to a lot of our biotech and pharma partners that it's actually drawing people into the wet lab where they're saying, okay, now I'm going to bring this project to the wet lab because you can couple it with these in silico capabilities. And now you're offering us something that no one else was able to offer us. It's a competitive advantage that we're hoping to recognize. So we're seeing the impacts of both of those.
Martin Gagel
analystAll right. Okay. There were numerous questions on the recent 13D filing regarding the Board of Directors. What can you comment on that?
Jennifer Bath
executiveYes. So I guess we're not surprised to get that question. I think what's most important for investors to know is that the current Board of IPA is super committed to refreshing the Board. We have been searching for great directors. And we want to reiterate that we're really committed to that refreshment. And we're working on this process in conjunction with our investors, and that includes also the 13D filers.
Martin Gagel
analystAll right. Could you ask what is the average time frame required to carry out a wet lab experiment? And the question is, how long will it take for the BriaCell wet lab results to be announced?
Jennifer Bath
executiveGreat question. So a typical wet lab experiment, it -- obviously, it really depends on the complexity of the experiment and what the end product needs to be diagnostic or therapeutic and how complex it is and how much work they want done on it, right? We can do a tremendous amount of characterization for them, a lot of that giving insights into its potential success in the clinic or some companies cut off earlier and do some of that downstream research themselves. But in general, on an average, if we just take kind of an overall average of the program, about 6 to 8 months for a program from the time we started the discovery till the time that we've done the average amount of development work requested by a client. With regard to the BriaCell work, so we're continuing to plug away on that. We -- I think I mentioned recently in another call, we received back all of the in silico sequences that BioStrand had developed. We went ahead and generated from those actual DNA sequences representing 270 different clones for analysis, we've undergone some preliminary analysis of the products that those clones encode for. And we're continuing to look closer at all of the clones as well as some of the preliminary clones that we've moved on to the next stage. So that's where that particular program is that just continuing to incrementally advance. But on a time line, that's actually significantly faster than what we would have seen in a traditional setting.
Martin Gagel
analystAll right. It's been more than a year since you purchased BioStrand. What have been the biggest hurdles as well what have been the biggest, good surprises with the BioStrand?
Jennifer Bath
executiveI love that question. I love that question. So I mean the biggest hurdles, and we noticed this right away, and I think we're still constantly improving on it, is that we realized when we would sit down for strategic discussion that it's almost like -- I mean, it's literal and it sounds actually like kind of metaphorical as well, we're all speaking a different language. So it's the language and the words that we choose to describe when we're all seeing the same thing. And so making sure that when we're in a communication and in a strategic dialogue or we're planning a path forward, that were all actually understanding that what we have discussed and in the middle of our discussions and what we've concluded is the same because one group is speaking in their everyday language, which is really about data analytics. It's about coding, it's different word choices to describe what even might be the same exact topic that we're talking about. And then you've got another group over here that's using a lot of biological terminology. And so familiarizing both sides, everyone, all of the employees in the company because at this point, really the AI is touching every one of our sites, familiarizing everyone with that terminology and really starting to be in a situation where we can have a conversation to make sure that when we use certain phrases for instance in biology like epitope mapping that they have the same interpretation of what that is. When they talk about a variant color, we have the same interpretation of what that is. So that's been one of the things that we've been working on and I think always careful to just keep asking questions and making sure that we're improving that and that we're learning the languages of each other. And then one of the best things for us, we had a strategic meeting back in October, where we really asked ourselves okay, so we know they can do a data organization and analysis. And that was one of the things that they had initially set off to do and were initially seeking funding from different groups to do not necessarily an acquisition. When they integrated into IPA, and we sat down to talk about, right, how does their work really integrate with what we do in our vision and how we really look at some of the faster routes to commercialization, the things that can be integrated into the wet lab, the capabilities that we know our clients would want that they would pay for that they would buy, we identified some of the ones that you see today. So the immunogenicity testing is one-off target analysis where we do an analysis to see if we put this drug in you, is it likely to actually bind to other places, other tissues, other cells inside your body that might actually cause really severe adverse events or even death and several other technologies, target analysis and identification, et cetera. So we identified some of those and set off to launch those and integrate those, and that went a lot faster than we thought it could and a lot faster than I think other people thought it could. And I think one of the most rewarding conversations we've had about that is I believe it was back in kind of late May, one of the members of our client relations team Shuji Sato went out and presented that immunogenicity capability for the first time at a very large conference in Boston, two pharmaceutical partner peers and biotech companies. And then just thereafter at another conference, that's a very interactive style roundtable conference. And at that initial first conference after explaining exactly what we can do and a bit about how we do it, there was just tremendous feedback from the audience, including several AI companies and one AI company that said, we've been working on that for several years. And we're not close. Like we can't -- we have not figured out how to do that. And of course, we know that at the heart of our ability to do this the way we do it, it's the HYFTs right? And so it was for us, that confirmation that we get externally on the speed in which we've brought those to commercialization has been really rewarding. And now as we see them quite rapidly being integrated into quotes for clients. It's another further validation that has us feeling quite good about this progress.
Martin Gagel
analystAll right. Since the term AI and Chat GPT all started blowing up 9 months ago, there's been a lot of news and a discussion of that in the health care and the biotech world as well. In which way is BioStrand different or have advantages of the other AI platforms. Obviously, the AlphaFold is like the biggest name out there or the most well-known, but there are other ones as well, what are the different niches for AI in this? And how do you differentiate yourself from the other ones?
Jennifer Bath
executiveYes, also a great question. So -- and I like that example of AlphaFold because it takes us back to modalities, right? AlphaFold is able to work in a single modality. And one of the things that I brought forward was we can take you from a sequence to a structure with some decent accuracy. We have seen other AI contributions come out in the last year where there was a lot of hype around being able to actually take gene sequences and really be able to mass analyze these sequences more rapidly to be able to better understand the amount or the diversity of genetic sequences in the biosphere. So we had that at the genetic level, really DNA level, we had AlphaFold kind of at the structural level. So one of the things that's really unique about what we do is when people put those together and Facebook and Google are coming out and talking about those two capabilities, it was being routinely repeated that that's kind of where we get stuck because you end up with a structure of a protein, but what does that mean? You can look at it, right? But what does that tell you, if you don't actually know what the function of that is. When we're building drugs, when we're developing vaccines, when we're developing therapies, or when you're in agriculture and you're doing genetic engineering, anytime you're working with a biological molecule, the most important question or factor is what is the actual function and so we've heard it for quite multiple times and no one can go from structure to function, and we can through the integration of these multiple modalities in a single framework. So that's one thing that sets us apart. But even just that comment right there, multiple modalities in a single framework. I mentioned that Google had -- or yes, Meta AI had recently announced being able to take text and image, two different modalities on a single framework, right? And there are nuances of the imagery, but it was two modalities. And that's fantastic, and it was very widely talked about, but we're taking more than that. We're taking multiple modalities into a single framework and one of the things that the HYFTs -- so that's another distinguishing feature, but one of the things the HYFTs allows us to do, that's even further distinguishable is the speed, the low energy that's required because it doesn't matter how many sequences you put in, they get filtered through the HYFTs and the HYFTs don't just pull out the sequences, but they are pulling out the sequences and ranking them with regard to relative importance and then also the amount of data that you're getting back. And that data is not only immense in the knowledge graph but the data is giving you unique outputs, and that is also significantly different because most algorithms are going to give you very similar outputs because there isn't the proprietary HYFT technology at the core of it that allows you to parse it and get the insights that you would get through using LENSai. So that's several of the differentiators. I could probably keep going on because there are several that are really kind of at the core things that the HYFTs in part to that LENSai.
Martin Gagel
analystYes. As we all know, Chat GPT lies sometimes, and it doesn't know it's lying and it doesn't tell you it's lying.
Jennifer Bath
executiveAnd that's the black box problem, right? And our white box approach is really great because we've heard people say that in the industry, right? In the tech industry, they can't or won't use Chat GPT because of the black box approach. They don't know if what they're getting back is actually real, they can't track it back. Where you get the information, is it real? Did you make correlations that shouldn't have actually been correlated? We can do all that. And any researcher using LENSai can do that. And so they're able to go back and to validate and to be able to demonstrate. So if you're relying on that to make a drug that is really important. And if you're going to use that information to submit to a regulatory body, for drug approval, you're going to need that. And so that transparency is a really important part of what we do as well and another differentiator.
Martin Gagel
analystAll right. We do have a hard stop here in 10 minutes. I do have to jump then, I'm sure -- I know you're very busy as well. So maybe let's just hit through some questions here quickly. Can you please provide an update in the status of polytype?
Jennifer Bath
executiveAbsolutely. We've given several updates on this recently. There's not much more I can publicly disclose at the moment except for, obviously, our product was received significantly later than anticipated, causing us to adjust milestones and then obviously like miss our targeted date for other things that had already been queued like our clinical trial patient enrollment, patient enrollment and all of the documentation along with that. We entered into communications with that CDMO who provided those services and those communications have continued to get I think more and more advanced with regard to finding common crown and with regard to ensuring that there is some sort of mutually beneficial but also identification of a path forward that is somewhat of a reparation for IPA. And so because of the fact that we're in those conversations, it makes it a bit of a sensitive topic. So that's why we're sharing a little bit more limited information on that. But what I can assure investors is that they're active dialogues, they're constructive dialogues. It's 2 groups that really want to work together, that are making an effort to make progress on these discussions. And it just slows down a little bit because we've got other groups involved advising us to really come forward with something that works for both parties.
Martin Gagel
analystAll right. Will IPA start reporting in U.S. dollars rather than the current Canadian dollars? And if so, when?
Jennifer Bath
executiveGot you. Someday, but probably not soon. So what really drives that is we are still registered in Canada, and we are still a foreign filer and some of the things that impact that. One of the major things that impacts that is actually where the majority of our investor base is located. And the majority of our investor base is in Canada, and so as long as that continues to be the case, we'll still be registered as a foreign filer. Once that changes, if that ever changes, then that plus a couple of other criteria could dictate that we would need to change to GAAP financials and in that particular situation, I do believe we would then be actually filing in U.S. dollars.
Martin Gagel
analystAll right. Can you discuss the company's cash position and future sources of funding?
Jennifer Bath
executiveSure. So we just recently, a week ago, released our most recent cash position. So again, you can find that on the investor website under Financials. And in terms of future potential financing, so obviously, going back here over the last 8 or 9 months, you may have noticed that our prospectus in Canada expired and our finance team was working on filing a registered statement in the U.S., also known as an F3 and obviously, that's also something that needs to be done before an established banking relationship can be made as well. So we are -- we're really happy to demonstrate that last week. We did file our F3, does make us then, of course, eligible once that becomes active, which should be really any time now to raise money. And one of the things that we're really focused on right now is we don't need a lot of money, our burn is like maybe CAD 11 million a year. It's super small compared to our competitors that are burning $100 million, $150 million a year. And in part, it's smaller because some of the things that we need to do are scaled down because of the way that our algorithms are built. And in addition to that, we cut back on developing so many of our own therapeutic drugs, and we're working on actually selling those. And so with regard to raising money when we do, our needs are significantly, I think, less than what most people might think that they could be or what our competitors would be. But eventually here, we will be looking at going out to reputable groups. We have a lot of groups that have already been stating an interest, especially around the AI for the last 6 months. We just, obviously, can't bring them in. And the most important thing to us is making sure we're getting the best price that we're working with a group that's going to be into the long term that gets the value of what we're doing is going to also, I think, serve as a validation for the quality of what we're doing. And so yes, eventually here, we will be raising some money. And as I mentioned last week, probably somewhere in the range of around $5 million initially, but we'll take a look at again, the opportunities and look to be opportunistic while reducing investor dilution.
Martin Gagel
analystAll right. Is there any risk of not being able to meet the growing client demand with current facilities and resources?
Jennifer Bath
executiveYes. That's a great question too. We have tried in the past and really put a lot of energy into really expanding in kind of higher throughput, more automated or roboticized work, especially automation in Canada. Canada is -- our laboratory in Canada is a tremendous story of growth without expanding capacity. We went from about CAD 1 million when I first came in 5 years ago to about CAD 10 million in the same site, same capacity, same floor space and same number of personnel, if you can imagine. And a lot of that was done on enhancement of equipment and optimization of workflows. We did expand our site in Utrecht, that's our manufacturing facility. That also has the highest profit margins. They were sitting at capacity for a lot of fiscal year '22. They actually moved into a new building with Genmab and Merus in the accelerator building in Utrecht. And with only one day of downtime and within a week of moving in there, they immediately saw the initial jump in their revenue and have been able to continue to bring on clients and they're still sitting on about 50% extra space compared to where they were. So the Canadian space, they do need to undergo an expansion and they will. They actually will be consolidating most all of their laboratories, which are disparate in nature, kind of like siloed information into one lab, which will also gain a lot of efficiency and cost synergies for the company, and they'll be looking to start making that move and doing some renovations in the beginning of January. And then we've historically talked also about eventually oss needing to do that as well. Actually, the oss building and Pivot part was scheduled for demolition. And the new building is already underway being built. And so any company planning to stay at that location will move into the new building, and that will include us. And that will also give us more capacity at that space, which they're not entirely at full capacity, but they're close.
Martin Gagel
analystAll right. We do need to get wrapping things up here. My final question is with most companies I do. Just to summarize what sort of news flow and types of news should investors keep their eyes open for and expect obviously, not you can't get too specific, like types of deals or things you hope to announce in the coming couple of quarters near term?
Jennifer Bath
executiveYes, sure. So some good things to look out for that, I think, but also correspond to milestones. Obviously, any sort of event where we're making unprecedented headway in the in silico de novo discovery space are things that we would release at least on these initial partnerships because the way that we model those early adopter programs were ways that would give us the right to announce if we were able to do something like that, that would be really, I think, fundamentally kind of a disruptor in the in silico space. In addition to that, I mean, one of the things that I think we're finding fascinating is just how quickly we're developing new capabilities and solving new problems with this AI. And so one of the things we've been trying to do, and I think has been met pretty well in the investment community based on feedback is file nonmaterial press releases without that 8-K wrapper just describing to people the advancement like this IID solution, solving the IID so that people can really start to understand how we're doing some things that have never been done before and exactly we differentiate ourselves from those competitors. So I definitely would be on the lookout for more of those. It seems to be even surprising us how quickly these different things are coming about. We're working really hard on additional collaborations within BioStrand again, some fee-for-service, but also some additional partnerships. So I would always watch for those as well. And then who knows. We're working on a lot of things. So there's a lot of different milestones we might also potentially hit. But I think these are things that you can expect and you can watch for in terms of press releases.
Martin Gagel
analystAll right. Jennifer, thank you very much for taking the time to chat with us. That was a lot of great information. All the best, and we'd love to get you back here in a while after you get some of those announcements out and get an update on how business and your breakthroughs are progressing.
Jennifer Bath
executiveThat's great, Martin. Thank you so much, and we'd love to join you again. So all right. Thank you. All right. Bye.
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