Repligen Corporation (RGEN) Earnings Call Transcript & Summary
May 14, 2024
Earnings Call Speaker Segments
Conor Noel McNamara
analystGood morning, everyone, and welcome to the RBC Capital Markets 2024 Global Healthcare Conference. I'm Conor McNamara, the life science tools and diagnostics analyst. And it's my pleasure to welcome Repligen. Up on stage with me are Jason Garland, the CFO; and Steven Chehames with IR. Thanks for joining us today, really appreciate it.
Jason Garland
executiveGood morning, everyone. Thank you.
Conor Noel McNamara
analystJust from a high-level perspective, Jason, you joined the company recently. Can you walk through your decision to join the company and what really attracted you Repligen?
Jason Garland
executiveYes, absolutely. So I spent about 20 years in GE across a lot of different industries, but spent the last 5 before Repligen on the med tech side of health care and got a bit of the bug just to stay within the health care space. And wanted to understand and see more of Life Sciences and really from a reputation and a growth and what the value creation that Repligen had, it was hands down one of the highlights in the space. For me, I can remember the very first conversation I had with Tony saying, we're a scrappy company, right, in terms of highly focused on innovation, roll up your sleeves, get it done, move quickly, help customers and looking for someone that wants to be a part of that. But then also know that we're at a point in our company where going from that smaller player to a bigger one requires learning new muscles, right, and new levels of sophistication and processes, and that's some of the experience that I can bring and help the company. So it's been a great transition for me and Tony and the team have been fantastic to work with and a lot of good times ahead.
Conor Noel McNamara
analystGreat. And just continuing on that. If you look at the last decade, first off, bioproduction is one of the fastest-growing markets in life science tools and Repligen has grown above the overall market. And sometimes when a company makes a transition from maybe growth to profitable, they bring in a new CFO. Is there any -- how do you give investors confidence that you weren't here to kind of take advantage or try and maximize a slowdown in the revenue growth as you're here to continue the strategy of growing above the bioproduction market.
Jason Garland
executiveThose things go in concert so well, right? I think growth and profitability. So for me, it's helping the team to recognize there's absolutely leverage you get with top line growth, right? And if you manage your costs especially your operating costs and you'd always grow that at a level lower than your growth rate of your revenue, you're going to get pulled through on that. I think what my observation and I think what the dialogue I had with Tony coming in was, when you're in hyper growth and then throw COVID on top of that, your whole focus as a company is getting product out the door, securing new capacity, new space and focusing on that, managing cost is like tenth on the list, right? And so now as we sort of get back to and manage '24 and even if '25 isn't back to that same -- takes a step up to double-digit growth, but maybe not to where we were before, how do you -- how do I help the team bring in a level of discipline on that cost management and get it back maybe forefront. But I think you can absolutely do that without forwarding growth without encouraging it and just making sure that it's not tenth on the list anymore, it's second or third. And I think that that's an important part of what we need to do as a company to create value is that profitability as well.
Conor Noel McNamara
analystSo just sticking to the growth side, Repligen built out a lot of capacity during the pandemic. And just if you think about winning new business, maybe it's larger contracts or longer-term contracts with certain customers, how well is the company positioned to leverage that capacity to reaccelerate growth as we kind of exit these headwinds?
Jason Garland
executiveYes, and we're very well positioned. We look at really having -- if you think about capacity, at a high level, I'd say there's 3 pieces. There's the footprint, right? The physical space, there's the equipment that you need to create the products and then the workforce, right? And so for the footprint, especially, we feel we're good for the next 3 to 5 years, right? I think the equipment piece, we've got absolutely headroom, but where we need to add, that's manageable. And I think our labor force, we can flex appropriately. We don't -- we like to keep the right, I'll say, expertise, right? You don't want to turn over your team completely, but we can flex there and we can certainly add. We're still an attractive industry, attractive company to hire people. So for us, finding though, the -- I'll say the companies that need space may be starting in clinical and then being able to ramp with them. Absolutely, we can do that all day along.
Conor Noel McNamara
analystAnd you mentioned your experience with GE and your 20 years of experience. As you walk into Repligen, when you walked in on day 1, was there any low-hanging fruit that you say, hey, there's this that best practices we could do this right away to kind of help margins or whatever it may be, is there anything like that, that you see?
Jason Garland
executiveYes. It's value the same point in Repligen, we've been focused on that growth. Unfortunately, through my years, I've spent a fair amount of time on maybe the lower -- the slower growers and a bit more of running the cost sort of play. And so what I've been able to do is bring a few things on my playbook of have we thought about this, whether it's sourcing, in-sourcing, right? Those are places that again, you can get some really good wins and bringing in processes. I think the biggest thing that I'm trying to do is give the team visibility at a different level of our financial performance on our profitability and our cost structure. And that to me -- I don't know that it's low-hanging fruit, but it's an important fruit to get. And we're making a lot of great progress there. Because you -- in order to take the right decisions, you have to have visibility, you have to have a measurement system around that, and that's really where I've been focused.
Conor Noel McNamara
analystOkay. Great. Thank you for that. And then if you look at your revenue exposure, obviously, there's been -- the mAbs have been a big contributor. And you've talked a little bit about some of the cell therapy and gene therapy opportunities out there. Just can you give kind of your revenue exposure to each therapeutic class and how that's expected to change over time?
Jason Garland
executiveYes. So we're still 80% mAbs. We're about 20% in what we call the -- our new modalities. So that would be inclusive of cell and gene therapy, mRNA. I'd say the gene therapy side is probably half of that 20%, the mRNA is 30% of that. But the way we think about that new modality space is really the focus on our top 20 to 25 customers that are over $1 million of revenue for us. And that's where we've been really focused on helping them grow, helping them work through the stages either through clinical or up from Phase I, II to III. That's really where you see your pickup in terms of growth for us, but obviously, then the company is getting closer to that commercial stage. But so that's where we'll continue to focus. I think we bring a lot of great solutions to the space. And again, in the context of better yields and more efficiency and there's a high interest. And I think, again, where we play best is entering into that clinical sort of basis and then being able to grow with them through as they progress.
Conor Noel McNamara
analystRight. So if you just look at the total number of programs, I understand from a revenue perspective, mAbs has a higher percentage. But from a program -- absolute programs and revenue opportunity. So if you look at the company in 5, 10 years, do you think it will be shifted to some of these new modalities?
Jason Garland
executiveYes. I don't know if we shared the total number of programs. But absolutely, we see that mix changing, right? So we were -- I think we said we were 15%. Was it 2 years ago?
Steven Chehames
executiveYes, it was in that 14% to 15%, went to 18% last year and then implied guidance for this year about 20%.
Jason Garland
executiveSo we'll keep growing that mix of the cell and gene therapy. Again, we think we -- our products fit that -- fit well. But in terms of pure number of programs. I don't think we've shared that.
Conor Noel McNamara
analystOkay. But typically, there's a revenue step-up for you guys maybe 3x to 5x from Phase I to Phase II, Phase II to Phase III.
Jason Garland
executiveAbsolutely. And then even more into that commercial space.
Conor Noel McNamara
analystOkay. So just even without winning new business in those new modalities, you see some growth -- pretty good growth opportunities?
Jason Garland
executiveYes, because the other -- if you look at the company overall, we're still 65% clinical, 35% commercial. So again, you get some inherent tailwind as you move along through the stages or phases. And certainly, some things will fall out, right? But if you have enough swings, right, you're going to get a lot of great hits through that progression.
Conor Noel McNamara
analystAnd I think it was 9 programs in 2023, late-stage programs that you guys brought on board. Just what's -- how do we think about the revenue opportunity there? And when you say late-stage opportunity, I was under the impression that a lot of this gets spec-ed in early on in a clinical trial. So how are you able to come in and win that business?
Jason Garland
executiveYes. So yes, so we talked about 9 programs in our -- with our ATF portfolio specifically. If you think about if it's commercial, because we said it's 9 late-stage and commercial. That's where if you have a next gen, right, or a biosimilar sort of next-gen process, that's where you can come in, to your point, if it's an ongoing production that's not an easy entree. And then on the clinical piece, companies can still make decisions certainly in late-stage Phase II or even into Phase III to bring in our product, especially when it comes to the ATF side where really -- that's really all about faster production, higher yield. So again, as a customer, we see all right now as I'm progressing, what do I need to do to improve my overall efficiency on this product. That's where an ATF can come in and help them and improve. And so again, getting in kind of to your point, kind of just at the last minute, it works and then we can be spec-ed in and then it would grow into the commercial side.
Conor Noel McNamara
analystAnd do you ever get -- so on the new modalities, things like gene therapy and cell therapy, do you get spec-ed in earlier than that? Or is there -- is it kind of up for grabs once we get...
Jason Garland
executiveYes, I mean, I think a lot of times, customers may be looking at different products and different processes and that's certainly in the early stages to figure out what's going to be best for them. To spec in probably is probably a stretch in the term, right? We wouldn't necessarily be "spec-ed" in yet, but we're a part of that development. And then it's through what we're demonstrating and the value we can bring, then it allows us to move on to that Phase II and then at some point then being spec-ed in. You got to be a part of the early trials to demonstrate the value you can bring.
Conor Noel McNamara
analystDoes that give you pricing power because you're already in there? And when do those pricing conversations start? Is that in the preclinical? Or is it when you kind of get to that next phase?
Jason Garland
executiveLook, I think in any sort of ramp up, there's always an implied volume price correlation, right? So I think the dialogue is more about not -- okay, if we're spec-ed in, here's where you're at, but how do you see volume growing and with volume growth, and we're able to provide better pricing or maybe more discount, if you will, off of the list prices that we have. But again, we're going to price it in a way that's attractive for them to trial, right, and bring our process in. We're going to say, hey, it's a small run as you go through the phases, prices accordingly and then with the idea that at a commercial level, the volume is going to be a different game.
Conor Noel McNamara
analystGreat. Now just getting to Q1 and guidance for the year. There's -- the book-to-bill has been talked about a lot the last 5 quarters, and I think you probably before that, you guys weren't asked about book-to-bill in 6 years or 10 years. So just walk me through what gives you confidence there's a small step down in book-to-bill. And should we be concerned about maybe that means there's some softness? But at the same time, you've got a lot going on between the proteins business rolling off and then you've got the COVID business no longer there. So just what should we think about from that book-to-bill? And what gives you confidence in hitting numbers this year?
Jason Garland
executiveYes. I mean we were sharing with some of the earlier discussions this morning. I mean, we're like 0.993 or something. So like we are so close to being able to round to 1. We're like, well, okay, to us, a point where we were at 0.99 was the same as 1, and that's why we were thinking about really the first half, and then we shared that for the first last 9 months were 1.03. I think that -- all that said, I mean, really, it's book-to-bill as your orders -- as you guys know, orders to your revenue, the way for a higher book-to-bill could have been to have lower revenue in the first quarter, right? So -- and we're only sequentially versus fourth quarter, we were down about 3%. And orders, if you take out really proteins, we are flat. And so for us, I thought we were comfortable with where we landed. Again, a 0.99 versus 1. And I know that, that -- there was a lot of reaction to that and that small difference. But I think for us now, it's about do we have the orders and trajectory on the orders in order to deliver the revenue guidance that we've shared for the first half. We've talked about 300 to 310. So that implies, call it, some around at a mid point, call it, 150, 455 for sales in the second quarter right? So it certainly as where we stand today, we have line of sight. And then really now, it's the next few months of taking orders in, in order to have to deliver the second half. And where that book-to-bill now lands for the second quarter and the third is less about the book-to-bill and more about the absolute orders that we have and the backlog we're filling. So look, we continue to push commercially with our customers. And -- but it will be a mix of what we can deliver as well as just that overall market demand.
Conor Noel McNamara
analystAnd the headwind from the protein side, can you just walk us through the absolute number? And why is that there? And should we have confidence that that's not going to be a headwind beyond this?
Jason Garland
executiveYes. It's a great question. And I think it's for us, it's fairly unique to Repligen as well as a 2024 headwind. And so there's really 3 pieces to it. We talked about the Cytiva business that we've been a big part of the partner with them for years and years. They've also been in-sourcing over the last several years. That finally has now reached a point where anything we sell to them is de minimis, but we still had $10 million of revenue in 2023. So that -- so again, as you go into '25, not a headwind. The other piece of proteins is there was one of our partners did announce the discontinuation of a couple of other products that we support. And so those -- those move out. Again, we don't see that as a headwind. We're not aware of any other major discontinuations. And then the third piece is one of our key partners that we've really putting our efforts into growth with frankly, I think, built up more inventory in 2023 than they had expected. And so that's now -- it's kind of another form of destocking. It's not the famous COVID destocking, if you will, but an element of that. And again, they have line of sight to get through that inventory in '24. So then as we go into '25, we put behind -- there's no more Cytiva headwind -- the discontinuation is over and we're back to growth. And that's why we've talked about being back to double-digit growth on the proteins franchise in 2025.
Conor Noel McNamara
analystGreat. And can you just -- any update on China? That's -- you've got -- you're really strong in the first half of 2023 from a sales perspective. So you've still got another quarter of comps. But is there any movement there? Anything that you've seen out of China that gives you confidence in a rebound in that?
Jason Garland
executiveYes. Look, we will be -- China will be about 5% of our sales in 2024. It was 7% last year, right? I think our view is that, that it's sort of bottomed out, if you will, in '24. I don't know that we are bullish yet next year. But I think the headwind that we've seen this year going from 7% to 5%. Certainly, it's is less of 1 in '25. I think there's still a lot of shaking out on biosecure. I don't know if everyone heard too, but this morning, he talked about now grandfathering things into 2032. So again, more time for company that's the latest proposal that's being voted on. So more time for companies to sort through that. We also, again, have the advantage that if we're in the process, even if the production leaves China and ends up in another country, another company, we'll still likely follow within the production side. So right now, our view is that there's still going to be long-term opportunity, but whether that shakes out much in '25. Right now, we wouldn't be basing a lot of growth in our outlook for 2025.
Conor Noel McNamara
analystGreat. With just over 5 minutes this is a chance. I don't know if you weren't here last year, but I'd like to have a little bit of fun with you guys. And so for the last 5 minutes, I'm going to test your problem solving skills, your ability to multi-talent -- is under pressure. So you get to work on this rubric cue while I continue to ask you questions you could finish that 5 minutes.
Jason Garland
executiveThis is -- so my days in the '80s.
Conor Noel McNamara
analystSo let's see how far you get in 5 minutes good. And so now the most common question I get about Repligen is why are -- how is Repligen able to grow so much faster than the bioproduction market?
Jason Garland
executiveYes. It's a speed of innovation, right? I mean it's back to what you asked me why did I come to Repligen? It's that ability to be scrappy to focus and prioritize innovation. And that allows us to get new products out, again, demonstrate benefit. I'm not finding a good side here to actually get done here.
Conor Noel McNamara
analystBut the leadership skills, the ability to delegate.
Jason Garland
executiveThat's agreed. But that innovation cycle, again, gives us room to grow faster than the market. And frankly, which, again, at the end of the day, is taking share by bringing -- by again, that higher efficiency, higher yield that we can help for our customers through innovation.
Conor Noel McNamara
analystFigured out. Making some progress over there. Capital deployment over the next near- and medium-term, you guys have a clean cash position, how much M&A is required? And it sounds like you guys are in good shape as far as capacity build out. So how should we think about capital deployment?
Jason Garland
executiveYes. Look, the M&A strategy teams executed the last several years is -- has been amazing. And I think the one thing, again, as a new set of eyes to the company is I think Repligen is second to none on the way we integrate the technology within the products of the companies that become a part of the family. And even as I've talked with Tony, the discipline on ensuring that we can bring value to a company, versus all right, it's a high grower, it's accretive to margin, let's buy it and it's a no, what can we do to help it grow and -- or help it integrate with our products. And so that is our focus. We're still very active. We have an active pipeline and always interested to see. But we're not going to settle. I think to that point about discipline, we're not going to settle for something shiny new. We're going to continue to look for the right companies that can be a part of the portfolio. And we have the balance sheet to execute a lot of that, especially the tuck-in sort of bolt-on size companies that we've done.
Conor Noel McNamara
analystAnd on pricing, you guys took -- obviously, during the pandemic, there's a lot of pricing that you guys were able to take. Yes, how you doing over there, Steven. So where does pricing stand now? How are your customers willing to give price? And how should we think about price this year?
Jason Garland
executiveSo we've shared that we're assuming flat price for 2024. What that really means is a lot of ups and downs within the portfolio and with our customer base. So there's certainly be products that are up, others that will be down. We did increase our prices, our price list and sort of pricing at the end of the year. Some of that will fall through. But we've also been, I'll say, prudent in that as we continue to build out on our key account strategy, right? We recognize that to move the needle on growth for us. We need to be partnered with the big players in the industry and we've added a new commercial team, brought in experienced leaders in that space. Oftentimes, that will come at the cost of more volume for lower price. And so that's why especially also in an environment where the market is still, I'll say, recovering or stabilizing that, that now is not the time to go out and be super aggressive on pricing. So that's why we've taken a prudent view of flat overall. But we certainly will be achieving prices in some places.
Conor Noel McNamara
analystAnd then you mentioned some of the key accounts. If you look at the new modalities versus the mAbs, is there an opportunity for more bundling? Or are those modalities going to require more products from you guys? Or are they going to look to more vendors? And how important is the ability to bundle and offer kind of the complete bio production line on some of those modalities?
Jason Garland
executiveYes, I think one of the things that -- one of the biggest tailwinds of COVID from Repligen was just demonstrating how we could supply in that space, particularly mRNA and that what we can bring to advantage. And so it's that demonstration plus the relationships we have with big players on the mAb space that give us the credibility to say, okay, you're entering in new modalities, we can be a part of that and can help you. And so that relationship and credibility and demonstration of what we've done really forms the foundation of that.
Conor Noel McNamara
analystGreat. I think that brings us to the end of our time, Steven...
Jason Garland
executiveSteven, you got anything? Not even a side?
Conor Noel McNamara
analystHe didn't even finished a side. Well, I think guys are going to work on that. But thanks for your time. We appreciate having you guys here.
Jason Garland
executiveAll right. Thanks a lot. Thanks, everyone.
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