Pfizer Inc. (PFE) Earnings Call Transcript & Summary

June 10, 2024

New York Stock Exchange US Health Care Pharmaceuticals conference_presentation 38 min

Earnings Call Speaker Segments

Chris Shibutani

analyst
#1

Okay. Let's kick off our discussion with Pfizer here. My name is Chris Shibutani and I am a member of the Goldman Sachs health care research team. Thank you so much to everybody here for joining us for this conference and for this discussion. Super pleased to have Albert Bourla, CEO of Pfizer, to join us here and sit down and have a conversation extremely timely, so many things to cover. I think your team had wanted you to be able to just sort of kick off with a couple of opening comments maybe to contextualize our discussion and we'll go from there.

Albert Bourla

executive
#2

Yes, of course. Thank you very much for being here, everyone. 2023 was a difficult year for us when it comes to our stock performance. We're very disappointed to see that happening. We try to understand the reasons and try to make sure that we have a plan to bring it back. And then we announced our plan earlier in the year in '24, and it was based on 5 points. The first point was we need to make sure that we integrate Seagen in a way that we develop oncology leaders. I think that is going very well. We presented our first quarter results but so that not only the Seagen and oncology business internal didn't go down, which is the expectations in the first 6 months of every merger because people are changing brands and people are changing customers and bosses and all of that. Actually, we had a growth, which was very impressive. And then in ASCO, we had significant presence of a pipeline, which is the second priority that we have to make sure that our pipeline continues to evolve. Oncology is a very big part of it, but not only. We have right now a lot of readouts that we expect by the end of the year. The third priority was to make sure that all these new launches that we have done will perform well that will maximize the performance of the new launches. We did an unprecedented number of new product introductions in basically last year. And we're not that happy with the way that all of them went commercially. So we took some measures in the commercial operations, so to make sure that, that will work well, and that's a priority for us. Capital allocation is a very clear priority. Dividend. We said multiple times in the sacred cow. So this is number one. Second, of course, delevering our balance sheet and paying down debt and, of course, increase EBITDA to delever. You can do -- you need to do both. We'll be able to deliver. And then, of course, investing in the business and buybacks. And those were the fundamental things that we said that we are going to do. And we are -- I think that Q1 was quite good. We had a good progress towards all of them. And I'm looking forward to present to this discussion to start with and then to present our results of the second quarter at the end of July, I think beginning of August.

Chris Shibutani

analyst
#3

Okay. Terrific. I think that really captures a lot of the key points that we'll try and get across in the next half hour here. A lot of structural change and signals an adaptation of your strategy to the difficulties that you had in 2023. I do want to bring up because we're in front of a Wall Street audience that there was a point person who was brought in recently. Many of us know Andrew. I was a client myself 10 years ago. Andrew is probably on the live webcast. How is it going Andrew? Talk about the appointment of his position within the company. And I think from a time line standpoint, actually, you made some decisions about structure, oncology, U.S. and international. So to a certain extent, he's coming in midstream as we're ramping towards executing on this new strategy, but second to be like to have a whisper like him with you? And how do you think about that?

Albert Bourla

executive
#4

We're talking about Andrew, I think it's extremely important for me to have him be my third partner and the third partner of the leadership team of Pfizer. He's someone that is uniquely qualified to do the job that Amir Malik was doing before, which is a drop-off strategy, business development, capital prioritization on pipeline, which products are getting funded and not. The overall strategy of the company. So he has a medical background and he has a very good financial background. So he combines those too. He is extremely well respected from all investors because of -- he's very thoughtful and this is what I appreciated on him. He was not the most positive on Pfizer as we all know. But I think that, first of all, the demonstration that we are not looking to bring a yes man. We are looking to bring someone that can bring fresh ideas to our business. And that's what he's supposed to do. And also, of course, you should ask him yourself, but if he accepted to come, most probably he saw something that worse connecting his name with.

Chris Shibutani

analyst
#5

Excellent. And I think it'd be very constructive to have someone who always has a little bit of a critical tone to a certain extent. How should we measure his performance? I just think about what Amir joined was very quick to come out and say, "We're going to put through capital deployment, M&A, $25 billion in revenues in the year 2030, based upon all the deals we're going to do between now. Mark my words, watch me go." And he did accomplish a very significant amount. What's the right cadence to think about the impact of this? Because I think you reset a lot of the pillars of the business. You have some folks in place who are relatively newer in their roles. What's the right way to measure because I get the sense that investors are a little bit in sort of watchful waiting, not wanting to give you too much of the benefit of the doubt mode at these levels.

Albert Bourla

executive
#6

The Pfizer that Amir found when he came is a very different Pfizer, right? We're much bigger. I remind you that in the Pharma division, which is the one that we have, we have $37 billion of sales in 2019, now it's $60 billion of sales. So it's way bigger, right? We have just completed significant acquisitions of this $25 billion revenues, but they are all there, and they are all about to be executed. But that also found Pfizer in an inflection point of going very, very high in terms of reputation, revenues, stock price through the COVID period. And then when COVID subsided losing a significant part of that. So we are trying to find our next wave of impressing the investors. So how we're going to measure his success, I think all the success of all of us be measured on the surprise. And frankly, the things that Andrew is doing are things that are influencing significantly the stock price because pipeline in pharma is the most important driver of stock valuation. And this role really significantly in controls, which projects we are investing and which we are not investing. Andrew is going to be the Chairman of -- as part of his job of the total -- the most senior governance body that makes the decisions of this capital allocation. Business development is an extremely important thing. Commercial development is an extremely important thing. So stock price, I think, eventually, is what we need to -- we will be looking for all of us.

Chris Shibutani

analyst
#7

Focusing on now sort of the center of gravity for the company. Oncology is really put to the forefront. Interestingly, you structured its oncology is the therapeutic area for that business, then you have U.S. and then international. So oncology really getting highlighted here. We're coming off of the ASCO meeting, maybe highlight for us what you think is going to be something that we can really spend our time focusing on. Clearly, the Seagen legacy was across antibody drug conjugates. We have [indiscernible] as a notable success from recent late-stage data. But in particular, what's the right measuring stick for the progress with this oncology business coming out of ASCO for you guys?

Albert Bourla

executive
#8

The way that oncology stood out in the way that you organize the businesses because we organized the business to make sure that oncology will be -- will get the best chances to be successful. The acquisition of Seagen was the largest acquisition of the last decade for Pfizer. And it is not only the amount of money that we are investing on that. But it's more important, I believe, that has the potential to become the most successful acquisition that the company has ever done. The acquisition of Seagen was a bet on a technology, which is ADC and on a company which is Seagen. Both of them, since we made the decision, have made significant strides to believe that these were the right decisions. The ADC has become after we announced the hottest M&A commodity right now. Everybody is trying to find an ADC, but no one can find something that we found with Seagen, which is a whole platform of 4 products already in the market at early stages of their launch. So they have a lot of potential going up, plus 13 late stages, let's say, development program plus a significant amount of pipeline plus an infrastructure of people. So they presented following acquisition tells us that probably we made the right decision [indiscernible] the big company acquiring a small company like Seagen [indiscernible] and biotech, the most common [indiscernible] is that you take the company you can trade, you cut the innovation, you bring it into your bureaucracy, and that can reduce dramatically our value. So the entire effort from the day we announced was to make sure that, that will not happen. That's why we created an integration team from the 2 companies. That's why I selected the person that I felt not only has this [indiscernible] not only has the scientific depth and rains to do some -- job like that, but it's also a good manager, someone that people will follow, somebody we would like and someone who makes decisions based on meritocracy, not based on legacy. Most of Seagen people told me, I want him. So that's why we did all of this work. The integration was completed extremely successful, and then watched us took over the entire thing to lead and the first months are very, very, very impressive. So I'm very optimistic about the future of this acquisition.

Chris Shibutani

analyst
#9

Yes. And you're referring obviously to Chris Boshoff here. And it's interesting because his responsibilities are both sort of guiding the ultimate portfolio, the pipeline as well as on the commercialization side. And I listened at ASCO, he participated in a conversation where there was this question about whether he has to talk himself into certain things. And so when you think about oncology, where do you think the higher priority is? Is it on pipeline and on the come, which I get kind of a sense for, if I think back to the end of February, when you did your oncology day, a lot of folks were being paying attention to the entire scope of the presentation, there is a fair balance of Phase 2 as opposed to talking about the commercial product with Chris having to wear both of these hats and kind of debate within himself, where would you say we should focus? Is it more on the pipeline? Is it on the commercial side, where you have a pretty clear footprint? Just a sense for what makes sense.

Albert Bourla

executive
#10

You can differentiate, you need to focus on both. You need to make sure that your current in-line products are performing very well, and you need to make sure that you have a pipeline that will come. Oncology, the commercial part of oncology is very different than the commercial part of vaccines or primary care or even specialty. It is extremely, extremely data-driven. The sale of oncology, the selection of a brand compared to another, has nothing to do in oncology with the brand's equity or if your ad was good on the news, which affects [indiscernible] communicate data in a way that compelled, but yes, that's the solution. So from that aspect, I don't think for anyone that has this belief in oncology for that many years. It's very difficult for him to pick up some of the nuances of payers and some of the nuances of rebates. But he is focusing on -- I have seen him being more better in commercial many times in the past. But keeping [indiscernible] that's not what he does, day in day out, right? What he does day out, it is managing the entire vision of the oncology. We have Suneet who is doing the commercial. And then we have Roger Dansey, who is doing all the development as Chief Development Officer. And then we have a settlement that he's doing the early development. Chris is supervising all of them, and he's the right person.

Chris Shibutani

analyst
#11

Thinking about the footprint, obviously, having a bicoastal kind of presence, you talk a lot about how -- actually, Chris talked about how the Seagen business was relatively similar size to the legacy Pfizer business. So it was a little bit more of a merger of equals and you're keeping the management teams roughly equally balanced, how sustainable and relevant is it for you to be at in Seattle? I'm old enough to remember Genentech-Roche and sort of thinking about how that was across so many time zones and became a little bit of a tactical sort of struggle here. But -- and then I also think about Pfizer deals historically, Array and Boulder, Rinat and San Francisco. There is a long-standing tradition of large-cap pharmas acquiring smaller entities, having some initial process of capturing value assets talent but then not necessarily having a footprint there. When you and I are sitting here 4 years from now, knock on wood, should we expect to see Seagen in Seattle and that being a success formula for you to have that footprint there?

Albert Bourla

executive
#12

Absolutely. We are highly committed to the Seattle side, and we will develop it even further. The examples that you gave from Boulder and not in San Francisco, those they were a rounding error in terms of size compared to Pfizer at that time, right? So it was a small group of 150 people in Boulder or in Rinat, right, and we have thousands of scientists. As Chris told you, in R&D, the size of Seagen organization was equal to the size of the Pfizer organization. So really, we doubled our resources and we doubled our budget and we doubled our pipeline. Commercial, they had 1/3 of the whole. So we were double than them. So if we are 2/3 now, they are 1/3 in terms of commercial reps. And of course, they were not international, so we are internationally. But the R&D, which is what Seattle is all about, it's a very sizable organization and has tremendous value for us. So we are going to develop it even further.

Chris Shibutani

analyst
#13

Question again about pipeline prioritization, how important it is, it seems to be in oncology to be best-in-class even if not first-in-class. And I think about some of the areas that you're quite relevant, but it's competitive, for instance, in breast cancer. You have pipeline of some efforts around CDK4 as opposed to just the legacy of IBRANCE there. Anything about how that realm will shape up and where Pfizer wants to be, particularly where you already have such a franchise, but it's competitive and thinking about best versus first-in-class for the next generation.

Albert Bourla

executive
#14

Breast cancer is the most common cancer of the female gender. And by the way, prostate cancer is the most common cancer of the male gender. And in both of them, we have current significant products that they are the product leaders, IBRANCE and XTANDI. But in both of them, we have a tremendous pipeline. Let me focus on the press that you just spoke about it. Clearly, we have the CDK4 that it is presenting a significant opportunity to bring next generation. But we are having right now also a lot of ADCs that are targeting breast cancer. And we have also protein integrator, but it is also on breast cancer. Actually, the protein integrator we're expecting data this year, right, from Phase III study, which I -- that we hope will be positive. And then, of course, protein integrators can be used also with ADCs and we have a lot of ideas on how do you combine it with ADCs, not combine as to drugs necessarily, but I'm talking also about putting the drug part of the ADC conjugate. So breast is very important for us, but we have a franchise on IBRANCE that we are going to defend commercially as we go. By the way, there is a study also on [indiscernible] which is about HER2 positive with IBRANCE. Breast is a very big part of what we are going to continue doing.

Chris Shibutani

analyst
#15

You brought up a lot of different modalities. Maybe I can ask you to touch upon what your -- what the firm's view is on thinking about some other modalities, radiopharmaceuticals, for instance, another very highly topical active, engaged realm from a business development standpoint. What's the Pfizer house view on radiopharmaceuticals and your interest?

Albert Bourla

executive
#16

We are looking at it with high interest. It's not that we have made our decision to enter into that space. We are focusing right now on 3 different modalities when it comes to cancer, a, disease, of course, big priority, small molecules, of course, very big priority and the power strength of Pfizer and bispecifics antibodies, right? So anorexia was one of them. So those are 3 modalities, that we are focusing on the therapeutic area to urothelial with prostate and bladder cancer included, breast, thoracic and blood cancers, lymphoma, leukemia, et cetera. But this doesn't mean that we are not staying close to science as it evolves. And the moment we feel that we can make a difference with a new, including what you said, we will jump into it.

Chris Shibutani

analyst
#17

Got it. Let's move on to a little bit some of the other therapeutic areas and businesses. Obviously, the COVID portfolio and more broadly vaccines. We're actually seeing an update from your competitors today and the combined COVID and flu, update us on where you guys are with your efforts and how we should be thinking about whether or not if we see similar data, which appears to show that the combination actually gives you a more maybe advantaged profile, will this possibly help the sort of penetration in the U.S. What's your view currently on the outlook? And I know that you have some data coming as well.

Albert Bourla

executive
#18

Yes. We were very vocal that we believe a combination of COVID with flu will probably accelerate the COVID penetration because flu, it is way more administered than COVID right now, huge difference, right? So particularly in young population, the difference is dramatic, right? People are getting flu vaccine, 50% but there are very few of them are getting COVID vaccine in the younger age. Overall in the population, 50% compared to 13%. So the convenience of being able with the same visit that you are doing in the pharmacy, to get your flu vaccine also with the same injection with zero co-pay, nothing of your money to cover it also for flu. And COVID, I think, will drive several people to also top for this choice. So as a result, we are working on that as well, and that's why also Moderna is working on that. We have our study, which is on the 18 to 64 that is on a trivalent vaccine, the flu which is the new recommendation. I think the Moderna's data that the release was a tetravalent. So probably, they will deal with that later. But we're awaiting the data, I'm optimistic that the data will be good, and we are waiting to proceed.

Chris Shibutani

analyst
#19

Last year was a difficult year in terms of thinking about the forecasting of the COVID revenues. It ended up being the actual delivery disappointed, and there were several set points. And I would say that most of the investors that I speak with thought about the final set point that happened kind of at the end of the year into this year seemed as if the pendulum had swung quite securely to the point of, well, I can't miss this number. When I say that, how do you feel about that? To a certain extent, I feel as if that would be very important.

Albert Bourla

executive
#20

Yes. Last year, it was a disaster the way that we forecasted. We thought that COVID will go. We hit everything else. When we speak about the non-COVID business, we were from our initial guidance. But COVID was a huge difference. That's the statistic to make sure that we all understand. During my tenure as CEO, we have done 21 earnings releases, right? 21 earning releases, 5 years x 4 plus the first one of this year, 19 of the 21 we beat EPS. Bloomberg, 19 of 21. So it's not that we are used to miss, just to make sure because people's memory sometimes is driven by the latest and not necessarily by the fact. Now your question, are we going to make our numbers? Yes. I am very confident that we will make our numbers. We gave the COVID numbers, particularly or very confident because that was also the specific of your question. Keep in mind, we said it multiple times, that 90% of the vaccines that are respiratory driven are coming in the second half of the year, right? That includes not only COVID, includes RSV, includes -- so we expect 90% of the sales to be on the second part of the year. And by the way, I see that a lot of the analysts feel you have it right, for the second quarter. When I say you have it right. You are forecasting that the second quarter in your estimations is small in COVID and the third and fourth is very big. Not everybody I think have noticed that we repeatedly have said and also that's the trend that is happening. PAXLOVID, we already had a phenomenal start, right? And PAXLOVID is highly, highly correlated even today with the COVID case. So when I see the weekly sales of PAXLOVID going down, I know but the severity of COVID is down. When I see going up, it's very, very inelastic. It's very correlated -- highly correlated. We will make both numbers.

Chris Shibutani

analyst
#21

You mentioned about the RSV, actually, one of the more compelling products when you think about what Street has for 2025, '26, it really becomes material. You were somewhat brutally honest in terms of what the early commercial performance has been, which is -- has some mix components to it. So now we're going to have potentially a third entry here, which everyone has been anticipating. So how can you win in RSV?

Albert Bourla

executive
#22

In the RSV, we were surprised positively with the market. Everybody basically became bigger than what we think. So as a result, in RSV, we did more than what we had in our budget. I'm very honest. But I also was very honest to say I was very disappointed because this better than budget performance not because we had better performance in the market because the market was bigger. GSK took 2/3 of the market, right? And we have 1/3. And that's not something that we are settling with. We should be better than GSK, not 1/3 to third. Now the reasons why that happened. When you have this discrepancies on market shares, one can say maybe the products are not equivalent, actually. We don't have data to have comparative data between Moderna, GSK and us to see who trends better. But based on the profile that all companies have published, we are clearly superior product. We are the only ones that we have A and B. We are having very high numbers in the first year, and we had extremely high numbers in the second year when others were fending. So we are a very, very good vaccine. The reason why we got in the physicians' offices, we had the lion's share of market share. With RSV though, the biggest part of last year's sales were not on physician offices, was on retailers. And DSK had earlier approval, the mass and have already signed a lot of contracts last year with retailers that gave her. This was not a choice of the people. It was -- that's what is available in the pharmacy. We -- from the beginning of this year, started renegotiating all our contracts. And by the way, the product is also running outside the U.S. But in the U.S., all our contracts -- and I don't want to speak about it. We'll see what the results will be. But all the contracts are 1 year. So whatever happened last year was until basically the second quarter, right, starting from the new flu season, which is basically August, September, October, November, December and then going to next year, it's going to new contracts, and I hope we'll have better position than what we had last year.

Chris Shibutani

analyst
#23

Okay. Let's touch on some other areas, metabolic disease, obesity, very logical from a Pfizer standpoint, the House of Lipitor going back a decade ago, a difficult journey with the pipeline assets that you've had at this point. What is your appetite for still being in there?

Albert Bourla

executive
#24

Very high. The reasons are very, very simple. One, the market is real and is big. The classes that we start seeing, they have some disadvantages, but they look very good so far, right? The GLP-1 that it is the first class that is coming. And it's just scratching the surface of what we will see in obesity. And Pfizer, as you said, has a very long tradition in metabolic diseases and in, of course, primary care commercialization. So it is an area that we are investing and we will continue investing and will be part of it. Now we had a first choice that unfortunately failed back in the day, I mean, a year from now -- a year ago. That was Dilaudid 1, failed because it had safety issues with liver enzyme elevations, which happens in those in drug discovery. So we feel things would be extremely different for us if we didn't have those liver enzymes because we would be the first one probably to come with an oral obesity or together with Lilly at worst, even that we didn't have that setback. Then...

Chris Shibutani

analyst
#25

The asset in the clinic right now, Phase I, but -- are you comfortable with what you actually have in-house that's currently in the clinic? There's a little bit of a time rate here versus our -- how acutely are you paying attention to what's happening around because there are plenty of small companies that are popping up with demonstrating some data that looks like they could go to the next level. So.

Albert Bourla

executive
#26

Absolutely. And we are looking all of them, and we are having also our own efforts. What we have in hand in the clinic right now, there are 3 different molecules as we have said. One of them is danuglipron, that we presented data, and then we said that we are going to first way to see if we can convert that once a day. And we said mid of the year. So mid of the year is June, July, that's basically the time frame that we should be having data on that. So we are waiting to see. Hopefully will come on time. Then it had 2 other ones that we haven't disclosed the mechanism, but they are in the clinic right now. And we have a lot in the pipeline. Also, I want to say that the injectables are the ones that are having most imminent competition, right from everyone who has something presented so far, that is coming by year '26, '27, it is injectable. Orals, there's only Lilly right now and then us and then AstraZeneca. But I think we have at least 2 years difference, it's one of us. So us being in the middle, AstraZeneca been 2 years later than us and if we do danu. And then Lilly been 2 years earlier than danu you if they are successful. All of that is if.

Chris Shibutani

analyst
#27

And then help me reconcile. So Amir's goal of $25 billion in revenues by 2030, I think based upon everything that was done, whether it's Seagen, you add $10 billion, $10-plus billion, arena, global blood, everything put together, still gets you to about $20 billion to $21 billion. The priority is to pay down. So your capacity to do business development, and this is intentionally linked over to obesity metabolic disease just because it is such a hot area, and we also talked about radiopharmaceuticals. Should we expect you to do more tuck-in acquisitions? Or is this a little bit of a breathing period because of the priorities the way you rank them for [indiscernible]?

Albert Bourla

executive
#28

It's a briefing period, not because we need to pay debt and we don't have the capacity to do business development. We can do both. Right? It's not that the problem. What it is -- the strategy is that we have just invested $70-plus billion in the last 18 months, right, in acquiring things, very important investment for the company. We need to catch our breath and make sure that we execute well on those that we have right now. So that's the priority. All 4 of them. Now I'm very optimistic in all. And probably, that's good, we can even exceed the projections that we have made without changing the numbers that I have committed, but I think season has surprised us very positively with data and the performance and the integration. And I think NURTEC will surprise us very positively going forward. So all of that, I think they look good. But that's the reason why I don't foresee ourselves going and buying something sizable now because I don't want to disrupt our commercial operations, our research operations or as they are doing manufacturing operators as they are doing the work that they are doing to execute. Smaller things that they are coming just the intellectual property with it, like an obesity molecular is here and there. Yes, we are oncology, the same. We are looking at them. and will happen probably this year as well, but these are smaller things. And for the '25 let's say, that is by year 23. There are a lot of years...

Chris Shibutani

analyst
#29

Yes. No, you've got some time in that has been pretty consistent with that. In the last 5 minutes, I want to take advantage of the fact that you are a CEO of one of the prominent companies here and to talk about a bigger picture issue and that would be the IRA processes that's unfolding. Two topics that investors seem to care about. How is it going? I know you and your partner Bristol are involved with Eliquis. And to the extent that you can give a side eye or give us an eye roll or something, I think when we were talking to our DC policy consultants, it's been kind of an interesting first year, but no one is really smiling. And then secondly, Medicare Part D redesign, 2025 implication. So maybe let's start on the second question. How should we think about what the House Pfizer view is about the redesign impact on kind of the revenue forecasting because some companies have sort of been optimistic and then pessimistic.

Albert Bourla

executive
#30

I think it's not about the revenue forecast in the next few years that I worry because there are drivers that are pushing it down and drivers that are pushing it up. So I don't think that's the problem. I think the main problem of the redesign of Part D, it is that they are having this nonsense of the penalty of the pill that is going to create these advantages to oral molecules compared to large molecules on the long term. And by the way, these are balancing both because they are putting that up. But the things are more intense in the small molecules. So that will force a lot of us to make strategic moves, not based on where the science is taking us, but based on where IRA is taking us. I mean one of the reasons why I was hesitating 0 to write a $43 billion cheque for Seagen, it's not only that the technology, I want it in the company, I wanted, but also they are large molecules. So basically, they don't have these problems of the small that IBRANCE could face. Now going back to the negotiation and first of all, I have to say that we were lucky as Pfizer, why I'm saying that? Because there were more products that could be selected because they were fulfilling the criteria, XTANDI, IBRANCE, [indiscernible] and Eliquis were selected. Now of course, they may be selected in next year. But even if all of them would select in the next year, it's very small the window of patent life remaining anyway. So the NPV that we are going to lose because of the price reduction of that is small compared to it00. The discussions on [indiscernible] they are ongoing. It is -- our partner is the leading in the negotiation, but they do that in very close collaboration with us. And basically, we agree everything. And I can't comment because it's ongoing.

Chris Shibutani

analyst
#31

And then immediately after the framing of the IRA was done everybody was thinking about the next derivative. It's like, oh, this is going to impact clinical development strategies or everyone's going to shy away from small molecules versus biologics, et cetera. Then you get a couple of laps around the track and people get to calm down. Some people still believe that that's very critical towards ultimately being in your planning war rooms and deciding where you're going to go and when you're going to go earlier, et cetera. How relevant is mind the fact that IRA seems to be moving down the track here?

Albert Bourla

executive
#32

Look, I mean, looking historically, I can see as a CEO that the large molecules are winning in general because they have longer duration. It's very difficult to make biosimilars. Actually, in ADC, it's almost impossible to make biosimilars because they are free. Biologics over there, I don't think it's regulated how one can make biosimilar. And is contrary to the -- so you can see that large molecules that they are successful products, even they have life even after the patent clear. And clearly, the IRA is giving you a very clear difference between the two. So yes, we are looking to more favorably large molecule. Keep in mind that in our oncology, we have right now 95% small molecules, 5% large molecules. Within 5 years, we will be 60%, the large molecules, or 65%. I'm not sure the number you have it, right? But it is this the magnitude from 5, right? So it's very clear that we are moving there.

Chris Shibutani

analyst
#33

Great. Two last questions. Do you get the ultimate sign-off on that Super Bowl commercial.

Albert Bourla

executive
#34

Yes.

Chris Shibutani

analyst
#35

Are you a Freddie Mercury fan?

Albert Bourla

executive
#36

I am, but I consider that a lot before I give the final sign off. I like it a lot. The spot was fantastic. My concern was at the time that our stock price was down, do I want to solve to invest and we spend money in Super Bowl. So I consider that a lot, if I should do it or not. I made the decision, but it's so important to solve the world that we are moving to oncology because that was just after the Seagen acquisition, and that was speaking about everything. It was the 175 years of the company and even more importantly, from a commercial point of view, I have repeatedly see market research, repeatedly, that the brand equity of Pfizer is extremely higher the recognizability of Pfizer. Everybody knows Pfizer. Everybody may know if you are an investor of Lilly, but the recognition of the Lilly or any of these fantastic companies. So the fact that you want to make brand equity for Pfizer, for products that you can make at soys, vaccines, primary products, the consumer plays a big role in that clearly creates a difference. So for us, that was an investment in brand equity of Pfizer that paid actually -- I saw the results following tremendously. It was tremendous success on that front.

Chris Shibutani

analyst
#37

Okay. Well, a very happy 175th anniversary of Pfizer for a year of execution.

Albert Bourla

executive
#38

Year for execution. Q1 under -- water under the bridge, but Q2 is coming when we are focusing on it until the last day and then Q3 and Q4 hopefully, we will turn the corner.

Chris Shibutani

analyst
#39

Great. Albert Bourla, thank you very much.

Albert Bourla

executive
#40

Thank you.

This call discussed

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