SkinBioTherapeutics plc (5KW.F) Earnings Call Transcript & Summary
April 16, 2025
Earnings Call Speaker Segments
Operator
operatorGood morning, ladies and gentlemen. Welcome to the SkinBioTherapeutics plc investor presentation. [Operator Instructions] The company may not be in a position to answer every question it receives during the meeting itself. The company can review all questions received today and will cover the responses where it's appropriate to do so on the Investor Meet Company platform. And before we begin, we would just like to submit the following poll. And if you'd give that your kind attention. I'm sure the company would be most grateful. And I would now like to hand you over to the executive management team from SkinBioTherapeutics plc. Stuart.
Stuart Ashman
executiveGood morning. Thank you, Jake. Good morning all. Thank you for taking the time to join us. We just walk through the disclaimer slides, please Jake, and the next one. We're going to be walking through our interim results, which run us through to the end of December of last year and give you a little bit of a forward glance of what's happened post period. So we'll be walking through the operational and financial highlights, our strategy for the year through to the end of December and our strategy for the coming year. We will give an operational review on our platform businesses, the Biotix-Ps and also on the acquired businesses, both Dermatonics and Bio-Tech solutions. We'll then walk through the interim financial review for '24, '25 and then finish off with some outlook and guidance for the rest of this year and then with some concluding comments. So in summary, for those of you who don't know us, we are a proprietary SkinBiotix technology business, which we look at skin barrier repair. We originated from the University of Manchester, and we IPO-ed about 9 years ago. The Board and the management team and those that we have acquired in the last 12 to 18 months have deep med tech skin care and financial experience in this sector. We tend to target multibillion pound markets through multinationals in skin care, looking at the treatment of skin conditions and irritiable conditions like psoriasis, acne, but also foot care and the cosmetic industries too and we do that from in-house development and also now with bolt-on acquisitions. In terms of our development and commercialization partners and we're delighted to announce that we've now launched with Croda Plc, and there'll be a lot more detail on that particular product and Zenakine later on in the presentation. We get our food supplements in conjunction with Windfall BB in the Netherlands, and we sell those products to Amazon and World products, and we also have a commercial tie with the Umesh Modi group in India. We have sales operations and distributions now worldwide, and our R&D programs continue in the oral cavity area and inflammation and also in advanced probiotic food supplements and which is now moving into eczema and rosacea, now that we've completed psoriasis and acne, and we exploit those 2 external licensing opportunities. From 2022, we executed the dual strategy, not knowing what the outcome would be of the clinical trial and not wishing to bet everything on that 1 single strategy. We implemented a second-tier strategy to accelerate scale and reach profitability quicker through not just internal product development, but also a mergers and acquisition program and which is now well known, and we will report on the progress there. The '24 '25 pro forma financial post synergy on an annualized basis with Ce Group revenues at GBP 6.3 million with each consolidated EBITDA of GBP 2.2 million. And then the analyst guidance on that, given that we did not have Bio-Tech Solutions advantage for the full year, we didn't acquire that business until October of 2024. The consolidated revenues of GBP 5.3 million and consolidated EBITDA loss of GBP 900,000. So in terms of our applications, those of you who know us, this will be old news, but we have external applications initially, our proprietary cornerstone technology using ligated bacteria. That's backed up by a very strong IP portfolio, which is registered globally. We have an active cosmetic program with Croda, which generated revenues in 2024 and initial revenues and is now launched on a global stage. We have our applications in this particular sector in cosmetics, skin care and also potential in professional cleaning sectors. From an internal perspective, we have complex probiotic blends food supplements that target the gut-skin axis. We launched AxisBiotix for psoriasis in 2022. We continue to have high retention rates and more about that later. We continue our discussions with high street retail chains and multinationals to further expand this. And we completed our acne study last year, and we move towards commercialization, and I will detail that in just a moment. So in summary, we've made excellent progress in the Biotix pillars of our platform technology. SkinBiotix was launched by Croda last week in Amsterdam at the -- in Cosmetics show that product, as we now know, is called Zenakine, and I'm going to have Dr. Surinder Chahal walk you through a very technical presentation that was given by Croda at that presentation so that you can see what all the hype is about from this extraordinary product. Furthermore, AxisBiotix expanded our B2C offering in psoriasis and the acne product is now prepared for launch. We also have National Psoriasis Foundation approval, and we're now waiting for the documentation to come [through] on that particular roosett of approval so that we can put that on our packaging. And our R&D pipelines are progressing very well. Furthermore, we moved on, we completed 2 inorganic acquisitions, Thermaltronics, which was completed in January 2024. That integration is now complete and progressing extremely strongly in all areas and all sectors. Biotech Solutions was our second acquisition, which was post year-end, and that was completed in October of 2024. That provides manufacturing as well as the sales of products that provides manufacturing capability. That company now manufactures many of the product or most of the products that Dermatonics were buying in from a third party prior to our acquisition. That's given us significant strength in foundations. It's also strengthened our people. We acquired some excellent assets. We've got some great management both in operations and in sales and marketing and in the finance functions as well. We also had an additional rather unexpected capital raise in August of last year, where we were approached directly. We did not go to the road on a road show that the investors actually approached us. As a result of all of that, we have absolutely 0 cash concerns whatsoever, and Manprit will go into that in some detail throughout the presentation.
Manprit Randhawa
executiveSo in terms of financial highlights for our half year to December 2024 results, which we reported in late March, revenues came in at a little under GBP 1.6 million against a prior period comparison of GBP 110,000. That's largely due to uplift in sales of the AxisBiotix psoriasis product, but we've also got a full 6 months of Dermatonics revenues in there and then 2.5 months of Biotech Solutions post acquisition. Operating losses and net losses importantly reduced from prior year, and that's largely due to the accretive nature of both of the acquisitions and their profit-generating operations. In terms of cash at the end of December 2024, we were at GBP 1.24 million against the year-end balance of GBP 0.8 million. This largely reflects the input of the fundraise in August 2024 when we raised GBP 1.8 million of gross proceeds. So, on a pro forma basis, as Stuart mentioned, had we had both Thermaltronics and Biotech solutions from the 1st of July 2024 and execute those synergies on day 1, we would be at GBP 6.3 million of revenues and past EBITDA breakeven. Our cash runway on the core business, as we stand today, excluding Croda revenues, we expect to last through to summer 2026. And to reiterate, we do not have any cash concerns.
Stuart Ashman
executiveSo I thought it was important to put this slide up just to demonstrate to those of you who've not seen this previously, how lengthy a journey we've had with Croda and how complex this project was. I think it's really important to understand that since signing that contract in November of 2019, every single box that has a red outline was a go, no-go stage phase and any stage during this project where these boxes indicate on that time line, we could have come to a grinding halt and had to basically execute another strategy. So the replication of the lysate in July 2020, extremely precarious. And again, this was binary. It was a go, no-go. If they could not have replicated that, we would not have had a project to run at. Again, with the mapping and selectivity the following year in September, that again was a very, very complex piece of science as was the downstream processing. in June of 2022 and the scale-up in January of 2023. Had we not seen that herding of bacteria, had we not seen that additional activity, we would not have gone on to the extension and the clinicals. Had we seen a downturn in the bacterial activity on scale up, this contract would have come to an end. As it turned out, that extension was granted and the clinical started. Now the clinicals, we always said were not -- it was not going to be a binary outcome. It was not a go, no go. That's why that has an amber box around it. This was very much along the lines of will we sell it at a higher price or a lower price. Those clinicals completed in June 2024, and the readout was issued in September of 2024, the same year positive clinical report. We then basically quota then sent out additional samples issued and then the marketing commenced in earnest. In October/November of last year, we reached a final commercial agreement. Again, we may well not have come to terms on that and the IP was then filed and it could have been objected to. That didn't happen, and we passed that go, no-go and successfully concluded the launch of this product last Tuesday in Amsterdam. I think I put that slide up to demonstrate why we set out on a dual strategy, why we set out on a mergers and acquisition quest and why we bought 2 strategically valuable and accretive companies that would complement our strategic offering that were sector-specific. We executed that in 2024 because we didn't know the outcome of the clinical trials, and we didn't know how fast this would roll out. As it happens, it was very successful indeed. Next slide, please, Jake. I'm going to present now -- I'm going to play a video that we prerecorded with Dr. Surinder Chahal. For those of you who don't know Dr. Chahal, there is nobody better to walk us through the technical benefits of the product that's just been launched, which we now know is Zenakine. Dr. Surinder Chahal's signature sits next to mine on the contract that was exercised and executed in November of 2019. He is [indiscernible] and intricately involved in this project from day 1. He's previously the Head of R&D or the Vice President of Long-term Innovation for Personal Care Product, prior to which he was Head of Customer Alliances and Technology. He has been with Croda for 37 years. He was with us at the trade show, at the launch in Amsterdam, and he has been the teeth in our negotiations in November -- October, November and December of last year with Croda to get the contract signed. Next slide, please, Jake. So I'd just like to introduce to you Dr. Surinder Chahal. And for those of you who haven't met before, Surinder, if you could just give a brief introduction before we go into the presentation.
Surinder Chahal
attendeeYes. Thank you, Stuart. My name is Surinder Chahal. My background has been working for Croda International plc for 37 years in a R&D function. Most recently at Croda, I was Head of Global R&D for the Personal Care business. And my final role was as a VP, Customer Alliances, long-term innovation, working with the large multinationals on new strategic innovations. I retired from Croda last June, and I'm currently a strategic adviser for Skin Biotherapeutics plc.
Stuart Ashman
executiveThank you. And earlier this week, we had the pleasure of attending the in-cosmetics show in Amsterdam, along with Dr. Cathy Prescott, who is a Senior Nonexecutive adviser to the Board. And we witnessed the launch of our technology, our proprietary technology, which we've developed in conjunction with Croda Beauty and specifically Sederma in Paris, at which they gave a very detailed technical presentation that tells some surprises for us all. So we thought it might be a good idea to walk you through what is quite a lengthy and quite a technical deck. So I'm very grateful that I have Surinder with us here to walk through the nuances of some of this. So we'll put the deck up now. So the name of the product has been now revealed as Azenchene. And it began with a very much a sensory introduction, which we won't put you through. Everyone closing their eyes and thinking about well-being and the tightness of their skin or not as the case may be. And then sort of moved on to the content of the presentation, which is the content and market needs -- a background to what the market requires and what demand is for, then some comments on neuro cosmetic performance and then skin cell clonal biology and then the features and the formulations of the product. So yes, I began with a sort of insight setting out chronic stress, aging and well-being. We all were expecting some anti-aging content in this and some increased hydration, et cetera. But then going on to talk about complex things like gut to skin brain communication. So can we start with Slide 5 here...
Surinder Chahal
attendeeYes. I can give a little bit of introduction. So the first few slides, as you say, I'm basically talking about the general understanding of stress and our stress can relate to premature aging, particularly in skin and many other neurological disorders as well that are related to stress. So again, this slide basically talks about the consequences of stress and how we've seen more and more people developing situations of stress, particularly since COVID, and we've certainly seen that here in the U.K. with a very large number of people out with stress-related concerns. So Zenakine, which we were introduced to just this week, a postbiotic neurocosmetic. Basically, it's postbiotic means it's metabolites that are either secreted or recovered by lysing of vacillus. And in this case, it was a Lactobacillus rhamnosus GG. It also tells us that around the world, people are very concerned with stress and how it impacts them and their lifestyle. This slide just gives an indication of what Lactobacillus rhamnosus GG can help with, it can help with neural and humoral immune systems and concerns in the body. there's a lot of information on this [indiscernible] from a food-related application as well as its application in the gut-skin axis. So that's very much this slide. The next one talks about information again in the public domain talks about the skin biological clock circadian rhythm. Our skin clock is important, maintaining that skin circadian rhythm is important to good health and also to good neurological health. And skin chrono biology is important for skin protection for skin hydration, skin production and the other elements that you can see on this slide. And skin chrono biology is important. It's related to a number of genes, period genes. It's also related to melatonin and melatonin is very important and oxytocin. These are these positive hormones that we require. And these are generated during nighttime and then daytime, there's regeneration of the skin, which is important. There are various factors that are involved and components involved with the regeneration. And we'll talk a little bit more about that as we go through the slides. There are a number of study protocols that Croda Beauty adopted, some were in vitro and ex vivo and also the clinical trials, which was in vivo studies. And there's a list of the in vivo studies on the right there that were carried out. So firstly, we could talk about neuro benefits and the clinical performance of Zenakine on sleep and well-being and skin stressed [acne]. So Slide 12, 3 complementary clinical studies are done, expression of wrinkles, stress fatigue and sleep issues were looked at and skin firmness was also considered. Now this slide just basically tells us that Zenakine formulation was delivered from a formulation and the formulation was compared to a placebo. And the 2, the placebo and -- the placebo containing the Zenakine were looked at for a sensory benefit or sensory changes. And basically, what they found was there was no difference between the placebo and the placebo plus Zenakine formulations from a sensory benefit. So sensory had nothing to do with the benefits that we will be talking about going forward. They found that there was an instant trigger, immediate relaxation and this was work done using electro and [indiscernible] -- and basically, immediate treatment of this Zenakine formulation on the skin induced a feeling of relaxation and calmness compared to the placebo. And that was quite surprising because it acted immediately. So that was first part of the clinical trial, number of volunteers used and the age group can be seen and it's described in this slide. So Zenakine instantly improves our benefit. There was a wellness increase. So over time, Zentyal induces a number of positive emotions, a feeling of happiness, emotional balance and self-control and this was important, as you can see there. So these were questionnaires that were looked at and the volunteers were asked and there was not much more to be said. So there was a good improvement there. sleep improvement. Again, Zentyal promotes restorative sleep after only 2 weeks of use. As can be seen on the right there, Tzield compared after 2 weeks and after 1 month. And this is sleep tracking that was carried out at an external group in France, a group that is used by clinicians to monitor sleep. So the study was done there. And [Zenakine] basically promotes restorative sleep after 2 weeks and gets better after 4 weeks. So that's an important finding for this product.
Stuart Ashman
executiveAnd, in fact unexpected by all of us.
Surinder Chahal
attendeeAbsolutely. Yes, absolutely. This is quite new and novel. And skin resilience, obviously, looking at wrinkle. So this basically is demonstrating that the application of Zenakine again on volunteers of that clinical study over a period of time, you can see that there's wrinkle reduction. So this is actually having a physical effect on the skin as well. So skin, it reduce the stress in skin and that will help reduce wrinkling. So this residual tension that is seen on the forehead, skin is regenerated and you get a reduction in the expression of wrinkles, as you can see in the images there, [Tzield] and after 1 month on the right and the placebo is on the top and the images below demonstrate the reduction in wrinkle -- wrinkles in the skin. And then moving on to chronobiology, the circadian rhythms, the biological mechanisms associated with biological clock and the improvement of cell longevity and skin regeneration. So one important element of the use of Zenakine is that it tremendously -- it massively increased melatonin production in both fibroblast and in keratinocytes. And this was very important and melatonin is important very much so. It's a potent antioxidant and it also modulates the circadian rhythm in the cell. So again, as you can see in the slide -- in the graph at the right, there was a huge increase both in fibroblast and in keratinocytes after the application of Zenakine concentrations there. And also when it comes to the circadian rhythm, there are certain genes, what we call period 1 and 2 genes that regulates cell cycle in skin regeneration and another gene CRY2, which regulates both period genes and ensures the circadian rhythm is maintained throughout the day. Now what can happen is when we're stressed, you generate high levels of cortisol. And cortisol triggers over-expression of the period 1 and 2 genes and therefore, disrupts the CRY2 gene oscillation. The application of zenakine in the presence of cortisol downregulates the period 1 and 2 genes and restores back the circadian rhythm of healthy skin. And that's what the graph on the right demonstrates. Once you treat -- when you treat with cortisol, you see that disruption. But when you add Zenakine into [indiscernible] the cortisol in the client, you recover that circadian rhythm, which is important. And also cell energy. So what happens is that with Zenakine application, there are certain coenzymes that are promoted. The promotion of these enzymes increases mitochondrial energy production in keratinocytes and that's necessary for cell renewal and metabolism. So basically, Zenakine increases NAD and NADH production, which in turns boosts energy production, which in turn increases cell renewal and metabolism. And another gene, it's a 3 in 1 -- it's is a longevity gene, and that plays a crucial role in the amplitude and duration of the circadian rhythm in keratinocytes. So what we found here was that by enhancing NAD, the previous slide we talked about in keratinocytes, [Zenakine] can also stimulate an expression of this 3-in-1 gene and that contributes to skin homeostasis, i.e. maintaining a good balance of temperature and also barrier integrity, which is important for skin health. Talking about barrier. Again, Zenakine improves and promotes skin barrier formation by enhancing a couple of other proteins, FOX-N1 and ROR alpha. And these are promoted and these as a consequence of being promoted helps the skin barrier formation, again, fighting against cortisol-induced premature agents. So again, cortisol was used here, but then Zenakine was added to the cortisol, and we can see a massive improvement in the expression of these proteins. And a very busy slide here. It talks about the epidermis and reinforcement of the epidermis, which is important for skin health. There are a number of components involved in the epidermis and those are mentioned there on the left, the [indiscernible], the Langerhans, [indiscernible] 1 hyaluronic acid. And one important element there -- a component there is Z01, which is a junction protein that controls permeability and prevents water loss, and that's an important part of the skin. And again, we find if you look on the right and the images below, you get a recovery of that particular component in the skin, especially when you compare it with cortisol. So cortisol you see a down regulation, but in the presence of Zenakine, you get that improvement. And also the graph above, it looks at the other components in the skin as well, and you can see a positive progression there for both materials.
Stuart Ashman
executiveAnd Z01, I know a lot of -- we've had a lot of questions about whatever happened to us addressing hydration and tight junctions, and that's exactly what you've just spoken to, yes.
Surinder Chahal
attendeeYes, absolutely. And that's important. And there are other actives as well that can do that. But what we're seeing with Zenakine is that it's got multiple other properties which other materials wouldn't represent or present.
Stuart Ashman
executiveSo it's a bit of a swiss army knife...
Surinder Chahal
attendeeAbsolutely. And again, this was something that just talked about endorphins, oxytocin, dopamine and beta endorphins. They're neuro-transmitted related to melatonin synthesis and they contribute to the stress response and cell regeneration. And what we found again or what found was that and the high levels of cortisol when the skin and the body is under stress, Zenakine stimulates the production of these field good messengers, the oxytocin dopamine and the endorphins and that helps avoid stress-induced premature aging and a little description there on the right. So in the presence of Zenakine, you get that positive development there. And very importantly as well, skin matrix generation. So the physical benefits of the use of Zenakine and it promotes the synthesis and matrix -- skin matrix components, stimulating skin regeneration. So they found that collagen 1, which was increased by 36%, collagen 4 by 67%, fibronectin by 20% -- these are massive numbers and [indiscernible] by 26%. So that all goes very, very positive to skin health, skin antiaging, anti wrinkle. So that was very important finding for them as well. Finally, moving on to [indiscernible] applications, looking at our products, some of the formulations, and we can do that in the next few slides. So the actual product, which has [indiscernible] name, which you can see [indiscernible] and it's supplied in the presence of some glycerin [indiscernible] glycol [indiscernible], and that's just to maintain stability of the material as supplied. It's got a high biodegradability score, 100%, which is brilliant, okay? So it's not going to persist in the environment. It's 100% natural origin, meets a number of standards. And the recommended use level, as you've seen in most of the slides we presented today is 3% of supply. It has a very high sustainability score, which is important for many of Croda Beauty's customers. Certainly, a lot of the multinationals are very reliant on materials having a high corporate social responsibility score. And Zenakine has that. It's an excellent score there. So that's a very positive thing as well.
Stuart Ashman
executiveIt's your selling point?
Surinder Chahal
attendeeYes. And formulation guidelines, it's easy to formulate. It's water soluble. It gives you a little recommendation of PH to use, which is kind of standard the kind of scheme pH 5 to 7. And if you want to add some telling agents to give some rheology to the materials and some [drilling] agents are recommended there as well. And it can process at room temperature up to 45 degrees, which is great. So you can cold formulate this. And that's just something that's quite interesting. So we talked about it earlier this week. So they've all created a number of formulations, but here's an example of formulations where they've also used interesting fragrances. Now fragrances on their own can also induce a neurological effect and emotion. And so they've chosen certain fragrances here that can enhance that perception of well-being of anti-stress and Tranquility. So we've known this for a while, that fragrances are very important. You can have exactly the same formulation with the same benefits with 2 different fragrances and people will always pick the fragrance as a product that they feel provides a neurological preference. And so here, they've created a number of formulations with different fragrances or with strange names like I love you very much and on Cloud 9. And those fragrances will help enhance that immediate perception that consumers see, which is good.
Stuart Ashman
executiveExcellent. at this stage, the technical presentation ended. I must add that this was presented to a packed auditorium standing room only. We arrived -- the 3 of us arrived 15, 20 minutes early, and we're lucky to get a seat within minutes of -- prior to the presentation starting, there was, as I said, standing room only. And it was concluded to a bit of a standing ovation. So an outstanding technical presentation for what looks like an outstanding product. We were not expecting an awful lot of those attributes. And I think we afterwards sort of went back to the [indiscernible] and there was an enormous amount of interest. There was a lot of people on it. The buzz was very much about Zenakine. And I think there was a couple of interesting comments. Some of the amusing ones that came through our persistent investors and bulletin boards were is this just the next generation of Horlicks, which we all found highly amusing. So whoever it was that made that statement, you gave a lot of people a great needed sense of humor that [indiscernible] and a bit of a giggle. I think it's important to point out that we were at a cosmetic ingredient show. There was -- what do we say? Did we say there was in excess of 1,000 exhibitors?
Unknown Executive
executiveAbsolutely, yes.
Stuart Ashman
executiveYes. And Dr. Chao was explaining to us this over the course of the last 30 years, that number has grown immensely. It's 10x the size of the show that it once was -- an enormous show in line with the medics, et cetera, that go on around the world. I think it was described as Horlicks and Croda were focusing on the sleep element early on because it is a given that the cosmetic ingredient show that this has cosmetic benefits and I think you've just demonstrated through the slide that the tight junctions, the increased hydration, the anti-aging elements, the well-being elements, they were all the cosmetic elements were all to be expected, what we hope for. The additional well-being, increased melatonin, reduction in stress, all of those sorts of things are so much more than we were anticipating. And I spoke to a couple of the technical people that gave it to me very much in layman's terms to say that you have when you're painting, which I don't, you have primary colors. And if you want to create pink, you add red and you add white and the more white you add the lighter shade of pink, the more red you add the darker shade of pink, likewise, with gray with black and white. So what we've effectively got here is a new primary color that's something that we can add to just about any [indiscernible] the darker shade of [pink] likewise with gray with black and white what we effectively got here is a new primary color that's something that we can add to just about anything. And when our customers come to us and say, this is the end result that we'd like, Zenakine ticks multiple boxes here. And I think the cream of the crop being is it's 100% natural.
Surinder Chahal
attendeeYes. You're absolutely right, Stuart. And one of the things in relation to this product, maybe I mentioned this in the past that the cosmetic industry is built around emotions and -- emotions and emotive products now, people feel good about themselves, and that's important. In this case, with Zenakine, they've been able to quantify and measure those emotional benefits. And that's the first emotional products sell. And when we buy, we smell things. We prefer the better smelling things. There's something called the lipstick effect. So I may have not mentioned this in the past, but during the period when there was financial issues and I think going back to 2008 when the share -- the markets collapsed and everybody was in [indiscernible] phase and the people are not feeling very well about themselves. But what happened when the markets went down is that lipstick sales actually went up. And that's because when we're feeling down, we want to feel better by applying cosmetics and just basically wanting to feel better mentally. And cosmetics have a part to play there. In the case of Zenakine, all that stress alleviation is measurable. But on top of that, you've got the physical benefits in the skin as well. So barrier integrity, collagen formation, anti-wrinkle, anti-aging. So it's a unique product in that sense. And the maximum value is where you've got that both the functional benefits that are measurable, the story, which is very important, but the story and the product that is perceivable by the consumer, and that's been the case here.
Stuart Ashman
executiveExcellent. I think the final comment that one of the marketing ladies said at the back end of the show was it's almost created its own category here. And we were bouncing around that phrase. It's a bit of a Swiss Army knife. And I guess it does bring total new meaning to the phrase beauty sleep. People use that phrase a lot. I need to get some beauty sleep and this absolutely delivers exactly that. So we've got a groundbreaking sort of global launch of a category creating Swiss Army knife that makes you look good, feel good and sleep better.
Surinder Chahal
attendeeSo it functions during the night, pretty sleep and it also functions for skin regeneration during the day.
Stuart Ashman
executiveAnd I think the other thing we said is the longer you use it, the better it gets.
Surinder Chahal
attendeeYes. Yes.
Stuart Ashman
executiveAnd we've proven that, yes. Dr. Surinder Chahal, thank you, first of all, for your presence at the show and your company, and thank you also for explaining this to our shareholders invaluable. Thank you very much indeed.
Surinder Chahal
attendeePleasure. Thank you.
Stuart Ashman
executiveThank you, so that was a very lengthy technical summary. We thought it very important that you see every slide that we saw have that explained by somebody who is uniquely qualified to explain quite how extraordinary a product this is. As we said, it was an outstanding reception. It was by far the busiest auditorium in terms of the technical presentation. We had all of the expected cosmetic attributes and there's many people on the boards I led to believe that have been saying, well, it just enhances sleep, and that's absolute nonsense. I think you've just seen the clinical evidence that shows that this enhances the skin's natural barrier, restores elasticity, has all of the anti aging, the attributes that we look for in closing junctions, all of the increased hydration. And then on top of all of that, it increases melatonin, advances it gets advanced prepared whilst you sleep and it increases your sleep quality and reduces stress. As we said during that talk and as Croda said themselves, this product, this ingredient has created its own category. It is quite literally an advanced Cosmeceutical, and it's all natural. I think it's important to point you in the direction of the amended cosmetic regulations on the use of retinol or the retinol initiative as it's called, which was introduced by the European Union. Jake, something has gone wrong with the slides. Can we go back to -- was introduced by the European Union on the 4th of April 2024. This basically reduces and enforces the reduction of retinol and cosmetics. In face care, the maximum it can be is 0.3% maximum retinol and in body care, 0.5%. Now, as of the 1st of November this year, no new products can be launched that exceed those limitations. And as of the 1st of May 2027, all existing formulations that are above those thresholds are to be removed from shelves. Now this is likely to be repeated worldwide, and it's all to do with the avoidance of overexposure to vitamin A, which causes significant long-term health problems, and that's exactly why this initiative has been brought in. The belief is that we receive enough vitamin A to our diet, and we don't need to overdo it with creams that contain retinol. Therefore, there is a race to find a natural replacement. This is it. So you can understand the excitement that surrounded this. That is a European Union initiative, not something that we created, or Croda. Jake, the slides seem to be glitching. Can I get on to -- Yes. So just in terms of the addressable market here, I thought it's important to point out just some of the products that are out there. This is all available on basically the website that's listed at the bottom there. Jake, it's still glitching. So 111 Skin rose mask, 18 million units sold. Aquaphor healing 45 million units sold. [indiscernible], there's 1 unit sold every 10 seconds. Next slide. AB Cream, one order every 90 seconds. BIOEFFECT, one every 5 seconds, Bobby Brown face base 1 every 9 seconds. And then Olive Olea, Procter & Gamble's jewel in the crown. There's over 60 million people use that product worldwide. So this is an enormous market, an absolutely enormous market. We have ourselves very squarely in the hands of Sederma and the Croda Beauty team. They developed Matrixyl. They built that up into hundreds of millions of revenue. We couldn't be in no better hands than this team of people to move this forward. I know there's a lot of questions about revenues thus far. We -- I can assure you, revenues have commenced. We will update our forecast as and when we can when we're allowed. We have an NDA in place that covers the launch and a little bit thereafter to give Croda Beauty and the Sederma team the opportunity to gauge reaction from the in-cosmetics show. You will have site numbers before our financial year-end, before the end of June, and we will also see revenues listed and reported before then. I cannot give you what I do not have. What we will say is this has been, as I showed in the time line, it's the end of a very long journey. It is a successful end to a journey. More importantly, this product is better than we could ever have imagined. It does everything we wanted and so much more. It is absolutely unique in its attributes and Croda have very, very high internal expectations. Moving on now to talk about Axis Biotix. In terms of Axis Biotix for psoriasis, you remember this product, it was launched in 2022 to alleviate symptoms of psoriasis. We sell this directly through Amazon and Royal products and also through our own website. Sales continue to lift, and we continue to see very high retention rates. Post year-end, we are in discussions with 2 U.K. high street retailer chains. One of those is significantly more advanced than the other. And as soon as I have news on that, we will be RNSing that. Obviously, I can't talk about before that. We also completed the efficacy and the launch of the trial of the product for acne. And that is part of the same commercial discussions that we are talking to the high street retail chains about. As you can see, we're refreshing our packaging to basically explore what this will look like on a shelf, and we're presenting them to the high street retail chains. Next slide, please, Jake. We're exploring multiple options, not just for psoriasis and acne, but as you can see for eczema and rosacea as well. This is part of a much wider campaign to get this product out there on an exclusive basis with one partner in the U.K. and then further overseas. And as I say, as soon as I have further news on that, we will report it. We are not resting on our laurels there. These large deals take time. PLCs and large retail chains do not move at the speed that small companies like ourselves move at, very frustrating, but I think we've proven with Croda and it was worth the wait in the end. In terms of our R&D program, the accelerated wound closure program continues with the Apgen project led by Professor Sheila [indiscernible] and Professor Andrew McBain. The aim of that project is to license this out to a multinational advanced wound care company. I've said this before, I can't stress it enough. This is extremely complex science. This is taking bacteria from a host gut and putting it into an open wound. So from a regulatory perspective, there are a lot of hurdles to overcome here in terms of compliance, in terms of consent. So we need to be very, very careful how we progress with this. It is moving along. I would like to think that we have a deal with a multinational [indiscernible] soon. I can't put a time line on that because it's beyond my control, but the science is moving along at a very nice pace indeed. The oral health program, we read out last year, the first phase of that. That program is now on a hold. We paused it, and that's because we require somewhere between GBP 300,000 and GBP 400,000 worth of additional input and additional cash to be spent in order to get that over the line and have an offering to put out to the likes of Colgate Palmolive or somebody of that [health]. We're not prepared to deploy that cash at this moment in time and won't do until funds from Croda are freely flowing and we have greater sight of what that pipeline looks like. In terms of inflammation, that program is headed by Professor Cath O'Neil, and that's fully funded. That program is ongoing and should see some kind of news on that towards the end of the year.
Manprit Randhawa
executiveThank you. In terms of the inorganic businesses, Dermatonics, our first acquisition in January 2024, a very quick integration completed shortly thereafter. For the half year end December '24, they reported revenues of GBP 0.3 million, so growth on the prior period, which was at GBP 0.9 million. EBITDA, GBP 0.27 million and growth on the GBP 0.3 million before. Our full year outturn for the year ended June 2025, we expect them to achieve revenue of GBP 2.9 million and estimated EBITDA of GBP 0.7 million. So the growth in revenue is pretty much across the board. We've seen increase in sales to the NHS in individual [indiscernible] clinics. We've seen expansion in Amazon in the U.K. and U.S. And then we've also seen the Modi partnership starting to move along as well nicely in its home country of India, where they are distributing to about 8,000 pharmacy outlets. We've also seen growth in the existing distributor relationships that Dermatonics has. And we've also seen new business wins in areas where they don't have relationships currently at the moment.
Stuart Ashman
executiveAnd I think it's important to say that we are still very, very confident indeed that we will hit that number. We are very much on track with that. And it is -- post acquisition, it is very much back-end loaded because of the points that Manprit raised.
Manprit Randhawa
executiveNext slide, please. Our second acquisition, Biotech Solutions, completed in October 2024. The reason we bought this business was its attractiveness, both from a manufacturing capability perspective, but also the synergies that we can implement with Dermatonics, where we started that process in Q1 2025. They achieved revenues of just over GBP 300,000, and this is for the period post acquisition from the middle of October '24 through the end of December '24 as well. That was growth on the prior year and the same with EBITDA. In terms of full year, on a full year pro forma basis, so had we had Biotech Solutions from the 1st of July 2024, they would outturn GBP 3 million of revenues and GBP 0.9 million of EBITDA. Again, we've had expansion within our existing customer base. And subsequently since the acquisition, some of their exposure, we've increased their marketing presence. They are starting to win more new business as a result. In terms of financial report, the numbers reported in March, total revenues of $1.58 million against $0.1 million in the prior period. Cost of sales have increased in line with revenue. Our gross profit margin has declined, and that's purely because of the mix of products we're selling now. So in HY '24, we only sold Axis by SPS, whereas today, we have the products sold by both Dermatonics and Biotech Solutions. I just illustrate there what their margins are at the moment. So 58% Dermatonics and 50% of Biotech Solutions. Our expectation is our gross margins will start to reach 60% as we implement further synergies across the next 6 to 12 months. In terms of the overhead base, that increased in HY '25. That's largely due to the impact of both the acquisitions, so increased headcount, office footprint, et cetera, et cetera. In terms of EBITDA and net losses, they decreased by 25%. And again, that's because of the accretive nature of both the acquisitions that we've made. Next slide. In terms of the balance sheet, we're comparing the 31st of December 2024 to the 30th of June 2024. So a couple of movements in the convertible loan that was cleared in July 2024, shortly after year-end. And then we took on GBP 960,000 of loans from a long-standing shareholder, and that supported the acquisition of Biotech Solutions. Post period end, that shareholder executed some warrants, which reduced the debt down to about GBP 600,000. In terms of the actual balance sheet itself, that was bolstered by the acquisition of Biotech Solutions. So in noncurrent assets and current assets, that's largely due to the impact of the Biotech Solutions acquisition. Next slide. I want to illustrate how our cash has moved since the 30th of June 2024. So we opened with GBP 800,000 worth of cash, net losses of just over GBP 1 million, a small working capital gain. As I mentioned, in August 2024, we completed the fundraise with Premier One of GBP 1.8 million. We took some loans from that long-standing shareholder of GBP 950,000. And then the acquisition of Biotech Solutions, just over GBP 1.4 million, resulting in a closing cash position of GBP 1.24 million at the end of December 2024. Next slide, please. So I presented this slide when we present the full year financial results, but I wanted to reiterate how we get to that GBP 6.3 million of pro forma revenues and past breakeven on an EBITDA basis. So, you can see the [indiscernible] of revenues from SkinBio [indiscernible] products only. There's no product revenues in this whatsoever. We've got GBP 2.9 million of Dermatonics, and then we've got GBP 3 million of BTS revenues. So when I say pro forma, I mean had we had both Dermatonics and BTS on the 1st of July 2024, and we executed synergies of $600,000, we would have achieved $6.3 million of full year revenues and GBP 0.4 million of positive EBITDA.
Stuart Ashman
executiveSo in summary, the Croda Global launch is now complete. I know it was a long wait. Zenakine has now hit the world stage. We've had a lot of criticism about how long this has taken. I've said this before, the pathway of complex science is never linear. I've said it a dozen times, and it's not. And I think that time line showed that. This was well worth the wait. Sederma are incredibly excited about this. And I think do we trust Sederma? They are our commercial partner here. Yes, they have executed the launch of some of the biggest cosmetic ingredients in the world. The buzz on the stand was palatable. You name it, it was a who's who of cosmetic giants that were on that stand and the buzz were on and everyone's with Zenakine. We do have access to forecast post launch. Once I have them, you will have them. In terms of recognition of revenue, that's a very complex process. The sales pipeline is open. Croda have made sales. And as soon as we are able to report them, we will. That's not going to be a long wait. We are working with our analysts to upgrade that report. But as soon as we can do that, we will. In terms of AxisBiotix, the national Psoriasis Foundation Accreditation was applied for. We've been notified that we have that now. We're just waiting for the paperwork to come through. That will allow us to put that Rosetta of excellence as the first food supplement for psoriasis approved by the biggest psoriasis charitable organization in the world. We'll be able to put that on our packaging when we launch with a high street retail chain. I'm hoping to have news on that very shortly as soon as I do. Obviously, I'm duly bound and legally bound to release that as an RNS, and I will absolutely do that. Why would I not? It would be my pleasure to do so. In terms of R&D projects, the inflammation project with Professor Cath O'Neil continues. The oral program with Professor Andrew McBain is on pause until we've got sufficient cash to throw at that. And the Epiderm project with Professor [indiscernible] is on track and running very, very well. Indeed, that feeds into the MediBiotix project. And then in terms of AxisBiotix having done psoriasis and acne, we're now looking at eczema and rosacea. In terms of mergers and acquisitions, as Manprit's just said, given great detail on those businesses are now integrated. Biotech Solutions are now manufacturing many of the products that Dermatonics were previously buying in from a third party. The upside of that is circa GBP 600,000 when it's fully integrated, and that's GBP 600,000 that stays within the group. In terms of further acquisitions, I've said this before, let me put the silly bullet and board rumors to bed. We are not rushing out and buying companies tomorrow. We're not buying anything this side of the summer. In fact, I'm not sure we'll buy anything at all this year. We reserve the right to continue the search for positive acquisitions that may well bolster the group's fortunes and create great stability, but we're not rushing out to fundraise in order to do that. We need to see a clear visibility of the Croda pipeline and the forecast therein before we move on that. So let's just put that to bed once and for all. In terms of financial outlook, as Manprit has clearly pointed out, combined pro forma turnover on an annualized basis of GBP 6.3 million. EBITDA puts us beyond breakeven. And again, let me put this one to bed. We have 0 cash concerns whatsoever. We are not running out of cash, and we are not going to be dashing out to do a fundraise to proper working capital for this company, simply not needed. Next slide, please. This picture has been put up in 2019. It was our strategic vision for the company. We started off with the pillars and the Pantheon as we called it. The skin Biotix pillar is well and truly now achieved. The Croda launch has taken place. We have a product called Zenakine. It is out there now being sold by a small army of people worldwide to the biggest cosmetic companies and the smallest cosmetic companies in the world. It is all natural. It is a natural replacement for [indiscernible] and many, many other products out there. We also -- we can well and truly say we've ticked that box. You could also argue that within that pillar, some of the Dermatonics products sit where we sell cosmetic foot creams, et cetera, et cetera and [30-foot forms]. The AxisBiotix pillar, we've been selling that since 2022. We continue to increase sales. We continue to retain the retention levels, the great retention levels that we've had, they continue very high, very high 80s, early 90% in terms of people who come back and buy us again and again. We are very close to an agreement with a U.K. high street retail chain. And again, when I have news on that, of course, I will RNS immediately. You've seen the preparation, the various packaging designs we've done. This is for retail. It's not the sort of stuff that we get. Our subscribers currently get talking to their letter box. So we ticked that box too, and we will continue to evolve with Eczema and with rosacea there. Medibiotix is ongoing. The project with Professor [indiscernible] in Project Epiderm leads towards an advanced wound care product. We are still in discussions with a very highly regulated, very complex area. The other 2 pillars are very much fuel for the future. But I think we've underpinned that Pantheon with solid foundations. AxisBiotix was our first revenue-generating product that went out there. We acquired Dermatonics after that in January of 2024, that's going from strength to strength. Biotech Solutions is another excellent acquisition, now manufacturing Dermatonics products amongst so many other products. And now finally, I'm delighted and very proud to announce that we underpin the financial security of the company with Zenakine. As soon as I have any news whatsoever on that, I will absolutely RNS that.
Operator
operatorPerfect. Stuart, Manprit. If I may just jump back in there. Thank you very much indeed for your presentation this morning. [operator instructions] I just like to remind you that a recording of this presentation, along with a copy of the slides and the published Q&A can be accessed via your investor dashboards. Guys, it seems like we have received a number of questions that were both pre-submitted ahead of today's event as well as those that have come in throughout your presentation this morning as well. So firstly, thank you to all of those on the call for taking the time to submit their questions. Stuart, obviously, given the significant attendance on today's call, you may not be able to get through all of the questions, but of course, we'll give these back to you afterwards for you to review. But at this point, guys, if I may just hand back to you just to read out those questions and give your responses where it's appropriate to do so. And if I pick up from you at the end, that would be great.
Stuart Ashman
executiveThank you. Yes, there's nearly 100 questions here. So we'll do our -- a lot of them are repetitive, but we'll do our best to get through them. So the first one, having been repeatedly told that what attractive product skin biotix was the first ingredient to tackle the whole trinity of skin barrier function by reducing [indiscernible], transdermal water loss, closing of tight junctions and improving elasticity, why was the focus of the launch purely on new findings related to more rested appearance with fuel? Look, I think we answered that in the fireside chat with Dr. Surinder Chahal -- this was launched at a cosmetic ingredient show. So it is a given that you are launching a cosmetic ingredient and not something that sends you to sleep. It's because of those additional attributes that this product is in a category of its own, is a new primary color is another phrase that was used. This absolutely does in the slides which we will upload that deck, not only will we upload this IMC presentation to our website, we'll also -- [indiscernible] think we can do that upload the Croda technical deck to the website so that people can have a look at that. There's some incredible statistics in there that address exactly what you're talking about, the transdermal water loss, closing of tight junctions, increased skin elasticity, restoration of elasticity and they improve barrier function and they're statistically listed in that slide deck. So it is all of the things that we said it was going to be and Croda were looking for, and it's so much more. The next question is, why is the SkinBiotix patented name not retained within the Zenakine's product category? Okay. That's quite a simple one to answer. When you launch a product on a global basis, you have to run through a global search on what is translatable across worldwide platforms in every language. SkinBiotix is not translatable across every language. This was a strategic name for a pillar that ultimately became the name of a project. That project was the project that we did with Croda and with Sederma. Zenakine is a multilingual translatable name. So that is the name they have run with. Our names are all of the IP and the patents. Frankly, in terms of our marketing, we can directly point to Zenakine. It is our IP. So we just have to point people in the right direction. How likely is it that Croda will announce new ingredients based on our lysate and how soon could that happen? The bloodhounds on the boards found on the very same day that was launched, a list of 6 formulations where it's already combined with existing products that are out there. When we pointed that out to Croda and said that there's a leak of 6 formulations out there, they lapped and said more like 600. So it's already being partnered. It isn't -- remember, this is not a finished product. It's an ingredient. It's already being partnered with multiple other cosmetic ingredients that give color, et cetera, et cetera, to form final products and finished products. But this does the job that 4 or 5 other ingredients would we do, would have to be combined to do. So yes, you will see some new formulations and new ingredients come up. And there is an entire media rollout of this by Croda and Sederma that will take place now that the launch is complete. How likely is it that Croda will announce -- we've already done that one. I realize the company has no control over when products are launched. Can you give investors some indication of when we might see Zenakine on the shelves? Well, the short answer to that is we don't sell Zenakine, Croda and Croda Beauty do. I would imagine it, you won't have to wait very long. Some of the VIPs have been working with this for some time. Please understand that when the VIPs acquire this ingredient and formulate it, they have to do aging studies, et cetera, et cetera. So they're not just going to launch, let's, for example, say, Olive Ole with now containing Zenakine day 1, week 1. They've obviously have to do stability testing. What does it look like after 6 months? Does it turn the product around? Does it impact viscosity? Does it impact odor, et cetera, et cetera. But what I can say is that those tests have been going on for quite some time. So I don't think you've got particularly long to wait. What is the time duration of the NDA with Croda? Okay. The NDA forms part of the actual commercial agreement. It is very specific to the launch and the period post launch, which gives them the coverage of a few months so that they can gauge market reaction to the launch in Amsterdam. We agreed to that given the bay of secrecy that was put over this. As Dr. Surinder Chahal pointed out, this has never been done before. There's nothing else like this on the market that can claim to restore sleep, improve circadian rhythm. The skin matrix regeneration that he talked about that's detailed in their slide is second to none. There's nothing that comes anything close to this product. So I would imagine there's a bit of a race now to get this product out there. Croda are eager to gauge that market reaction. As soon as I get a green light, and I would imagine it will be in the next month or 2, we will release whatever information we are able to release. Part of their contract does give us quarterly forecast, we are paid quarterly in arrears. So once that [indiscernible] lifts, we will literally lift the curtain and reveal everything that we've got. Zeneca is part of several formulations containing other ingredients. Do we get our double-digit royalty on the percentage of sales of the full formulation? Or do we get a percentage of a percentage? If the latter did you negotiate the split of revenues formulation by formulation or were you told it by Croda. Let's be clear on this, we get double-digit royalties on the sale of Zenakine as an ingredient. If that's put in with other ingredients by Estée Lauder, Procter & Gamble, et cetera, we don't get percentages of somebody else's ingredient that would be unreasonable to expect that. The Acne Access Biotix launch was possibly due before Christmas, but early 2025. We're now nearing the end of April. What on earth is the delay. As I said, large launches take a while to negotiate. We are very advanced indeed in negotiations. As I've said earlier, you've seen the mockups of retail-ready packaging, not just for psoriasis and acne, but also for rosacea and eczema and that's how advanced those negotiations are. We're putting together markups of packaging for a family of products that we haven't even formulated yet. That's the interest that we have from these people. I can't give a date because I would have to RNS that. But when I say we're very close, we're very close indeed, and that would be on an exclusive basis. When will the broker note be updated with revenues from Croda? We are working with our broker. Obviously, we are bound by certain elements of the NDA. We're not breaching any PLC rules. We're not breaching any revenue recognition rules. We are well within the boundaries of the NDA. We're well within our operating guidelines. What I will say, as I've said earlier, is revenues have begun. That's all I can say. Outside of that, as soon as I have notification and clearance, we will update the analyst statement. So yes, that's as much as I can say on that, but revenues have begun. [Zenakine] seems to enhance various things, sleep and the aging, are we likely to see customers selling a range of different products, which could all include Zenakine? Yes, indeed, that is very much the whole. I put up some examples of some of the products that are out there that contain retinol because there are hundreds of thousands of products out there that contain retinol. There are hundreds of thousands out there that don't. There are -- I mean, what I will say is at the show, I was very surprised to see people from their own hotel chains, very large ones, representatives of international hotel chains, representatives of companies that manufacture mattresses and pillows that were looking for sleep aids and looking for fragrances that they can put in the hotel rooms and things to help people sleep. So I mean the market is way, way bigger than we had initially thought, but it covers multiple, multiple products. It's not -- this is not just a night green. The stock that [indiscernible] pointed out, it rejuvenates your skin during the day, during the night and restores your sleep lower stress levels, and we've clinically proven that during very extensive trials. And then furthermore, it protects your skin and rejuvenates it during the day. So there's multiple applications for this product. How does Zenakine fit with Croda and Sederma's existing product portfolio? Is SkinBiotix the only microbiome 100% natural product that is marketed as an all-in-one product that can address stress, aging and well-being? Yes, it is. It's created its own category. As the technical lady said, it's a new primary color. It's when customers come to Sederma and say, I'd like to create a fragrance, I'd like to create a product, a cream, I'd like to create a serum. This is what I wanted to do. This product Zenakine ticks multiple boxes. So rather than using 5 or 6 products, they can use 1 to do it all. So it is literally, as it was described, again, a Swiss Army life. Jake, have i got time for more?
Operator
operatorWe are just coming up over the hour now. So what we can do is we can give you back all of the questions immediately after the presentation has ended for you to review, and then we can publish those responses out on the platform for the attendees to access if that works. Perfect. Well, Stuart, Manprit, thank you very much indeed. And Stuart, perhaps before really just looking now just to redirect those on the call to provide you their feedback, which I know is particularly important to yourself and the company. If I could please just ask you for a few closing comments just to wrap up with, that would be great.
Stuart Ashman
executiveThank you. So thank you all for taking the time to listen. My apologies if that went over the hour. We normally try to get this wrapped up within 60 minutes. And the bulk of that was taken up with Dr. Surinder Chahal's lengthy technical presentation. We felt quite deeply that you've had the right to see the entire technical presentation and have someone that's been intricately involved in this project explain just how extraordinary this product truly is. It has been a lengthy and tedious journey. It's been fraught with pitfalls and go, no-go hurdles, but we are past that now. The product is now launched -- what happens now is in the hands of Sederma. We could not have picked a better partner. I know a lot of people feel that Croda have been too guarded and too secretive with their information. I am assured that, that will lift now that this is launched and once they gauged activity in market. Can I also stress that the acquired entities are going from strength to strength. I'd also like to say that we do not intend to be doing acquisitions anytime soon and burning cash. And on the cash front, as Manprit has pointed out tirelessly throughout the presentation, as I have, we have no cash concerns whatsoever. We have enough cash without anything at all from Croda to last through till the summer of 2026. This company has moved from research and development into truly operational and revenue generating and very quickly, we will move into profitability and cash generating. I'm very proud of what this team have delivered. I know it's been frustrating and as investors. I hope that the destination will be well worth the journey. Thank you for your time.
Operator
operatorPerfect. Stuart, Manprit. thank you once again for updating investors today. Could I please ask investors not to close this session as you will now be automatically redirected for the opportunity to provide your feedback in order the management team can better understand your views and expectations. This will only take a few moments to complete, but I'm sure it will be greatly valued by the company. On behalf of the management team of Skin Biotherapeutics plc, we would like to thank you for attending today's presentation. That now concludes today's session. So good afternoon to you all.
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